Mac-Fenid 267mg

Pirfenidone 267mg Tablet's primary mechanism of action involves reducing fibrosis and inflammation in the body. It achieves this by downregulating the production of transforming growth factor-beta (TGF-β), a key cytokine involved in the fibrotic process. Pirfenidone inhibits the TGF-β pathway, leading to decreased collagen production and deposition, which are hallmarks of fibrotic diseases. Additionally, it exerts anti-inflammatory effects by modulating the immune response, including the reduction of pro-inflammatory cytokines and the inhibition of certain immune cell functions. This dual action helps in slowing down the progression of fibrosis and improving symptoms associated with fibrotic conditions.

Antifibrotic

Tablet

The following are the uses of Pirfenidone 267mg Tablet:

• Used for treating idiopathic pulmonary fibrosis, a lung disease where the lungs become scarred and stiff.
• Used to slow down the progression of lung function decline and improve breathing capacity.
• Used to manage symptoms and improve quality of life in patients with this chronic lung condition.
• Used to reduce inflammation and fibrosis in the lungs, helping to preserve lung function.
• Used as a long-term treatment option to delay the need for lung transplantation.
• Used for its anti-fibrotic properties to prevent further scarring and damage to lung tissue.

In the case of an overdose of Pirfenidone 267mg Tablets, it is important to recognize the potential symptoms and take appropriate action. Overdose symptoms may include nausea, vomiting, diarrhea, and dizziness. If you suspect an overdose, seek medical advice immediately. Contact a healthcare professional or a poison control center for guidance on managing the overdose, as they can provide specific instructions based on the individual's condition. Timely intervention can help mitigate the effects of an overdose.

In the case of a missed dose of Pirfenidone 267mg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to adjust your dosing schedule and ensure you're taking the medication as effectively as possible.

To take Pirfenidone 267mg Tablet, swallow the tablet whole with a glass of water, preferably with food, following the dosage instructions provided by your healthcare professional, typically three times a day, approximately every 6 to 8 hours.

Here are the situations when Pirfenidone 267mg Tablet should not be used:

• Should not be taken by individuals who are allergic to Pirfenidone or any of its ingredients.
• Contraindicated in patients with severe liver impairment.
• Not recommended for individuals with severe renal (kidney) impairment.
• Avoid using if you have a history of severe skin reactions to medications.
• Do not take this medication if you are pregnant or planning to become pregnant, as it may cause harm to the fetus.
• Should not be used by breastfeeding mothers due to potential risks to the infant.
• Not suitable for children and adolescents under 18 years of age.
• Avoid if you have a history of gastrointestinal disorders or recent gastrointestinal surgery, as it may worsen these conditions.

The side effects of Pirfenidone 267mg Tablet may include:

• Nausea and vomiting
• Loss of appetite
• Weight loss
• Diarrhea
• Dizziness
• Skin rashes or itching
• Photosensitivity (sensitivity to sunlight)
• Fatigue and weakness

Following are the precautions and warnings for Pirfenidone 267mg Tablet:

• Not recommended for individuals with known hypersensitivity or severe allergic reactions to Pirfenidone or any of its excipients.
• Regular monitoring of liver function tests is necessary during treatment, and if significant liver enzyme elevations occur, the drug should be discontinued.
• May cause photosensitivity, so patients should be advised to use sunscreen and protective clothing when exposed to sunlight.
• Patients with severe renal impairment should be closely monitored, and dosage adjustments might be required.
• This medication may cause dizziness and fatigue, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Pirfenidone should be used with caution in patients with a history of gastrointestinal disorders, as it may cause nausea, vomiting, and gastrointestinal bleeding.
• Not recommended for use in pregnant or breastfeeding women unless the potential benefits outweigh the risks.

Following are the drug interactions for Pirfenidone 267mg Tablet:

• Concomitant use with strong CYP1A2 inhibitors like fluvoxamine can increase Pirfenidone levels, potentially leading to increased side effects.
• Rifampin, a strong CYP1A2 inducer, may decrease the effectiveness of Pirfenidone by reducing its blood levels.
• The effectiveness of Pirfenidone may be reduced when used with strong CYP2C19 inducers such as rifampin.
• Grapefruit juice should be avoided as it can inhibit CYP1A2 and increase Pirfenidone levels.
• Antacids containing aluminum hydroxide may decrease the absorption of Pirfenidone, so separate administration by at least 1 hour.
• Avoid combining with drugs that prolong the QT interval, as Pirfenidone may also prolong QT interval.
• Caution is advised when using Pirfenidone with photosensitizing drugs, as it may increase sensitivity to sunlight.

Following are the food interactions for Pirfenidone 267mg Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can increase the drug's concentration in the body, potentially causing adverse effects.
• Alcohol intake is not recommended as it may increase the risk of liver-related side effects and negatively impact the medication's effectiveness.
• Avoid high-fat meals as they can increase the absorption of Pirfenidone, leading to higher blood levels and potential side effects.
• Caffeine intake should be limited as it may interfere with the medication's metabolism, affecting its therapeutic effects.
• Avoid excessive salt intake, as Pirfenidone may interact with a high-sodium diet, impacting blood pressure regulation.
• Consuming foods rich in Vitamin D and calcium is advisable as Pirfenidone may affect bone mineralization.
• Ensure adequate hydration by drinking plenty of fluids to reduce the risk of gastrointestinal side effects.
• Certain herbal supplements like St. John's Wort may affect the metabolism of Pirfenidone, so consult your doctor before taking any herbal remedies.

Pirfenidone 267mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight, moisture, and heat. It is crucial to keep the medication in its original packaging, ensuring the container is tightly sealed to maintain its integrity. Do not expose the tablets to extreme temperatures, as it may impact their effectiveness. Regularly check the expiration date, and if the medication is past its expiry, do not use it and dispose of it appropriately. When disposing of unused or expired tablets, do not flush them or throw them into the trash; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Remember to keep all medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Pirfenidone 267mg Tablet:

• Take the tablet as directed by your doctor, typically 3 times a day.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Consume the tablet with or after food to minimize gastrointestinal side effects.
• Maintain a consistent daily routine for taking the medication.
• Avoid missing doses; if you miss a dose, take it as soon as you remember, unless it's close to the next dose.
• Do not double the dose to make up for a missed one; resume your regular schedule.
• Regularly monitor your liver function and inform your doctor of any unusual symptoms.