LORTAB 10MG TAB

Acetaminophen and hydrocodone bitartrate combination therapy acts by targeting two different mechanisms in the body. Acetaminophen, a non-opioid analgesic, primarily exerts its effect through inhibiting the synthesis of prostaglandins, which are involved in pain and inflammation signaling. It blocks cyclooxygenase (COX) enzymes, particularly COX-2, thus reducing the production of prostaglandins and providing pain relief. On the other hand, hydrocodone bitartrate is an opioid analgesic that binds to opioid receptors in the central nervous system, primarily the mu-opioid receptors. This binding leads to a decrease in the perception of pain signals and an increased pain threshold, resulting in analgesia. The combination of these two mechanisms provides effective pain relief, with acetaminophen addressing peripheral pain pathways and hydrocodone addressing central pain pathways.

acetaminophen, Hydrocodone bitartrate 10MG

Opioid analgesic

Tablet

The following are the uses of acetaminophen, Hydrocodone bitartrate 10MG Tablet:

• Used for relieving moderate to severe pain
• Used to treat acute pain following a surgery or injury
• Used to manage chronic pain conditions
• Used for reducing fever and pain associated with inflammation
• Used to provide around-the-clock pain relief
• Used as a short-term pain management solution
• Used under the supervision of a healthcare professional due to its potential for addiction

In the case of an overdose of acetaminophen and Hydrocodone bitartrate 10MG tablets, prompt medical attention is necessary. Symptoms may include nausea, vomiting, dizziness, and liver damage. The severity of the overdose can vary, with liver toxicity being a significant concern. Quick action is vital to prevent potential harm, and medical professionals should be contacted immediately to provide appropriate treatment and support. Immediate assessment and management can help mitigate the risks associated with this type of overdose.

In the case of a missed dose of acetaminophen and Hydrocodone bitartrate 10MG Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. For acute pain, take the missed dose if needed, but ensure you leave enough time before the next scheduled dose to avoid exceeding the maximum daily dose.

To take acetaminophen and Hydrocodone bitartrate 10MG tablets, swallow the tablet whole with a glass of water, following the prescribed dosage instructions provided by your healthcare professional, typically taken every 4 to 6 hours as needed for pain relief, without crushing, chewing, or breaking the tablet.

Here are the situations or conditions when Acetaminophen and Hydrocodone Bitartrate 10MG Tablet should not be taken:

• Do not take if you have a known allergy or hypersensitivity to acetaminophen, hydrocodone, or any other components in the medication.
• Avoid using this medication if you have severe asthma, respiratory depression, or acute or severe bronchial asthma.
• Not suitable for individuals with liver impairment or severe liver disease.
• Contraindicated in patients with a history of head injury or increased intracranial pressure.
• Should not be used in patients with gastrointestinal conditions like bowel obstruction or pancreatitis.
• Do not use if you have a history of or are at risk for seizures.
• Avoid using this medication if you have a history of alcohol or substance abuse.
• Not recommended for individuals with certain metabolic disorders like hyperglycinemia.
• Should not be combined with MAO inhibitor medications or within 14 days of stopping them.
• Avoid if you have difficulty urinating or have a blockage in your stomach or intestines.
• Do not use if you have recently had or are scheduled for surgery.

The side effects of Acetaminophen and Hydrocodone bitartrate 10MG Tablet may include:

• Dizziness or lightheadedness
• Nausea and vomiting
• Constipation
• Dry mouth
• Impaired coordination or drowsiness
• Itching or skin rash
• Slowed or difficult breathing
• Confusion or anxiety

Following are the precautions and warnings for acetaminophen and Hydrocodone bitartrate 10MG Tablet:

• Do not exceed the recommended dosage as it may lead to liver damage, especially in patients with pre-existing liver conditions.
• This medication contains hydrocodone, an opioid, which can be habit-forming. It should be used cautiously and only as directed to reduce the risk of addiction or abuse.
• Patients with a history of respiratory issues should exercise caution as opioids can cause respiratory depression.
• Avoid alcohol consumption while taking this medication, as it may enhance the sedative effects and increase the risk of accidents.
• Elderly patients may be more sensitive to the side effects; therefore, close monitoring is necessary.
• Do not operate heavy machinery or drive until you know how this medication affects you, as it can cause dizziness and impair your judgment.
• Inform your healthcare provider of any other medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Acetaminophen and Hydrocodone Bitartrate 10mg Tablet:

• Alcohol and other central nervous system (CNS) depressants (e.g., benzodiazepines, barbiturates) can increase the risk of respiratory depression and sedation.
• The risk of hepatotoxicity may increase when combined with other acetaminophen-containing products or alcohol.
• May interact with mixed agonist/antagonist opioids (e.g., pentazocine, nalbuphine), causing reduced analgesic effect or withdrawal symptoms.
• Monoamine oxidase inhibitors (MAOIs) can lead to serious adverse reactions, and their use should be separated from opioids by at least 14 days.
• Hydrocodone may enhance the effects of other CNS depressants like muscle relaxants and general anesthetics, requiring close monitoring.
• Anticonvulsants such as carbamazepine and phenytoin can decrease the effectiveness of hydrocodone.
• Antihistamines and other medications with anticholinergic properties may increase the risk of urinary retention and other anticholinergic side effects.

Following are the food interactions for Acetaminophen and Hydrocodone bitartrate 10MG Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can interfere with the metabolism of Hydrocodone, potentially leading to increased drug levels and prolonged effects.
• Alcohol should be strictly avoided as it can enhance the sedative effects of Hydrocodone, increasing the risk of respiratory depression, impaired motor skills, and cognitive function.
• High-fat meals may delay the absorption of Hydrocodone, potentially affecting its onset of action. It's advisable to maintain a consistent diet to ensure stable drug levels.
• Avoid caffeine-rich foods and beverages as they can increase the risk of liver damage when combined with Acetaminophen, especially with prolonged or excessive use.
• Do not consume natural licorice as it may contain glycyrrhizin, which can potentially interact with Hydrocodone and increase the risk of side effects.
• Be cautious with foods containing tyramine (aged cheeses, cured meats) as they may interact with Hydrocodone, potentially causing elevated blood pressure.
• Inform your healthcare provider about any herbal supplements or natural remedies you use, as some may interact with Hydrocodone and affect its metabolism.
• Always follow the dosage instructions provided by your healthcare professional, and be cautious when combining this medication with any dietary substances.

Acetaminophen, Hydrocodone bitartrate 10MG Tablets should be stored in a secure and dry location, preferably in a locked cabinet or container, to prevent misuse or accidental ingestion. Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain their integrity. Avoid exposure to excessive heat, moisture, or direct sunlight, as it can degrade the medication. It is crucial to regularly check the expiration date on the packaging and properly dispose of any expired or unused tablets. When disposing of the medication, do not flush it down the toilet or throw it into the trash; instead, follow local guidelines or consult your pharmacist for safe disposal options. Keep the medication away from children and pets to prevent accidental exposure.

Following are the quick tips for acetaminophen, Hydrocodone bitartrate 10MG Tablet:

• Consult your healthcare provider for dosage instructions specific to your condition.
• Ensure you understand the prescribed dosage and duration of treatment.
• Take the tablet with a full glass of water to aid in swallowing.
• Avoid crushing or chewing the tablet; swallow it whole for optimal absorption.
• Maintain a consistent daily routine for taking the medication as directed.
• Do not increase the dosage without medical advice, even if you feel the medication is not working.
• Store the medication safely, away from children and pets, at room temperature.