Lopid (300mg) 100 Capsules

Gemfibrozil, the active ingredient in the 300mg capsule, primarily exerts its lipid-lowering effects by activating peroxisome proliferator-activated receptor alpha (PPAR-alpha). This activation results in the upregulation of lipoprotein lipase (LPL) and a decrease in the production of apolipoprotein C-III, leading to enhanced catabolism of triglyceride-rich particles. Consequently, the levels of low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL) are reduced, while high-density lipoprotein (HDL) levels are increased. This selective mechanism contributes to improved lipid profiles, making Gemfibrozil particularly effective in managing hypertriglyceridemia and mixed dyslipidemia.

Gemfibrozil 300mg

Fibrate cholesterol-lowering drug.

Capsule

The following are the uses of Gemfibrozil 300mg Capsule:

• Used for lowering high levels of triglycerides, a type of fat, in the blood.
• Used for treating dyslipidemia, a condition with abnormal levels of fats in the blood.
• Used for reducing the risk of developing atherosclerosis and its complications.
• Used for managing conditions where the body produces too much cholesterol.
• Used for improving cholesterol and triglyceride levels in patients with certain metabolic disorders.
• Used for preventing the progression of coronary heart disease.
• Used for maintaining healthy blood lipid levels in patients with a history of high cholesterol.

In the case of an overdose of Gemfibrozil 300mg Capsules, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and diarrhea. More severe cases can lead to muscle pain, weakness, and an increased risk of bleeding. It is important to seek medical assistance promptly if an overdose is suspected. Treatment for overdose may involve supportive care, including monitoring vital signs, providing intravenous fluids, and ensuring the patient's comfort and stability.

In the case of a missed dose of Gemfibrozil 300mg Capsule, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your medication schedule. It is advisable to set a reminder to help you stay on track with your medication routine.

To take Gemfibrozil 300mg Capsule, swallow the capsule whole with a full glass of water, preferably during a meal or as directed by your healthcare provider, typically twice a day, to help regulate your cholesterol levels.

Here are the conditions or situations when Gemfibrozil 300mg Capsule should not be taken:

• Avoid using if you are allergic to Gemfibrozil or other fibrate medications.
• Do not take this medication if you have severe kidney disease or are on dialysis.
• Contraindicated in individuals with gallbladder disease or gallstones.
• Should not be used if you have liver disease or severe liver impairment.
• Not recommended for patients with pancreatitis or a history of pancreatitis.
• Avoid if you have a rare inherited muscle disorder (myopathy).
• Do not take this medication if you are pregnant or breastfeeding.
• Gemfibrozil should not be used in children under 12 years of age.

The side effects of Gemfibrozil 300mg Capsule may include:

• Stomach pain or upset
• Nausea and vomiting
• Diarrhea or constipation
• Loss of appetite
• Headache
• Dizziness or lightheadedness
• Muscle pain or weakness
• Itching or skin rash

Following are the precautions and warnings for Gemfibrozil 300mg Capsule:

• Gemfibrozil should not be used in patients with known hypersensitivity or allergy to the drug or its components.
• Regular monitoring of liver function is necessary during treatment, and therapy should be discontinued if liver enzyme levels increase significantly.
• Patients with a history of gallstone disease should be monitored closely, as gemfibrozil can increase the risk of gallstone formation.
• Caution is advised in patients with kidney disease, as the drug's effects may be altered.
• Gemfibrozil may increase the risk of muscle-related side effects, especially when used with statins. Any muscle pain or weakness should be reported to the doctor immediately.
• This medication may affect blood sugar levels, so diabetic patients should monitor their blood glucose regularly.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as its safety during pregnancy and lactation is not fully established.
• Gemfibrozil may interact with other medications, including anticoagulants and cholesterol-lowering drugs, so a complete medical history should be provided to the healthcare provider.

Following are the drug interactions for Gemfibrozil 300mg Capsule:

• It can interact with other lipid-lowering agents like statins, increasing the risk of myopathy and rhabdomyolysis.
• Gemfibrozil may enhance the anticoagulant effect of warfarin, requiring close monitoring of INR (International Normalized Ratio).
• Concomitant use with oral hypoglycemic agents or insulin may result in increased hypoglycemic effects.
• When taken with ciclosporin, it can lead to increased ciclosporin levels and potential toxicity.
• Fibrates, including gemfibrozil, can increase the plasma concentrations of oral coumarin anticoagulants.
• Gemfibrozil may decrease the absorption of thyroid hormones, requiring dosage adjustments.
• It can also interact with bile acid sequestrants, reducing the effectiveness of both medications.

Following are the food interactions for Gemfibrozil 300mg Capsule:

• Avoid excessive alcohol consumption as it can increase the risk of liver-related side effects and may interfere with the medication's effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the levels of Gemfibrozil in the blood, potentially leading to an increased risk of muscle-related side effects.
• High-fat meals can increase the absorption of Gemfibrozil, potentially leading to higher blood levels of the medication and an increased risk of side effects.
• Avoid consuming large amounts of vitamin C-rich foods or supplements as they may decrease the effectiveness of Gemfibrozil.
• Dairy products like milk, cheese, and yogurt may interfere with the absorption of Gemfibrozil, so consider separating them by a few hours to ensure optimal absorption.
• Foods high in cholesterol and saturated fats should be limited as they can counteract the medication's lipid-lowering effects.
• Avoid consuming herbal supplements like garlic, ginkgo biloba, and ginseng without consulting your healthcare provider, as they may interact with Gemfibrozil.
• Always follow the dietary recommendations provided by your healthcare professional to ensure the medication's effectiveness and minimize potential interactions.

Gemfibrozil 300mg capsules should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect the capsules from excessive heat, moisture, and direct sunlight as these conditions can degrade the medication. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent exposure to air and humidity. When disposing of unused or expired capsules, do not throw them into the trash or flush them down the toilet. Instead, follow local guidelines for medication disposal, which may include returning them to a pharmacy or a designated collection point for safe disposal. Ensure that the medication is kept out of the reach of children and pets to prevent accidental ingestion.

Following are the quick tips for Gemfibrozil 300mg Capsule:

• Take the capsule as directed by your doctor, usually twice a day.
• Swallow the capsule whole with a full glass of water; do not crush or chew.
• Take it consistently at the same time(s) each day to maintain stable blood levels.
• You can take it with or without food, but be consistent with your choice.
• Avoid grapefruit and grapefruit juice as they may interact with the medication.
• Inform your doctor about all the medications you are taking to prevent potential drug interactions.
• Store the capsules at room temperature, away from moisture and light.