Lisodim (50mg) 20 Tablets

Diclofenac Sodium 50mg Tablet primarily exerts its analgesic, anti-inflammatory, and antipyretic effects through inhibition of cyclooxygenase (COX) enzymes, particularly COX-2. By blocking these enzymes, diclofenac interferes with the production of prostaglandins, which are key mediators in the inflammatory process. This mechanism leads to reduced inflammation, pain relief, and decreased fever. Specifically, diclofenac inhibits the conversion of arachidonic acid to prostaglandin H2, a precursor of various prostaglandins and thromboxanes, thus suppressing the inflammatory response in the body. This action underlies the therapeutic benefits of diclofenac in managing pain, inflammation, and fever associated with various conditions.

Diclofenac Sodium 50mg

Non-steroidal anti-inflammatory drug (NSAID)

Tablet

The following are the uses of Diclofenac Sodium 50mg Tablet:

• Used for relieving acute pain, such as post-surgical pain or pain from injuries.
• Used for reducing inflammation and managing pain in conditions like arthritis.
• Used for treating migraine headaches to alleviate pain and reduce frequency.
• Used for managing pain and inflammation in cases of gout.
• Used for providing relief in menstrual cramps and associated pain.
• Used for reducing fever and managing pain in cases of flu or other infections.
• Used for controlling pain and swelling after dental procedures.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For pain relief from moderate to severe osteoarthritis of the knee- 100 mg to 150 mg, taken as a single dose or divided into 2 doses (1 tablet of 100 mg 3 times per day).
• For pain relief from rheumatoid arthritis- 100 mg to 150 mg taken once a day or divided into 2 doses (1 tablet of 100 mg 3 times per day).
• For analgesia after dental surgery- 1.8 mg/kg (maximum 150 mg) taken once either before or after surgery.
• For analgesia after general surgery- 2 mg/kg (maximum 200 mg) taken once either before or after surgery.
• For non-specific muscle pain and spasms- 50 mg to 100 mg taken once or twice a day.
• For migraine pain- Initially, 50 mg to 100 mg taken once, and then 25 mg to 50 mg every four hours as needed.
• Maximum dose in a day for oral formulations should not exceed 200 mg

In the case of an overdose of Diclofenac Sodium 50mg Tablets, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and in severe cases, gastrointestinal bleeding. Immediate medical attention is necessary to manage these symptoms effectively. Treatment may involve gastric decontamination procedures, such as stomach pumping or administering activated charcoal to prevent further absorption of the drug. It is crucial to seek professional medical help promptly to ensure appropriate management and minimize potential complications.

In the case of a missed dose of Diclofenac Sodium 50mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss several doses, contact your healthcare provider for advice on how to proceed, as they may recommend adjusting your dosing schedule to ensure the medication remains effective.

To take Diclofenac Sodium 50mg Tablet, swallow the tablet whole with a glass of water, preferably with or after food, exactly as prescribed by your doctor, usually 2 to 3 times a day, or follow the instructions provided on the medication guide.

Here are the conditions and situations when Diclofenac Sodium 50mg Tablet should not be taken:

• Do not use if you have a known allergy or hypersensitivity to Diclofenac, aspirin, or other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).
• Avoid using Diclofenac if you have a history of asthma attacks, hives, or other allergic reactions triggered by NSAIDs.
• Contraindicated in individuals with active or recent gastrointestinal bleeding or perforation.
• Should not be used in patients with severe heart failure or heart disease.
• Not recommended for individuals with active peptic ulcer or a history of recurrent peptic ulcers.
• Avoid using it if you have severe kidney or liver disease.
• Diclofenac is not suitable for patients with bleeding disorders or those on blood-thinning medications.
• Do not take this medication if you have recently undergone coronary artery bypass graft (CABG) surgery.
• Contraindicated in individuals with certain metabolic disorders, such as porphyria.
• Should not be used during the last trimester of pregnancy due to potential fetal risks.

The side effects of Diclofenac Sodium 50mg Tablet may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Constipation
• Dizziness or vertigo
• Skin rash or itching
• Increased blood pressure
• Headache

Following are the precautions and warnings for Diclofenac Sodium 50mg Tablet:

• Not recommended for individuals with a history of allergic reactions to NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) or aspirin.
• Patients with gastrointestinal issues like bleeding, ulcers, or inflammatory bowel disease should exercise caution and consult a doctor before use.
• This medication may increase the risk of cardiovascular events such as heart attack or stroke, especially with long-term use. Regular monitoring is advised.
• Not suitable for patients with severe heart failure or established cardiovascular disease.
• Kidney function should be monitored regularly, particularly in elderly patients and those with existing kidney problems.
• May cause liver damage; individuals with liver disease should use with caution and undergo regular liver function tests.
• Not recommended during pregnancy, especially in the third trimester, due to potential harm to the fetus. Consult a doctor for alternative options.

Following are the drug interactions for Diclofenac Sodium 50mg Tablet:

• Aspirin or other NSAIDs (e.g., ibuprofen, naproxen) can increase the risk of gastrointestinal bleeding and ulcers.
• Lithium or diuretics may have reduced elimination, leading to potential toxicity.
• Warfarin or other anticoagulants can have enhanced effects, increasing bleeding risk.
• ACE inhibitors or angiotensin receptor blockers (ARBs) may lead to decreased antihypertensive effect.
• Methotrexate levels can be increased, potentially leading to more adverse effects.
• Cyclosporine may have increased blood concentration, requiring close monitoring.
• Antidiabetic drugs may need adjustment due to altered glycemic control.

Following are the food interactions for Diclofenac Sodium 50mg Tablet:

• Avoid excessive alcohol consumption as it may increase the risk of stomach bleeding and liver damage.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Diclofenac, potentially increasing its levels in the blood and the risk of side effects.
• Limit the intake of foods high in potassium, such as bananas, oranges, and tomatoes, as Diclofenac can increase potassium levels in the body.
• Avoid high-sodium foods as Diclofenac can cause sodium retention, leading to increased blood pressure.
• Caffeine-rich beverages like coffee and energy drinks may enhance the absorption of Diclofenac, potentially increasing its effects and side effects.
• Consuming Diclofenac with fatty meals may delay its absorption, leading to a slower onset of action.
• Avoid foods that may irritate the stomach, such as spicy dishes, as Diclofenac can increase the risk of gastrointestinal issues.
• Always follow healthcare advice regarding dietary restrictions and adjustments while taking Diclofenac.

Diclofenac Sodium 50mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature (between 20-25°C) and away from excessive heat, moisture, or direct sunlight. It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to environmental factors. Do not store them in the bathroom or kitchen, as these areas may have temperature fluctuations. Regularly check the expiration date, and dispose of any expired tablets promptly. When disposing of unused or expired medication, do not throw them in the trash or flush them down the toilet. Contact your pharmacist or local waste management authority for guidance on proper disposal methods to ensure environmental safety. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Diclofenac Sodium 50mg Tablet:

• Consult a doctor for prescription and guidance before taking this medication.
• Take the tablet with a full glass of water as directed by your healthcare provider.
• Ensure you swallow the tablet whole without crushing or chewing for optimal effect.
• Diclofenac is best taken with food to prevent stomach upset.
• Avoid alcohol consumption as it may increase the risk of stomach bleeding.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the tablets at room temperature, away from moisture and heat.
• Do not share this medication with others, even if their symptoms are similar.

Diclofenac sodium is a standout pain-relieving medication and reducer of inflammation and fever, frequently used to treat rheumatoid arthritis, osteoarthritis, and other joint pain. This medication should be used with caution and under a doctor's supervision, although it is not a prescription drug. Depending on the individual's needs, various lab tests may be required, particularly if they have underlying medical conditions that require close monitoring. Discussing other necessary lab tests with your doctor is recommended if you have specific medical conditions or are taking other medications. Your doctor may recommend regular blood tests to monitor your blood cells, liver and kidney function, and other essential markers. This is done to identify any signs of anemia or thrombocytopenia resulting from long-term use. Regular liver and kidney function tests are necessary to ensure the medication is not causing any undue stress on these organs. Periodic blood pressure checks with your doctor may also be recommended, given diclofenac sodium's effect on blood pressure and the potential for issues with kidney function. Additionally, electrolyte panels may be monitored to ensure potassium levels are within the normal range, helping identify any issues with kidney function and assisting in managing the side effects of the medication. Conducting these lab tests periodically or as needed, under the guidance of your healthcare provider, is essential to ensure diclofenac sodium's safety and efficacy, considering your individual circumstances.