Luzon-3 (3mg) 100 Tablets

Lorazepam 3mg tablets exert their therapeutic effects primarily through enhancing the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system. This mechanism of action is attributed to lorazepam's high affinity for GABA receptors, particularly the GABAA receptors. By binding to these receptors, lorazepam facilitates the opening of chloride ion channels, leading to an influx of chloride ions into the neurons. This hyperpolarizes the cell membrane, making it more difficult for the neurons to become excited and transmit signals. As a result, lorazepam reduces neuronal excitability, anxiety, and the spread of seizure activity, thereby producing its anxiolytic and anticonvulsant effects.

Lorazepam 3mg

Benzodiazepine.

Tablet

The following are the uses of Lorazepam 3mg Tablet:

• Used for managing severe anxiety disorders, providing quick relief during panic attacks.
• Used for treating insomnia, aiding in falling asleep and staying asleep.
• Used for pre-operative sedation to reduce anxiety before surgeries or medical procedures.
• Used for managing seizures, especially in emergency situations.
• Used for aiding in alcohol withdrawal, reducing symptoms and preventing complications.
• Used for providing sedation and amnesia in certain medical procedures or diagnostic tests.
• Used for alleviating nausea and vomiting caused by chemotherapy treatments.
• Used for managing muscle spasms and providing relaxation in certain medical conditions.

In the case of an overdose of Lorazepam 3mg Tablets, individuals may experience severe symptoms such as profound drowsiness, confusion, and impaired coordination. Respiratory depression, where breathing becomes slow and shallow, is a significant concern. It can lead to a life-threatening condition if not addressed promptly. Prompt medical intervention is vital, as healthcare professionals can provide supportive care, monitor vital signs, and administer appropriate treatment to manage the overdose and prevent potential complications.

In the case of a missed dose of Lorazepam 3mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication. It is advisable to set reminders or use a pill organizer to help you remember to take your medication as prescribed.

To take Lorazepam 3mg Tablet, place the tablet on your tongue and allow it to dissolve naturally, preferably without chewing or crushing, and it can be taken with or without food as directed by your healthcare professional, ensuring you follow the prescribed dosage and administration instructions provided.

Here is a list of conditions and situations when Lorazepam 3mg Tablets should not be used:

• Allergy Should not be used in patients with a known or suspected allergy to Lorazepam or any other benzodiazepines.
• Respiratory Issues Contraindicated in patients with severe respiratory insufficiency or sleep apnea, as it can worsen breathing difficulties.
• Acute Narrow-Angle Glaucoma Lorazepam should not be administered to individuals with acute narrow-angle glaucoma.
• Severe Liver Impairment It is not recommended for patients with severe liver impairment or acute liver disease, as it may lead to increased drug toxicity.
• Pregnancy and Breastfeeding Avoid use during pregnancy, especially in the first and last trimesters, due to potential risks to the fetus. Also, it is not advised for breastfeeding mothers as it can pass into breast milk.

The side effects of Lorazepam 3mg Tablet may include:

• Drowsiness or sedation
• Confusion or disorientation
• Weakness and dizziness
• Unsteadiness and lack of coordination
• Memory problems or amnesia
• Slowed breathing or respiratory depression
• Allergic reactions (skin rash, itching, swelling)
• Changes in appetite and weight

Here are the precautions and warnings for Lorazepam 3mg Tablet:

• Do not consume alcohol while taking this medication, as it can intensify the sedative effects and impair your ability to function.
• Patients with a history of respiratory issues, such as chronic obstructive pulmonary disease (COPD), should use this medication with caution as it may worsen breathing difficulties.
• Lorazepam can cause dizziness and drowsiness; avoid activities requiring mental alertness like driving or operating heavy machinery.
• Elderly individuals are more sensitive to the effects of this medication and may experience more severe side effects, including confusion and unsteadiness.
• This medication should be used with caution in patients with liver or kidney disease, as it is metabolized by the liver and excreted by the kidneys.
• Do not abruptly stop taking Lorazepam as it may lead to withdrawal symptoms; consult your doctor for a proper tapering schedule.
• Pregnant and breastfeeding women should consult their healthcare provider before using Lorazepam, as it can potentially cause harm to the fetus or infant.
• Keep this medication out of reach of children and pets, and store it in a safe and secure place.

Following are the drug interactions for Lorazepam 3mg Tablet:

• Alcohol and other CNS depressants (e.g., opioids, antipsychotics) can increase the sedative effects of lorazepam, potentially leading to respiratory depression and impaired cognitive function.
• Lorazepam may enhance the effects of other medications that induce drowsiness, such as antihistamines and certain antidepressants.
• The effects of anticonvulsant medications may be altered by lorazepam, requiring close monitoring of seizure control.
• Drugs that inhibit certain liver enzymes (e.g., CYP3A4 inhibitors) can increase the concentration of lorazepam in the body, leading to prolonged sedation and other side effects.
• Combining lorazepam with clozapine may result in excessive sedation, respiratory depression, and hypotension.
• Macrolide antibiotics, azole antifungals, and certain antidepressants can inhibit the metabolism of lorazepam, leading to increased drug levels and potential toxicity.
• Lorazepam may reduce the effectiveness of levodopa in Parkinson's disease, requiring dosage adjustments.

Following are the food interactions for Lorazepam 3mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they can increase the concentration of Lorazepam in the blood, potentially leading to increased sedation and impaired motor skills.
• Alcohol consumption should be minimized or avoided as it can enhance the sedative effects of Lorazepam, causing excessive drowsiness and affecting your ability to perform tasks that require alertness.
• Caffeine intake should be monitored as it can counteract the sedative effects of Lorazepam, making it less effective and potentially leading to increased anxiety or insomnia.
• Fatty foods may slow down the absorption of Lorazepam, delaying its onset of action. It is advisable to take the medication on an empty stomach for quicker absorption.
• Avoid consuming large meals immediately after taking Lorazepam as it may affect the drug's absorption and distribution.
• Certain herbal supplements like St. John's Wort can reduce the effectiveness of Lorazepam by influencing its metabolism. Consult your healthcare provider about potential herb-drug interactions.
• Avoid foods that may cause allergies or gastrointestinal discomfort, as Lorazepam can sometimes affect the body's response to allergic reactions.

Lorazepam 3mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, ensuring they are out of the reach of children and pets. Maintain a consistent room temperature, avoiding exposure to excessive heat, moisture, or direct sunlight, as these conditions can degrade the medication's quality. Do not store it in the bathroom or kitchen, as these areas may have temperature fluctuations. Always keep the tablets in their original container, tightly sealed, to prevent contamination and maintain their effectiveness. When disposing of unused or expired tablets, do not flush them down the toilet or throw them into the trash. Instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for guidance on safe disposal methods to protect the environment and prevent misuse. Proper storage and disposal practices are crucial for the safe management of Lorazepam tablets.

Following are the quick tips for Lorazepam 3mg Tablet:

• Consult your doctor or pharmacist for personalized instructions.
• Swallow the tablet whole; do not crush, chew, or break it.
• Take it with a full glass of water for easy swallowing.
• Do not abruptly stop taking this medication; follow your doctor's instructions for tapering.
• Inform your doctor about all medications you're taking to prevent interactions.
• Store the medication at room temperature, away from light and moisture.
• Keep a record of your refills and renew your prescription as needed.