Lodopin-V HCT (5mg+160mg+12.5mg)

The combination of Hydrochlorothiazide 12.5mg, Amlodipine 5mg, and Valsartan 160mg in a single tablet works synergistically to lower blood pressure through multiple mechanisms. Hydrochlorothiazide acts as a diuretic, promoting the increased excretion of sodium and water, which reduces blood volume and subsequently lowers blood pressure. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into smooth muscle cells, leading to vasodilation and reduced peripheral resistance. Valsartan, an angiotensin II receptor blocker, blocks the binding of angiotensin II to its receptors, resulting in relaxation of blood vessels and decreased blood pressure by inhibiting the vasoconstrictive and aldosterone-secreting effects of angiotensin II. Together, these mechanisms contribute to the effective management of hypertension by reducing blood pressure and improving cardiovascular outcomes.

Hydrochlorothiazide 12.5mg, Amlodipine 5mg, valsartan 160mg

Angiotensin II Receptor Blocker, Calcium Channel Blocker, Diuretic

Tablet

The following are the uses of Hydrochlorothiazide 12.5mg, Amlodipine 5mg, valsartan 160mg Tablet:

• Used for treating high blood pressure (hypertension) to lower the risk of stroke, heart attack, and kidney problems.
• Used to reduce fluid buildup (edema) in conditions like heart failure.
• Used to improve blood flow and relax blood vessels, easing the heart's workload.
• Used for managing hypertension when other medications are not providing sufficient control.
• Used to improve blood circulation and prevent complications related to high blood pressure.
• Used to help the body eliminate excess fluid, reducing strain on the heart.
• Used for long-term management of hypertension and related cardiovascular risks.

In the case of an overdose of Hydrochlorothiazide 12.5mg, Amlodipine 5mg, and Valsartan 160mg tablets, individuals may experience symptoms such as excessive urination, dizziness, and a rapid or irregular heartbeat. Prompt medical attention is necessary, as this combination of medications can lead to severe hypotension, electrolyte imbalances, and potentially life-threatening cardiovascular complications. It is crucial to seek emergency care and provide healthcare professionals with information about the ingested medications.

In the case of a missed dose of Hydrochlorothiazide 12.5mg, take it as soon as you remember, but skip it if it's almost time for your next dose. For Amlodipine 5mg, take the missed dose as soon as possible, unless it's nearly time for your next scheduled dose, then continue with your regular dosing schedule. If you miss a dose of valsartan 160mg, take it as soon as you remember, but if it's close to your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

To take the Hydrochlorothiazide 12.5mg, Amlodipine 5mg, and valsartan 160mg tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider.

Here are the conditions and situations when Hydrochlorothiazide 12.5mg, Amlodipine 5mg, and Valsartan 160mg Tablet should not be used:

• Should not be used in individuals with a known allergy to any of the components, including Hydrochlorothiazide, Amlodipine, or Valsartan.
• Contraindicated in patients with a history of angioedema caused by previous use of Amlodipine or other similar medications.
• Not recommended for individuals with severe renal impairment or patients on dialysis.
• Should not be used in patients with severe liver disease or biliary obstruction.
• Contraindicated during pregnancy, especially in the second and third trimesters, as it may cause harm to the fetus.
• Not suitable for individuals with low blood pressure (hypotension) or those who are experiencing frequent or severe dizziness.
• Should be avoided in patients with a history of heart or blood vessel disease, such as aortic stenosis or obstructive hypertrophic cardiomyopathy.
• Not recommended for individuals with gout or a history of elevated uric acid levels.
• Should not be used in patients with a history of systemic lupus erythematosus, as it may worsen the condition.
• Contraindicated in individuals with diabetes who are taking aliskiren.
• Not suitable for patients with significant electrolyte imbalances that have not been corrected.

The side effects of Hydrochlorothiazide 12.5mg, Amlodipine 5mg, and Valsartan 160mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Nausea or stomach pain
• Increased sensitivity to sunlight
• Skin rash or itching
• Swelling in the legs, ankles, or feet
• Low blood pressure (hypotension)

Following are the precautions and warnings for Hydrochlorothiazide 12.5mg, Amlodipine 5mg, and Valsartan 160mg Tablet:

• Patients with a known allergy to any of the components, including Hydrochlorothiazide, Amlodipine, or Valsartan, should not take this medication.
• Blood pressure should be monitored regularly, especially in the initial stages of treatment, as it may cause hypotension.
• Kidney function should be assessed before and during treatment, as it can affect renal function.
• Electrolyte levels, particularly potassium and sodium, should be monitored as this medication can cause imbalances.
• Caution is advised for patients with liver disease, as it may worsen liver function.
• Diabetic patients should be cautious as it can alter blood sugar levels.
• This medication may cause dizziness; patients should avoid activities requiring alertness until they know how it affects them.
• Pregnant and breastfeeding women should consult their doctor, as the risks and benefits should be carefully evaluated.

Following are the drug interactions for Hydrochlorothiazide 12.5mg, Amlodipine 5mg, and Valsartan 160mg Tablet:

• Lithium levels can be increased, leading to potential lithium toxicity.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may decrease the blood pressure-lowering effect of these medications.
• The risk of angioedema may be increased when combined with angiotensin-converting enzyme inhibitors (ACE inhibitors).
• Hypokalemia can be worsened when used with other potassium-depleting drugs.
• The antihypertensive effect may be reduced when taken with non-potassium-sparing diuretics.
• Amlodipine levels can be affected by CYP3A4 inducers and inhibitors, potentially requiring dosage adjustments.
• Valsartan may increase the risk of hyperkalemia when used with potassium-sparing diuretics or potassium supplements.

Following are the food interactions for Hydrochlorothiazide 12.5mg, Amlodipine 5mg, and Valsartan 160mg Tablet:

• Avoid excessive salt (sodium) intake, as Hydrochlorothiazide is a diuretic and high sodium foods can counteract its effect.
• Limit grapefruit and grapefruit juice consumption as they can affect the metabolism of Amlodipine, potentially increasing its levels in the blood.
• Alcohol may interact with Amlodipine, leading to increased side effects like dizziness and lightheadedness.
• Valsartan may interact with high-potassium foods like bananas, oranges, and green leafy vegetables, so monitor potassium levels.
• Avoid licorice, as it can reduce the effectiveness of Valsartan and increase blood pressure.
• Do not consume potassium supplements without medical advice, as Hydrochlorothiazide can cause potassium loss.
• Follow a balanced diet as directed by your healthcare provider to manage blood pressure effectively.

Hydrochlorothiazide 12.5mg, Amlodipine 5mg, and Valsartan 160mg tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity. Avoid exposure to high temperatures or humidity, and never store it in the bathroom or near heat-emitting appliances. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult your pharmacist for safe disposal practices, and always keep medicines out of children's reach to prevent accidental consumption. Proper storage and disposal are crucial for maintaining the efficacy and safety of these medications.

Following are the quick tips for Hydrochlorothiazide 12.5mg, Amlodipine 5mg, and Valsartan 160mg Tablet:

• Adhere to the dosage instructions provided by your doctor for the best therapeutic outcome.
• Maintain a consistent schedule for taking your medication, preferably at the same time daily.
• Ensure you swallow the tablet with a full glass of water for better absorption.
• Avoid consuming tea, coffee, or dairy products immediately after taking the medication.
• If stomach discomfort occurs, consider taking the tablet with food or after meals.
• Store the medication safely, away from children, in a cool and dry place.
• Regularly monitor your blood pressure and consult your doctor for any concerns.