LUCRIN 11.25MG DEPOT

Leuprorelin injection works by mimicking the body's natural gonadotropin-releasing hormone (GnRH). When administered, leuprorelin initially stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). However, with continued use, it desensitizes the pituitary gland, leading to a decrease in the production of LH and FSH. This suppression of gonadotropin release results in decreased testosterone production in men and reduced estrogen production in women, making it effective in treating hormone-sensitive conditions such as prostate cancer and endometriosis.

Leuprorelin

GnRH agonist.

Injection

The following are the uses of Leuprorelin Injection:

• Used for treating prostate cancer by suppressing testosterone production.
• Used in managing advanced breast cancer by controlling estrogen levels.
• Used to treat endometriosis by reducing the growth of endometrial tissue.
• Used for managing uterine fibroids, helping to shrink and control symptoms.
• Used in certain fertility treatments to regulate hormones and support IVF.
• Used for early puberty treatment, helping to delay further development.
• Used in specific cases of anemia to regulate blood cell production.
• Used to prevent premature ovulation in controlled ovarian stimulation.

In the case of an overdose of Leuprorelin Injection, it is important to monitor for potential side effects, which may include increased hot flashes, mood changes, and temporary worsening of existing symptoms. Seek medical advice promptly and inform the healthcare professional about the extent of the overdose. They will provide guidance on managing any adverse reactions and may recommend supportive care to address specific symptoms that arise from the excess medication.

In the case of a missed dose of Leuprorelin Injection, it is important to contact your healthcare provider for guidance. The action you take will depend on how close it is to the time of your next scheduled dose. Generally, if the missed dose is noticed within a few hours of the scheduled time, you can administer the injection as soon as possible. However, if it's almost time for your next dose, it's best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

To administer Leuprorelin Injection, clean the injection site with an alcohol swab, insert the needle subcutaneously or intramuscularly as directed by your healthcare provider, inject the prescribed volume of the medication, and safely dispose of the used needle and syringe after the injection.

Here are the conditions or situations when Leuprorelin Injection should not be used:

• Should not be used in individuals with a known hypersensitivity or allergy to GnRH (Gonadotropin-Releasing Hormone) analogs like leuprorelin or any other ingredients in the injection.
• Contraindicated in women who are pregnant as it can cause birth defects and pregnancy complications.
• Not recommended for use during breastfeeding as it may suppress lactation.
• Should not be used in individuals with uncontrolled or untreated severe liver disease.
• Not suitable for patients with uncontrolled or untreated severe kidney disease.
• Contraindicated in women with undiagnosed vaginal bleeding or endometrial cancer.
• Should be avoided in individuals with uncontrolled diabetes, as it may affect blood sugar control.
• Not recommended for use in children, especially those with precocious puberty, unless advised by a specialist.
• Should not be used in patients with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Contraindicated in individuals with a history of heart disease or stroke, as it may increase the risk of cardiovascular events.
• Not suitable for women with untreated advanced endometriosis or uterine fibroids.

The side effects of Leuprorelin Injection may include:

• Hot flashes
• Night sweats
• Fatigue and weakness
• Headaches
• Mood changes, including depression or irritability
• Difficulty concentrating
• Bone pain or joint stiffness
• Decreased sexual interest or ability

Following are the precautions and warnings for Leuprorelin Injection:

• Not suitable for patients with hypersensitivity to leuprorelin, other GnRH agonists, or any injection components, as it may cause severe allergic reactions.
• Caution is required in patients with a history of cardiovascular diseases, as it may increase the risk of heart attack, stroke, and sudden cardiac death.
• May cause an initial hormone surge, leading to worsening symptoms in conditions like prostate cancer, endometriosis, or uterine fibroids before improvement occurs.
• Use with caution in patients with osteoporosis or those at risk of bone density loss, as long-term use may lead to decreased bone mineral density.
• Patients with diabetes should be monitored closely, as it may affect blood glucose levels.
• May cause mood changes, depression, or suicidal thoughts; patients should report any psychiatric symptoms to their healthcare provider.
• Can lead to injection site reactions, including pain, redness, or swelling; seek medical attention if severe reactions occur.
• In women, it may cause temporary menopause-like symptoms such as hot flashes, vaginal dryness, and menstrual irregularities.
• Not recommended for use in pregnant or breastfeeding women, as it may cause harm to the fetus or newborn.
• Regular monitoring of hormone levels, liver function, and bone health is advised during long-term therapy.

Following are the drug interactions for Leuprorelin Injection:

• Concurrent use with other GnRH agonists or antagonists may lead to an additive effect and increase the risk of side effects.
• Leuprorelin can interact with androgens or anabolic steroids, potentially reducing the effectiveness of these medications.
• It may decrease the efficacy of estrogens or progestins when used for hormone replacement therapy.
• The effects of anticoagulants like warfarin may be altered, requiring close monitoring of coagulation parameters.
• Leuprorelin can enhance the effects of insulin and oral hypoglycemic agents, leading to potential hypoglycemia.
• Drugs that affect liver function may influence the metabolism of Leuprorelin, possibly affecting its efficacy.
• Caution is advised when using Leuprorelin with medications that lower the seizure threshold, as it may increase the risk of seizures.

Following are the food interactions for Leuprorelin Injection:

• Avoid consuming grapefruit and grapefruit juice as they can interfere with the medication's metabolism, potentially leading to increased blood levels of Leuprorelin.
• Alcohol consumption should be limited or avoided as it may increase the risk of side effects and can interact with the medication's action, affecting hormone levels.
• Caffeinated beverages like coffee and tea might influence the absorption of Leuprorelin, so it's advisable to minimize their intake.
• Avoid high-fat meals as they can delay the absorption of the medication and potentially affect its efficacy.
• Ensure a balanced diet rich in nutrients, as Leuprorelin may impact bone density and overall health.
• Stay well-hydrated by drinking adequate water, especially if experiencing any gastrointestinal side effects.
• Avoid excessive salt intake, as Leuprorelin can affect fluid balance in the body.
• Consult a healthcare professional for personalized dietary advice, especially if you have specific health conditions or concerns.

Leuprorelin Injection should be stored properly to maintain its effectiveness and safety. It is recommended to store the injection in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F). Ensure that the injection is protected from light and kept in its original packaging until ready for use. Do not freeze the medication as it may affect its potency. Once the injection is opened, it should be used immediately, and any unused portion should be discarded properly. Disposal of Leuprorelin Injection should be done in accordance with local regulations and guidelines. Contact your healthcare provider or pharmacist for guidance on proper disposal methods to ensure environmental safety. Keep the medication out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Leuprorelin Injection:

• Administer the injection as directed by your healthcare professional.
• Ensure the injection is given at the correct time interval as prescribed.
• Gently swirl the vial before use to ensure the medication is properly mixed.
• Use a new needle and syringe for each injection to maintain sterility.
• Dispose of used needles and syringes safely in a sharps container.
• Inform your doctor if you experience any unusual symptoms or side effects.
• Store the medication as directed on the package insert.