M-Low Plus (5/12.5mg) 20 Tablets

Hydrochlorothiazide and Amiloride are combined in this tablet to achieve a synergistic effect on blood pressure regulation. Hydrochlorothiazide, a thiazide diuretic, inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule of the kidneys, promoting the excretion of water and reducing blood volume, which in turn lowers blood pressure. Amiloride, a potassium-sparing diuretic, blocks the epithelial sodium channels in the collecting duct, preventing sodium reabsorption while allowing potassium excretion. This combination helps maintain fluid balance and prevents the loss of potassium often associated with thiazide diuretics, thereby reducing the risk of hypokalemia.

Hydrochlorothiazide 12.5mg, Amiloride

Thiazide diuretic, potassium-sparing diuretic.

Tablet

The following are the uses of Hydrochlorothiazide 12.5mg, Amiloride Tablet:

• Used for treating high blood pressure, helping to lower and control hypertension.
• Used for managing fluid retention (edema), reducing excess fluid in the body.
• Used for treating heart failure, aiding in symptom management and fluid regulation.
• Used for preventing kidney stones, particularly calcium-based stones, by regulating urine chemistry.
• Used for managing diabetes insipidus, a condition affecting water balance.
• Used for supporting overall cardiovascular health and reducing the risk of heart-related complications.
• Used for alleviating symptoms of edema caused by various medical conditions.

In the case of an overdose of Hydrochlorothiazide 12.5mg and Amiloride Tablets, individuals may experience symptoms such as dizziness, low blood pressure, and electrolyte imbalances. The severity of the effects can vary depending on the individual's health and the amount ingested. Prompt medical intervention is necessary to manage the symptoms and prevent potential complications. It is important to seek medical advice and follow the recommended dosage to ensure safe usage of these medications.

In the case of a missed dose of Hydrochlorothiazide 12.5mg, it is generally recommended to take the missed dose as soon as you remember, unless it is close to the time for your next scheduled dose. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. However, if you miss a dose of Amiloride Tablet, take it as soon as possible and then adjust the timing of your next dose accordingly, ensuring you still complete the full course of medication as prescribed by your healthcare provider.

To take Hydrochlorothiazide 12.5mg and Amiloride Tablet, swallow the tablet whole with a glass of water, ensuring you follow the prescribed dosage instructions provided by your healthcare provider.

Following are the conditions or situations when Hydrochlorothiazide 12.5mg and Amiloride Tablet should not be used:

• Should not be used in patients with a known allergy to Hydrochlorothiazide, Amiloride, or any of the sulfonamide-derived medications.
• Contraindicated in patients with severe kidney disease or those who are unable to urinate.
• Not recommended for individuals with significantly low potassium or sodium levels in the blood.
• Should not be used if you have diabetic kidney disease or diabetic nephropathy.
• Contraindicated during pregnancy, especially in the second and third trimesters.
• Should be avoided if you have severe liver disease or progressive liver disease.
• Not suitable for individuals with Addison's disease (adrenal gland disorder).

The side effects of Hydrochlorothiazide 12.5mg and Amiloride Tablet may include:

• Increased sensitivity to sunlight
• Dizziness or lightheadedness
• Headache
• Nausea and vomiting
• Diarrhea
• Muscle cramps or weakness
• Skin rash or itching
• Fatigue or tiredness

Following are the precautions and warnings for Hydrochlorothiazide 12.5mg, Amiloride Tablet:

• Patients with a known allergy to either Hydrochlorothiazide or Amiloride should not take this medication.
• Regular monitoring of kidney function is necessary, especially in patients with pre-existing kidney problems, as the medication can affect renal function.
• Electrolyte levels, particularly potassium, should be monitored regularly due to the potential for electrolyte imbalances.
• This medication may cause an increased sensitivity to sunlight; therefore, it is advised to limit sun exposure and use protective measures when outdoors.
• Patients with diabetes should be cautious as this medication can affect blood sugar levels.
• Those with a history of liver problems should exercise caution and inform their healthcare provider, as the medication can impact liver function.
• It is important to maintain adequate hydration while taking this medication to prevent dehydration and related complications.
• Patients should inform their doctor about any other medications they are taking to avoid potential drug interactions.

Following are the drug interactions for Hydrochlorothiazide 12.5mg and Amiloride Tablet:

• Hydrochlorothiazide may reduce the elimination of lithium, leading to increased lithium levels and potential toxicity. Close monitoring of lithium levels is necessary.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can decrease the blood pressure-lowering effect of Hydrochlorothiazide and may increase the risk of kidney function impairment.
• Combining Hydrochlorothiazide with other medications that lower blood pressure, such as ACE inhibitors or beta-blockers, can result in excessive blood pressure drop.
• Amiloride may interact with potassium-sparing diuretics, leading to increased potassium levels in the body.
• High-potassium foods and potassium supplements should be used with caution, as Amiloride can also raise potassium levels.
• The effectiveness of Amiloride may be reduced by laxatives or corticosteroids.
• It is important to monitor potassium levels when Amiloride is used with angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs).

Following are the food interactions for Hydrochlorothiazide 12.5mg and Amiloride Tablet:

• Avoid excessive salt or sodium intake, as both medications can interact with high sodium levels, potentially leading to increased blood pressure and reduced drug effectiveness.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed moderately, as Amiloride can increase potassium levels, and excessive intake may lead to hyperkalemia.
• Limit alcohol consumption as it can further lower blood pressure, causing dizziness and lightheadedness, especially with Hydrochlorothiazide.
• Grapefruit and grapefruit juice should be avoided or consumed minimally, as they may interfere with the metabolism of these medications, potentially increasing their blood levels and the risk of side effects.
• Maintain a balanced diet; excessive or inadequate fluid intake can affect blood pressure and electrolyte balance, which these medications aim to regulate.
• Avoid potassium supplements unless prescribed, as Amiloride can affect potassium levels, and additional supplementation may lead to an imbalance.
• Inform your healthcare provider about any herbal supplements or natural remedies you use, as some may interact with these medications, particularly those affecting blood pressure and kidney function.

Hydrochlorothiazide 12.5mg and Amiloride Tablets should be stored in a secure, dry location at room temperature, ideally between 68°F and 77°F (20°C and 25°C). Ensure you keep the tablets in their original container, tightly sealed, to protect them from moisture and light. It's crucial to maintain a consistent temperature, avoiding exposure to excessive heat or cold, as this can impact the medication's effectiveness. Never store the tablets in the bathroom medicine cabinet due to its humidity. Always check the expiration date, and if the medication is past its prime or no longer needed, dispose of it carefully. Consult your pharmacist or local waste disposal company for guidance on proper disposal methods, as flushing or pouring it down the drain can harm the environment. Keep the medication out of children's reach to prevent accidental ingestion.

Following are the quick tips for Hydrochlorothiazide 12.5mg and Amiloride Tablet:

• Always take the medication as directed by your doctor.
• Maintain a consistent daily routine for taking the tablets.
• Ensure you swallow the tablets whole with a glass of water.
• Avoid cutting, crushing, or chewing the tablets.
• If you forget a dose, take it as soon as you remember, unless it's almost time for your next dose.
• Do not double the dose to make up for a missed one.
• Store the medication in a cool, dry place, away from direct sunlight.