Lodopin-V HCT (10mg+160mg+12.5mg)

The combination of Amlodipine, Hydrochlorothiazide, and Valsartan in this tablet works synergistically to lower blood pressure through multiple mechanisms. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into smooth muscle cells, leading to vasodilation and reduced peripheral resistance. Hydrochlorothiazide, a diuretic, promotes the excretion of sodium and water, decreasing blood volume and reducing blood pressure. Valsartan, an angiotensin II receptor blocker, blocks the binding of angiotensin II to its receptors, preventing vasoconstriction, and reducing blood pressure by inhibiting the renin-angiotensin-aldosterone system. Together, these mechanisms contribute to the effective management of hypertension by relaxing blood vessels, reducing fluid retention, and modulating the body's hormonal response to maintain optimal blood pressure levels.

Amlodipine 10mg, Hydrochlorothiazide 12.5mg, valsartan 160mg

Calcium channel blocker, Diuretic, Angiotensin II antagonist.

Tablet

The following are the uses of Amlodipine 10mg, Hydrochlorothiazide 12.5mg, valsartan 160mg Tablet:

• Used for treating high blood pressure
• Used to relax and widen blood vessels, reducing hypertension
• Used to lower blood pressure by increasing urination and fluid loss
• Used to block the actions of certain hormones to relax blood vessels
• Used for managing chest pain and reducing the risk of heart attack
• Used to prevent further damage to the heart and blood vessels
• Used to improve blood flow and oxygen supply to the heart
• Used to manage and prevent complications related to hypertension

In the case of an overdose of Amlodipine 10mg, Hydrochlorothiazide 12.5mg, and Valsartan 160mg tablets, it is important to recognize the potential severity of this situation. Overdosing on these medications may lead to symptoms such as dizziness, lightheadedness, and an irregular heartbeat. In such cases, prompt medical attention is necessary. It is crucial to seek emergency care, where healthcare professionals can provide appropriate treatment and support to manage any adverse effects and ensure the patient's well-being.

In the case of a missed dose of Amlodipine 10mg, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. For Hydrochlorothiazide 12.5mg, if you miss a dose, take it as soon as you notice, unless it's close to the time for your next dose. Then, simply take the next dose as scheduled. If you miss a dose of valsartan 160mg, take it as soon as possible, but if it's near the time for your next dose, skip the missed dose and resume your regular dosing schedule. It's important to consult your healthcare provider if you frequently miss doses or have concerns about managing your medication routine.

To take the Amlodipine 10mg, Hydrochlorothiazide 12.5mg, and Valsartan 160mg tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider.

Following are the conditions/situations when Amlodipine 10mg, Hydrochlorothiazide 12.5mg, and Valsartan 160mg Tablet should not be used:

• Should not be used if you are allergic to any of the active ingredients, Amlodipine, Hydrochlorothiazide, or Valsartan, or any other related calcium channel blockers, thiazide diuretics, or angiotensin II receptor blockers.
• Contraindicated in patients with severe liver disease or biliary obstruction.
• Should not be used in individuals with a history of angioedema caused by previous ACE inhibitor or ARB therapy.
• Not suitable for patients with severe renal impairment or active liver disease.
• Should not be used during pregnancy or while breastfeeding.
• Contraindicated in patients with severe hypotension (very low blood pressure).
• Not recommended for individuals with aortic stenosis or obstructive hypertrophic cardiomyopathy.
• Should not be used in patients with hypercalcemia (high calcium levels in the blood).

The side effects of Amlodipine 10mg, Hydrochlorothiazide 12.5mg, and Valsartan 160mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Nausea and vomiting
• Diarrhea or constipation
• Skin rash or itching
• Swelling in the legs or ankles
• Increased sensitivity to sunlight

Following are the precautions and warnings for Amlodipine 10mg, Hydrochlorothiazide 12.5mg, and Valsartan 160mg Tablet:

• This medication should not be used in patients with known allergies to any of its components, including amlodipine, hydrochlorothiazide, or valsartan.
• Patients with a history of liver or kidney problems should use this medication with caution, as it may require dosage adjustments.
• It is important to monitor blood pressure regularly while taking this medication, especially during the initial treatment period.
• Avoid excessive potassium supplements or salt substitutes containing potassium without medical advice, as this medication can affect potassium levels.
• Caution is advised for patients with a history of heart disease, as it may affect heart function.
• This medication may cause dizziness; patients should avoid driving or operating heavy machinery until they know how this medication affects them.
• Pregnant or breastfeeding women should consult their doctor before taking this medication, as it may have potential risks to the fetus or infant.
• Inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Amlodipine 10mg, Hydrochlorothiazide 12.5mg, and Valsartan 160mg Tablet:

• Amlodipine may interact with CYP3A4 inhibitors (e.g., ketoconazole, grapefruit juice) increasing its blood levels, potentially leading to enhanced side effects.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the antihypertensive effects of Amlodipine and Hydrochlorothiazide.
• Hydrochlorothiazide may decrease the elimination of lithium, increasing the risk of lithium toxicity.
• Valsartan's effectiveness may be reduced by NSAIDs, especially in patients with depleted intravascular volume.
• Potassium-sparing diuretics (e.g., spironolactone) or potassium supplements can increase the risk of hyperkalemia when used with Valsartan.
• Hydrochlorothiazide can increase blood glucose levels, and the dosage of antidiabetic medications may need adjustment.
• The combination of Hydrochlorothiazide and Valsartan with other blood pressure-lowering medications may require careful monitoring due to potential additive effects.
• Drugs affecting renal function, such as NSAIDs or cyclosporine, may impact the effectiveness of Hydrochlorothiazide and Valsartan.

Following are the food interactions for Amlodipine 10mg, Hydrochlorothiazide 12.5mg, and Valsartan 160mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they can decrease the breakdown of Amlodipine, Hydrochlorothiazide, and Valsartan, leading to increased levels of these medications in the body and potentially causing side effects.
• Alcohol may increase the risk of dizziness and lightheadedness, especially with Amlodipine and Valsartan, as they can lower blood pressure.
• Avoid excessive salt (sodium) and potassium-rich foods while taking Hydrochlorothiazide, as it is a diuretic and can affect electrolyte balance.
• Limit or avoid licorice consumption as it may reduce the effectiveness of Valsartan.
• Maintain a consistent potassium intake; Hydrochlorothiazide can reduce potassium levels.
• Avoid or limit high-fat meals with Valsartan to ensure consistent absorption.
• Follow a healthy diet as recommended by your doctor to manage blood pressure effectively.
• Always consult your healthcare provider for personalized dietary advice.

Amlodipine 10mg, Hydrochlorothiazide 12.5mg, and Valsartan 160mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to keep the medication away from heat sources and not store it in the bathroom due to temperature and humidity concerns. Always check the expiration date, and if the medication has expired or is no longer needed, proper disposal is essential. Do not dispose of it in wastewater or household waste; consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Amlodipine 10mg, Hydrochlorothiazide 12.5mg, and Valsartan 160mg Tablet:

• Consult your doctor for the correct dosage and administration instructions.
• Take the tablet as directed, typically once daily, at the same time each day.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• You can take this medication with or without food, but be consistent with your choice.
• Maintain a consistent medication schedule to ensure effective blood pressure control.
• Do not stop taking the medication without consulting your doctor to prevent potential complications.
• Inform your doctor about all the medications you are taking to avoid potential drug interactions.