Loxiget (0.3%) 3.5g Eye Ointment

Gatifloxacin Ointment primarily acts by inhibiting DNA gyrase, a type II topoisomerase enzyme essential for bacterial DNA replication, transcription, and repair. The medication binds to the A subunit of DNA gyrase, blocking its ability to introduce negative supercoils into DNA, which is necessary for the DNA to unwind and replicate. This action leads to the disruption of bacterial DNA synthesis and ultimately results in bacterial cell death. By specifically targeting DNA gyrase, gatifloxacin effectively inhibits the growth and proliferation of susceptible bacteria, particularly those causing eye infections.

Gatifloxacin

fluoroquinolone antibiotic.

Ointment

The following are the uses of Gatifloxacin Ointment:

• Used for treating bacterial conjunctivitis, an inflammation or infection of the eye.
• Used for preventing bacterial infections after eye injuries or eye surgeries.
• Used to alleviate symptoms like itching, redness, and discharge associated with eye infections.
• Used to stop the spread of certain bacteria in the eye, promoting faster healing.
• Used for its broad-spectrum activity against various bacteria causing eye infections.
• Used as an alternative treatment when other antibiotics are not effective or tolerated.

In the case of an overdose of Gatifloxacin Ointment, it is important to remain calm and take immediate action. Seek medical assistance promptly and provide the healthcare professional with all relevant information, including the amount of ointment used and the time of the overdose. They will be able to assess the situation and provide the necessary treatment to manage any adverse effects. It is crucial to act quickly to minimize potential risks and ensure the best possible outcome.

In the case of a missed dose of Gatifloxacin Ointment, it is important to apply the medication as soon as you remember. If it's almost time for your next scheduled dose, skip the missed one. Do not apply extra ointment to make up for the missed dose, as this may increase the risk of side effects. Simply resume your regular dosing schedule and ensure you don't miss any further doses. If you frequently miss doses, consider setting reminders or alarms to help you stay on track with your medication regimen.

To apply Gatifloxacin Ointment, wash your hands thoroughly, gently pull down the lower eyelid to create a pocket, and place a thin layer of the ointment into the conjunctival sac, repeating for the other eye if instructed, typically two to eight times daily or as directed by your healthcare professional.

Following are the conditions or circumstances when Gatifloxacin Ointment should not be applied:

• Avoid using if you have a known allergy or hypersensitivity to Gatifloxacin or any other quinolone antibiotics.
• Do not use in the presence of a confirmed or suspected bacterial corneal ulcer.
• Not suitable for individuals with a history of tendon disorders or tendon rupture.
• Should not be used in patients with a history of epilepsy or seizures.
• Avoid using if you have a history of sensitivity to light (photosensitivity).
• Contraindicated in individuals with a confirmed or suspected corneal epithelial defect.
• Not recommended for those with a history of severe liver or kidney disease.

The side effects of Gatifloxacin Ointment may include:

• Itching or irritation at the application site
• Redness or swelling of the eyelids
• Eye discomfort or dryness
• Blurred vision
• Sensitivity to light (photophobia)
• Headache
• Allergic reactions (skin rash, itching, severe dizziness)
• Increased eye pressure (in rare cases)

Following are the precautions and warnings for Gatifloxacin Ointment:

• Avoid contact with eyes and mucous membranes. If accidental contact occurs, immediately rinse with water.
• Do not use Gatifloxacin Ointment if you are allergic to any of its ingredients.
• This medication is for external use only. Do not swallow or ingest.
• Do not apply to open wounds, broken skin, or large areas of skin without medical advice.
• Discontinue use and consult a healthcare professional if you experience severe itching, burning, or skin irritation.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.
• Inform your doctor about all other medications you are using to avoid potential drug interactions.

Following are the drug interactions for Gatifloxacin Ointment:

• Gatifloxacin may decrease the effectiveness of live bacterial vaccines (e.g., BCG, typhoid) and live viral vaccines (e.g., measles, mumps, rubella). Avoid simultaneous use.
• Topical corticosteroids may increase the risk of bacterial or fungal infections when used with Gatifloxacin. Monitor for signs of infection.
• The use of other topical ophthalmic medications should be separated by at least 5 minutes to prevent washout.
• Gatifloxacin may increase the effects of anticoagulants like warfarin, requiring close monitoring of INR.
• Drugs that prolong the QT interval, such as certain antiarrhythmics or antipsychotics, may increase the risk of cardiac arrhythmias when used with Gatifloxacin.
• The use of systemic fluoroquinolones may enhance the effects of oral antihyperglycemic agents, potentially leading to hypoglycemia. Monitor blood glucose levels.
• Gatifloxacin may increase the concentration of cyclosporine, requiring close monitoring of cyclosporine levels.

Following are the food interactions for Gatifloxacin Ointment:

• Gatifloxacin should be used with caution in patients who consume caffeine, as it can increase the risk of caffeine-related side effects like nervousness, anxiety, and insomnia.
• Avoid consuming large amounts of chocolate while using this medication, as chocolate contains caffeine and compounds that may interfere with the absorption of Gatifloxacin.
• Alcohol consumption is not recommended, as it may increase the risk of liver-related side effects and may also impair the effectiveness of the medication.
• Grapefruit and grapefruit juice are known to interact with many medications, but with Gatifloxacin, the interaction is less significant. However, to be cautious, it's best to avoid consuming large amounts of grapefruit products.
• Dairy products like milk, yogurt, and cheese may decrease the absorption of Gatifloxacin. It is advisable to separate the medication and dairy intake by a few hours.
• Avoid high-fat meals, as they can slow down the absorption of Gatifloxacin and may potentially reduce its effectiveness.
• Always stay well-hydrated by drinking plenty of water while using Gatifloxacin to support the overall healing process.
• Consult your healthcare provider for personalized advice on dietary restrictions and potential food interactions, especially if you have a history of gastrointestinal issues or are taking other medications.

Gatifloxacin Ointment should be stored with utmost care to maintain its integrity and effectiveness. Keep the ointment in a cool, dry place, preferably at room temperature, ensuring it is shielded from direct sunlight and heat sources like radiators or ovens. It's crucial to store the medication in its original container, tightly sealed, to prevent contamination. Always check the expiration date, and never use the ointment beyond this date. When it's time to discard the ointment, do not flush it or pour it down the drain. Instead, consult a pharmacist or healthcare professional for the recommended disposal method to ensure environmental safety. Keep the medication out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Gatifloxacin Ointment:

• Wash your hands thoroughly before applying the ointment to maintain hygiene.
• Apply a thin layer to the affected eye area as directed by your doctor.
• Gently pull down the lower eyelid and place the ointment inside the lower lid using the applicator.
• Avoid touching the tip of the tube to your eye or any surface to prevent contamination.
• Do not wear contact lenses while using the ointment; wait until your eye heals.
• Continue the full course of treatment even if symptoms improve, unless advised otherwise by your doctor.
• Store the ointment at room temperature, away from direct sunlight and moisture.