LONGIFENE 120ML SYP

Buclizine, the active ingredient in Buclizine Syrup/Suspension, is an antihistamine that primarily exerts its effects by antagonizing H1 histamine receptors. This mechanism is crucial in alleviating symptoms associated with allergies and motion sickness. By blocking the H1 receptors, Buclizine prevents histamine from binding to these receptors, thereby reducing the effects of histamine release, such as itching, sneezing, and congestion. This action helps to alleviate symptoms related to allergic reactions and provides relief from motion sickness by suppressing the vestibular system's response to motion stimuli.

Buclizine

Antihistamine

Suspension

The following are the uses of Buclizine Syrup/Suspension:

• Used for controlling nausea and vomiting associated with motion sickness
• Used for treating vertigo and dizziness
• Used to relieve symptoms of inner ear disorders, such as Meniere's disease
• Used to reduce nausea and improve appetite in patients with anorexia
• Used for managing nausea and vomiting after surgery or during chemotherapy
• Used to provide relief from mild to moderate allergic reactions
• Used to prevent and treat nausea and vomiting during pregnancy (under medical supervision)
• Used to ease discomfort during travel for those prone to motion sickness

In the case of an overdose of Buclizine Syrup/Suspension, it is important to recognize the potential severity of this situation. Symptoms may include extreme drowsiness, confusion, and in severe cases, seizures. Prompt medical attention is necessary, as treatment may involve gastric lavage, administration of activated charcoal, and supportive care in a healthcare facility. It is crucial to seek medical help immediately to ensure the best possible outcome.

In the case of a missed dose of Buclizine Syrup/Suspension, it is important to take the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, consult your healthcare professional for advice on how to get back on track and ensure the medication's effectiveness. It is best to take the medication at evenly spaced intervals to maintain its therapeutic benefits.

To administer Buclizine Syrup/Suspension, shake the bottle vigorously, measure the prescribed dose with an accurate measuring device like a marked measuring spoon or oral syringe, and take it orally, either with or without food, following the dosage instructions provided by your healthcare professional or as indicated on the medication label.

Following are the conditions when Buclizine Syrup/Suspension should not be administered:

• Must not be given to individuals with a known allergy or hypersensitivity to Buclizine or any other antihistamines.
• Contraindicated in patients with a history of porphyria, a disorder affecting the skin and nervous system.
• Not suitable for individuals with glaucoma, as it may worsen the condition.
• Should not be used in patients with prostate enlargement or urinary retention.
• Must be avoided in patients with severe kidney impairment or end-stage kidney disease.
• Not recommended for infants and young children under 2 years of age.
• Contraindicated in patients with a history of seizures or epilepsy.
• Should not be administered to individuals with a known blood disorder, such as agranulocytosis or leukopenia.

The side effects of Buclizine Syrup/Suspension may include:

• Drowsiness or sedation
• Dry mouth
• Blurred vision or visual disturbances
• Constipation
• Nausea and vomiting
• Skin rash or itching
• Dizziness or loss of balance
• Confusion, especially in elderly individuals

Following are the precautions and warnings for Buclizine Syrup/Suspension:

• Allergic reactions may occur; individuals with a known or suspected allergy to Buclizine or related antihistamines should avoid this medication.
• Not recommended for infants and young children, especially those under 6 years old, due to potential side effects.
• Caution is advised for individuals with liver or kidney disease, as Buclizine metabolism may be affected.
• Elderly patients may be more susceptible to side effects, particularly drowsiness and dizziness.
• Avoid alcohol consumption while using Buclizine, as it can intensify side effects and impair coordination.
• Do not engage in activities requiring mental alertness, such as driving or operating machinery, if you experience drowsiness as a side effect.
• If symptoms persist or worsen, consult a healthcare professional immediately.

Following are the drug interactions for Buclizine Syrup/Suspension:

• Alcohol and other central nervous system (CNS) depressants (e.g., opioids, benzodiazepines) may increase the sedative effects of Buclizine, leading to enhanced drowsiness and impaired coordination.
• Antihistamines, such as diphenhydramine, can add to the drowsiness caused by Buclizine, potentially affecting alertness and driving ability.
• Buclizine may enhance the effects of anticholinergic medications, including certain antidepressants and antipsychotics, leading to increased side effects like dry mouth, blurred vision, and constipation.
• It can interact with anticoagulants like warfarin, potentially altering the blood's ability to clot and increasing the risk of bleeding.
• Concomitant use with other medications that prolong the QT interval (e.g., certain antibiotics, antifungals, and antipsychotics) may increase the risk of cardiac arrhythmias.
• Buclizine may reduce the effectiveness of antacids and H2-receptor antagonists, used for treating acid reflux, by decreasing their absorption.
• Caution is advised when combining Buclizine with medications that affect liver enzymes, as this may alter the metabolism and effectiveness of both drugs.

Following are the food interactions to consider with Buclizine Syrup/Suspension:

• Avoid consuming alcohol during the medication period, as it can intensify the drowsiness and dizziness associated with Buclizine.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit the metabolism of Buclizine, potentially leading to increased blood levels and a higher risk of side effects.
• Caffeine-rich foods and beverages like coffee, tea, and energy drinks may enhance the stimulant effects of Buclizine, causing increased alertness or insomnia.
• Dairy products and high-fat meals might slightly delay the absorption of Buclizine, but this is usually not clinically significant.
• Spicy foods might exacerbate gastrointestinal side effects like nausea or stomach discomfort, especially if taken shortly after consuming the medication.
• Consuming Buclizine with a light meal or snack can help reduce the likelihood of an upset stomach.
• Generally, Buclizine can be taken with or without food, but it's advisable to follow the prescription guidelines provided by your healthcare professional.

Buclizine Syrup/Suspension should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the syrup tightly sealed within its original container to maintain its integrity and prevent contamination. Avoid storage in bathrooms or near heat-emitting appliances like stoves or radiators, as temperature fluctuations can compromise the medication's quality. Prioritize the disposal of unused or expired syrup responsibly; refrain from flushing it or pouring it down the drain. Consult your pharmacist or healthcare provider for guidance on safe disposal practices. Always exercise caution to keep the medication out of children's reach to prevent accidental ingestion.

Following are the quick tips for Buclizine Syrup/Suspension:

• Administer the syrup as directed by your doctor or pharmacist.
• Ensure you measure the dose accurately using a calibrated measuring device.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Avoid taking more or less than the prescribed dose.
• Always check the expiration date before using the medication.
• Do not share your medication with others, even if they have similar symptoms.
• Contact your doctor if symptoms persist or worsen after taking the syrup.