LONGIFENE TAB

Buclizine is a first-generation antihistamine belonging to the piperazine class. Its primary mechanism of action is as a potent antagonist of H1 histamine receptors. By blocking these receptors, buclizine prevents the histamine-induced symptoms associated with allergies and inflammation. This action helps to alleviate symptoms such as itching, sneezing, and hives. Additionally, buclizine has mild anticholinergic properties, which contribute to its effectiveness in reducing motion sickness and nausea. It exerts its antiemetic effects by acting on the vestibular system in the brain, although the exact mechanism is not fully understood. The combined antihistaminic and anticholinergic actions of buclizine make it effective in managing various conditions, including allergies, rhinitis, and motion sickness.

Buclizine

Antihistamine

Tablet

The following are the uses of Buclizine Tablet:

• Used for preventing and treating motion sickness and vertigo
• Used for reducing nausea and vomiting associated with travel
• Used to relieve symptoms of inner ear conditions like Meniere's disease
• Used to manage dizziness and balance disorders
• Used for short-term treatment of vertigo symptoms
• Used as an antihistamine to reduce allergic reactions
• Used for its sedative effect to aid sleep during travel
• Used to prevent and manage nausea and dizziness in various medical conditions.

In the case of an overdose of Buclizine Tablets, it is important to recognize the signs and symptoms, which may include dizziness, confusion, and gastrointestinal disturbances. Prompt action is necessary, and medical advice should be sought immediately. Do not hesitate to contact emergency services or a healthcare professional, as they can provide guidance and support to manage the situation effectively. It is crucial to act swiftly to prevent potential complications.

In the case of a missed dose of Buclizine Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. It is crucial to maintain consistency in taking Buclizine Tablet as prescribed by your healthcare provider.

To take Buclizine Tablets, swallow the tablet whole with a full glass of water, preferably with or after a meal, following the dosage instructions provided by your healthcare professional, typically taken once or twice a day as directed.

Following are the conditions/situations when Buclizine Tablet should be avoided:

• Should not be used in individuals with a known allergy to Buclizine or any antihistamines.
• Contraindicated in patients with a history of porphyria (a disorder affecting certain enzymes in the body).
• Not recommended for individuals with glaucoma or increased intraocular pressure.
• Should not be used in patients with severe liver impairment.
• Avoid in patients with severe urinary retention or urinary obstruction.
• Contraindicated in patients with a history of epilepsy or seizures.
• Not suitable for individuals with a history of cardiac arrhythmias.

The side effects of Buclizine Tablet may include:

• Drowsiness or sedation
• Dry mouth
• Constipation
• Blurred vision
• Dizziness
• Nausea and vomiting
• Skin rashes

Following are the precautions and warnings for Buclizine Tablet:

• Avoid use in patients with known hypersensitivity to buclizine or any other ingredients in the tablet.
• May cause drowsiness; avoid driving, operating machinery, or performing tasks requiring alertness.
• Use with caution in patients with glaucoma, as it may increase intraocular pressure.
• Patients with urinary retention, prostate enlargement, or bladder obstruction should use with caution, as buclizine may worsen symptoms.
• May cause dry mouth, dizziness, or blurred vision; stay hydrated and avoid alcohol consumption.
• Use with caution in elderly patients, as they may be more sensitive to side effects like confusion or dizziness.
• Not recommended for children under the age of 6 unless prescribed by a healthcare provider.
• Patients with a history of epilepsy or seizure disorders should use with caution, as antihistamines may lower the seizure threshold.
• Avoid alcohol and other central nervous system depressants, as they may enhance drowsiness and sedation.
• Consult a doctor before use if pregnant or breastfeeding, as safety in these conditions is not well established.

Following are the drug interactions for Buclizine Tablet:

• Alcohol and other central nervous system (CNS) depressants can increase the sedative effects of Buclizine, leading to enhanced drowsiness and impaired coordination.
• It may interact with anticoagulants, such as warfarin, potentially altering the blood clotting process and requiring close monitoring of coagulation parameters.
• Buclizine can inhibit the metabolism of certain medications, including some antidepressants (e.g., selective serotonin reuptake inhibitors or SSRIs), which may result in increased drug levels and side effects.
• Caution is advised when combining Buclizine with other anticholinergic medications, as it can lead to increased side effects like dry mouth, blurred vision, and urinary retention.
• The effectiveness of Buclizine may be reduced when taken with antacids containing aluminum or magnesium, as these can decrease its absorption.
• Drugs that prolong the QT interval, such as certain antiarrhythmics or antipsychotics, should be used cautiously with Buclizine due to the potential for cardiac arrhythmias.
• It may interact with other antihistamines, resulting in additive drowsiness and impaired cognitive function.

Following are the food interactions for Buclizine Tablet:

• Alcohol should be avoided or consumed with caution as it may enhance the sedative effects of Buclizine, leading to increased drowsiness and impaired coordination.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit certain enzymes in the liver, potentially affecting the metabolism of Buclizine and increasing its concentration in the body.
• Dairy products and high-fat meals may slow down the absorption of Buclizine, leading to a delay in its effectiveness. Consider taking the medication on an empty stomach or as directed by your healthcare provider.
• Caffeine-rich foods and beverages should be limited as they may counteract the sedative effects of Buclizine, making it less effective for treating conditions like nausea and vertigo.
• Avoid eating large meals before or after taking Buclizine to prevent potential stomach discomfort and interference with drug absorption.
• Foods with high salt content should be minimized as Buclizine may cause water retention, and excessive salt intake can exacerbate this effect.
• If you have a history of liver or kidney problems, consult your doctor as they may provide specific dietary recommendations to support these organs while taking Buclizine.
• Always follow the advice of your healthcare provider regarding dietary restrictions or recommendations when using Buclizine.

Buclizine Tablets should be stored in a cool, dry place, preferably at room temperature, ensuring it stays below 25°C. Protect the tablets from direct exposure to sunlight and moisture to maintain their integrity. Always keep the medication in its original container, tightly sealed, to prevent contamination. Avoid placing the tablets in the bathroom or near heat-emitting appliances as temperature fluctuations can impact their effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult your pharmacist for guidance on proper disposal practices to protect the environment. Additionally, keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Buclizine Tablet:

• Take the tablet as directed by your doctor; do not exceed the prescribed dosage.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Take it at the same time each day to maintain consistent blood levels.
• If you experience dizziness, avoid driving or operating heavy machinery.
• Inform your doctor about all medications you are taking to avoid potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Consult your doctor if you are pregnant, breastfeeding, or planning a pregnancy before taking this medication.