Ludiomil (25mg) 30 Tablets

Maprotiline 25mg Tablet primarily exerts its therapeutic effects through its action on norepinephrine and, to a lesser extent, serotonin in the brain. It is a tetracyclic antidepressant that primarily inhibits the reuptake of norepinephrine, leading to increased concentrations of norepinephrine in the synaptic cleft. This enhancement of norepinephrine activity is believed to be responsible for the antidepressant, anxiolytic, and sedative effects observed with maprotiline. By modulating norepinephrine, maprotiline influences various neurotransmitter systems, helping to alleviate symptoms of depression and anxiety. Additionally, maprotiline's weak blockade of serotonin reuptake may contribute to its overall therapeutic profile, although this action is considered less significant compared to its norepinephrine reuptake inhibition.

Maprotiline 25mg

Tetracyclic antidepressant.

Tablet

The following are the uses of Maprotiline 25mg Tablet:

• Used for treating major depressive disorder, offering relief from symptoms like persistent sadness and loss of interest.
• Used for effectively managing depression, helping individuals regain energy and improve mood.
• Used for alleviating anxiety associated with depression, promoting a sense of calm and relaxation.
• Used for enhancing sleep quality by addressing insomnia related to depression.
• Used for restoring appetite and addressing weight changes caused by depression.
• Used for improving concentration and decision-making abilities compromised by depressive episodes.
• Used for providing relief from physical symptoms such as fatigue and chronic pain linked to depression.
• Used for supporting overall well-being, enabling individuals to manage depression and improve their quality of life.

In the case of an overdose of Maprotiline 25mg Tablets, symptoms may include severe drowsiness, confusion, seizures, and even cardiac arrest. The severity of the overdose depends on the amount ingested and individual factors. If an overdose is suspected, prompt medical intervention is necessary. Treatment may involve gastric lavage, administration of activated charcoal, and supportive care to manage symptoms and stabilize vital functions. It is crucial to seek medical help immediately if an overdose is suspected.

In the case of a missed dose of Maprotiline 25mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take Maprotiline 25mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, and do not crush or chew the tablet.

Here are the conditions or situations when Maprotiline 25mg Tablet should not be used:

• Should not be taken by individuals with a known allergy to Maprotiline or any of the tetracyclic antidepressants.
• Contraindicated in patients with a history of seizures or epilepsy.
• Not suitable for individuals with severe liver or kidney impairment.
• Should be avoided in patients with a history of urinary retention or glaucoma.
• Must not be used in patients with a recent heart attack or those with severe heart disease.
• Contraindicated during pregnancy and breastfeeding.
• Not recommended for children below 16 years of age.
• Should not be combined with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment.
• Avoid if you have a history of blood disorders or low white blood cell count.
• Do not use if you have a history of narrow-angle glaucoma.

The side effects of Maprotiline 25mg Tablet may include:

• Dizziness
• Dry mouth
• Fatigue and drowsiness
• Constipation
• Blurred vision
• Increased heart rate
• Confusion
• Skin rash

Following are the precautions and warnings:

• Maprotiline 25mg Tablet should not be used in patients with a known hypersensitivity or allergy to maprotiline or any of its excipients.
• Patients with a history of seizures or epilepsy should exercise caution as this medication may lower the seizure threshold.
• It is crucial to monitor blood sugar levels regularly, as maprotiline can alter glucose metabolism.
• Maprotiline may cause dizziness or lightheadedness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• The medication should be used with caution in patients with cardiovascular diseases, as it may affect heart rhythm and blood pressure.
• Elderly patients may be more susceptible to side effects; regular monitoring is recommended.
• Maprotiline should be discontinued gradually to minimize the risk of withdrawal symptoms.
• Patients with liver or kidney impairment may require dosage adjustments, and regular monitoring of liver and kidney function is advised.

Following are the drug interactions for Maprotiline 25mg Tablet:

• Concomitant use with other antidepressants like SSRIs, MAOIs, or tricyclic antidepressants can lead to increased side effects and potential serotonin syndrome.
• Alcohol and sedative medications should be avoided as Maprotiline can enhance their effects, causing excessive drowsiness and impaired coordination.
• It may interact with drugs metabolized by CYP2D6 enzymes, such as certain antipsychotics and beta-blockers, leading to increased levels of these medications.
• Maprotiline can increase the effects of anticoagulants, including warfarin, requiring close monitoring of blood clotting time.
• The effectiveness of hypertension medications, such as beta-blockers and diuretics, may be reduced when used with Maprotiline.
• Anticonvulsant medications like phenytoin and carbamazepine may have decreased efficacy when taken with Maprotiline.
• Caution is advised when combining Maprotiline with antihistamines, as it may increase the risk of anticholinergic side effects.

Following are the food interactions to consider with Maprotiline 25mg Tablet:

• Avoid consuming alcohol during the treatment as it can increase the risk of side effects, especially drowsiness and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the levels of Maprotiline in the blood, leading to potential toxicity.
• Caffeine-rich beverages like coffee and tea might need to be reduced as Maprotiline can increase their effects, causing excessive nervousness and rapid heartbeat.
• Foods high in tyramine, such as aged cheeses, cured meats, and certain types of beer, should be avoided as Maprotiline can interact with tyramine, leading to a sudden increase in blood pressure.
• Avoid eating heavy meals, especially those high in fats, as they may slow down the absorption of Maprotiline.
• It is generally recommended to maintain a balanced diet and stay well-hydrated during the course of treatment.
• Always follow the advice of your healthcare provider regarding dietary considerations while taking this medication.

Maprotiline 25mg Tablets should be stored in a secure and dry location, away from direct sunlight and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid storing it in humid areas like bathrooms or near heat-emitting appliances, as temperature fluctuations can impact the drug's effectiveness. Regularly check the expiration date, and if the tablets are expired or no longer needed, do not flush them or pour them down the drain. Consult your pharmacist or healthcare professional for guidance on safe disposal methods. It is crucial to keep all medications, including Maprotiline, out of children's reach to prevent accidental consumption.

Following are the quick tips for Maprotiline 25mg Tablet:

• Take the tablet as directed by your doctor; do not alter the dosage without medical advice.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Maintain a consistent daily routine for taking the medication at the same time each day.
• Ensure you complete the full prescribed course, even if you feel better early on.
• Avoid alcohol consumption as it may cause excessive drowsiness or dizziness.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the medication at room temperature, away from moisture and light.