Mac-Fer Sachets

Ferric Carboxymaltose is a complex of iron (Fe3+) and carboxymaltose, designed to replenish iron stores in the body. Its mechanism of action primarily involves the replenishment of iron, which is essential for various physiological processes. Upon administration, Ferric Carboxymaltose is rapidly absorbed and binds to transferrin, a protein responsible for transporting iron in the bloodstream. The iron-transferrin complex is then taken up by cells, particularly erythroid precursor cells in the bone marrow, where it is utilized for hemoglobin synthesis. This process enhances the production of red blood cells, thereby increasing the oxygen-carrying capacity of the blood. The iron also supports the proper functioning of enzymes involved in energy metabolism, DNA synthesis, and various cellular processes, contributing to overall cellular health and function.

Iron, Ferric Carboxymaltose

Intravenous iron complex

Injection

The following are the uses of Iron, Ferric Carboxymaltose Sachet:

• Used for treating Iron Deficiency Anaemia
• Used to replenish iron levels in the body
• Used for improving red blood cell production
• Used in cases of chronic kidney disease to manage anaemia
• Used during pregnancy to address iron deficiencies
• Used to enhance energy levels and reduce fatigue
• Used for maintaining overall health and well-being in individuals with iron deficiencies
• Used to support the body's natural healing processes

In the case of an overdose of Iron, Ferric Carboxymaltose Sachet, symptoms may include gastrointestinal issues such as nausea, vomiting, and diarrhea. More severe cases can lead to circulatory shock, liver damage, and even death. Prompt medical intervention is necessary, including monitoring vital signs, ensuring airway patency, and potentially administering intravenous fluids and supportive care. It is crucial to seek immediate medical assistance and provide healthcare professionals with the necessary information regarding the overdose.

In the case of a missed dose of Iron, Ferric Carboxymaltose Sachet, it is important to consult your healthcare provider for guidance. They will advise you on whether to take the missed dose as soon as you remember or to skip it entirely and resume your regular dosing schedule. Do not take a double dose to make up for a missed one unless instructed by your doctor. If you frequently miss doses, inform your healthcare provider, as they may need to adjust your treatment plan.

To administer Ferric Carboxymaltose Sachet, mix the entire contents of the sachet with water or fruit juice, stir well until dissolved, and consume the entire mixture orally, following the prescribed dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Iron, Ferric Carboxymaltose Sachet should not be used:

• Not recommended for individuals with a known hypersensitivity or allergy to ferric carboxymaltose or any of its excipients.
• Should not be administered to patients with iron overload syndromes, such as hemochromatosis or hematological disorders like thalassemia or sickle cell disease.
• Contraindicated in patients with anemia not caused by iron deficiency, as it may exacerbate underlying conditions.
• Not suitable for individuals with acute or chronic bleeding disorders until the bleeding is controlled, as iron therapy may not be effective.
• Should be avoided in patients with a history of anaphylactic/anaphylactoid reactions, especially to parenteral iron products.
• Not recommended for use in patients with severe kidney disease or those on dialysis, as it may lead to iron accumulation.
• Contraindicated in patients with a history of multiple blood transfusions, as iron stores may already be high.

The side effects of Iron, Ferric Carboxymaltose Sachet may include:

• Nausea and vomiting
• Diarrhea or constipation
• Abdominal pain or cramps
• Darkened stools
• Temporary staining of teeth (when mixed with water and consumed)
• Skin discoloration at the injection site (if administered intravenously)
• Dizziness or lightheadedness
• Headache

Following are the precautions and warnings for Iron, Ferric Carboxymaltose Sachet:

• This medication should not be used in individuals with a known allergy to ferric carboxymaltose or any of its excipients.
• Patients with a history of gastrointestinal disorders, such as inflammatory bowel disease or ulcers, should use it with caution as it may worsen these conditions.
• It may cause constipation, so patients with a history of bowel obstruction or gastrointestinal motility disorders should be monitored closely.
• Dehydration or inadequate fluid intake may increase the risk of side effects; ensure adequate hydration during treatment.
• It may interfere with certain laboratory tests, so inform your healthcare provider if you are scheduled for any blood tests.
• Patients with a history of multiple blood transfusions or receiving intravenous iron therapy for the first time should be closely monitored for potential allergic reactions.
• Pregnant and breastfeeding women should only use this medication under medical supervision, as iron requirements may vary during these periods.

Following are the drug interactions for Iron, Ferric Carboxymaltose Sachet:

• Iron may reduce the absorption of other medications like Tetracyclines, Bisphosphonates, Levodopa, and Quinolones, so separate administration by 2-3 hours.
• Antacids containing calcium, magnesium, or aluminum can decrease iron absorption, so take at different times.
• Iron can decrease the effectiveness of Levothyroxine, so separate administration by 2-4 hours.
• Iron may decrease the absorption of certain antibiotics like Ciprofloxacin and Doxycycline.
• Theophylline levels may increase with iron supplementation, requiring monitoring.
• Iron can reduce the efficacy of vaccines containing live attenuated organisms, so separate administration by 2-4 weeks.
• Iron can decrease the absorption of Zinc, so take them at different times.

Following are the food interactions for Iron, Ferric Carboxymaltose Sachet:

• Iron absorption can be enhanced by consuming vitamin C-rich foods like citrus fruits, strawberries, and bell peppers alongside the sachet.
• Dairy products such as milk, cheese, and yogurt can inhibit iron absorption and should be consumed separately.
• Coffee and tea contain polyphenols that can reduce iron absorption, so avoid drinking them with or immediately after taking the sachet.
• Whole grain products and high-fiber foods may decrease iron absorption, so it's best to take the sachet on an empty stomach.
• Foods rich in calcium, like dairy and calcium-fortified juices, can interfere with iron absorption and should be consumed at different times.
• Eggs, especially the yolks, contain phosvitin, which can bind to iron and reduce its absorption. Avoid eating eggs close to the time of taking the sachet.
• Soy protein and its derivatives may decrease iron absorption, so consider separating soy-based foods from your iron supplementation.
• Certain plant-based foods like spinach and beans contain oxalates and phytates, which can hinder iron absorption. Cook these foods thoroughly to reduce these compounds.

Iron, Ferric Carboxymaltose Sachet should be stored in a cool and dry environment, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the sachets inside their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Avoid placing them in the bathroom or near heat-emitting appliances to prevent temperature fluctuations that could impact the medication's quality. Dispose of any unused or expired sachets responsibly; do not flush them down the toilet or pour them into drainage systems. Consult your pharmacist or healthcare provider for appropriate disposal methods. Keep this medication away from children to prevent accidental ingestion.

Following are the quick tips for Iron, Ferric Carboxymaltose Sachet:

• Consult a healthcare professional for dosage instructions based on your iron deficiency severity.
• Dissolve the sachet contents in water or juice as directed; do not swallow the powder directly.
• Ensure complete dissolution before consumption for optimal absorption.
• Consume the solution immediately after preparation for best results.
• Avoid taking antacids or calcium supplements within 2 hours of iron intake.
• Store sachets in a cool, dry place, away from direct sunlight.
• Do not share your medication with others, even if they have similar symptoms.