Macnaz (20mg/ml) 20ml Oral Drops

Miconazole, the active ingredient in Miconazole Drops, primarily exerts its antifungal action by disrupting the integrity of the fungal cell membrane. It selectively binds to a specific enzyme called lanosterol 14α-demethylase, which plays a critical role in the biosynthesis of ergosterol, a major component of fungal cell membranes. By inhibiting this enzyme, miconazole prevents the formation of ergosterol, leading to the accumulation of toxic byproducts within the fungal cell. This disruption in ergosterol synthesis weakens the fungal cell membrane, causing its structure and function to deteriorate, ultimately resulting in fungal cell death. This mechanism effectively targets fungi while minimizing harm to human cells, as human cell membranes contain cholesterol instead of ergosterol.

Antifungal.

Drop

The following are the uses of Miconazole Drop:

• Used for treating fungal infections, particularly those affecting the skin and nails.
• Used for relieving itching, redness, and discomfort caused by fungal growth.
• Used for managing athlete's foot, ringworm, and jock itch.
• Used for preventing the spread of fungal infections to other body parts.
• Used for maintaining skin health and restoring its normal appearance.
• Used for providing targeted treatment directly to the affected areas.
• Used for preventing fungal infections in high-risk individuals.
• Used for complementing other antifungal treatments as directed by a healthcare professional.

In the case of an overdose of Miconazole Drops, it is important to remain calm and seek medical advice promptly. Overuse may lead to an increased risk of adverse effects, particularly in sensitive individuals. Symptoms such as skin irritation, redness, or a burning sensation may occur at the application site. It is advisable to contact a healthcare professional for guidance on managing any potential side effects and to ensure appropriate treatment.

In the case of a missed dose of Miconazole Drops, it is important to administer the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. However, if you miss multiple doses or are unsure about how to proceed, contact your healthcare provider for guidance on how to adjust your dosing schedule. It is best to consult a medical professional for advice on managing missed doses.

To use Miconazole Drops, tilt your head back, gently pull down the lower eyelid to create a pocket, and hold the dropper directly over the eye, dispensing the prescribed number of drops into the lower eyelid pocket, then gently close the eye and blink to ensure even distribution.

Following are the conditions when Miconazole Drops should not be used:

• Do not use if you have a known allergy or sensitivity to Miconazole or any other antifungal medications.
• Avoid using Miconazole drops if you have a perforated eardrum or a history of ear surgery.
• Not recommended for individuals with ongoing or severe ear infections; consult a doctor for alternative treatments.
• Do not use if you have a history of hypersensitivity reactions to similar medications.
• Should not be used if the solution is discolored or contains particles.
• Contraindicated for individuals with a history of hearing loss or severe ear pain.
• Not suitable for children without medical advice and supervision.
• Do not use if you have any other ear conditions or disorders without medical consultation.
• Avoid using if you have a history of skin reactions or irritation after using similar ear drops.

The side effects of Miconazole Drop may include:

• Skin irritation or redness at the application site
• Burning or stinging sensation
• Itching or rash
• Swelling or inflammation
• Dryness of the skin or mucous membranes
• Allergic reactions (such as hives, difficulty breathing, swelling of the face/lips/tongue)
• Headache
• Nausea or upset stomach

Following are the precautions and warnings for Miconazole Drops:

• Avoid contact with eyes and mucous membranes. In case of accidental contact, rinse thoroughly with water.
• This medication is for external use only. Do not swallow or ingest.
• Wash your hands before and after applying the drops to prevent contamination and the spread of infection.
• Do not use the drops if the solution appears cloudy or discolored, as this may indicate contamination.
• Discontinue use and consult a healthcare professional if irritation, redness, or swelling persists or worsens.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.
• Do not share the medication with others, even if they have similar symptoms, as it may not be suitable for everyone.

Following are the drug interactions for Miconazole Drop:

• Miconazole can increase the effects of certain blood thinners (e.g., warfarin), potentially causing bleeding issues.
• It may interact with oral antidiabetic drugs, leading to low blood sugar levels.
• Miconazole can reduce the effectiveness of oral contraceptives, potentially causing breakthrough bleeding.
• Co-administration with H2-receptor antagonists (e.g., cimetidine) may result in increased plasma concentrations of miconazole.
• The drop may interact with certain HIV protease inhibitors, affecting the levels of both drugs.
• It can increase the plasma concentrations of statins, potentially increasing the risk of statin-related adverse effects.
• Miconazole can also interact with certain antiarrhythmic drugs, affecting the heart's electrical activity.

Following are the food interactions to be aware of when using Miconazole Drops:

• Avoid consuming grapefruit and grapefruit juice as they can increase the concentration of Miconazole in the body, potentially leading to increased side effects.
• Alcohol consumption should be minimized or avoided as it may increase the risk of liver-related side effects.
• Certain foods rich in vitamin E, such as nuts, seeds, and vegetable oils, may interfere with Miconazole's effectiveness.
• Fatty or greasy foods may affect the absorption of Miconazole, so it's best to avoid them around the time of drop administration.
• Avoid spicy foods as they may cause irritation and discomfort, especially if you have oral or throat infections.
• Dairy products like milk and cheese can potentially interact with Miconazole, reducing its effectiveness.
• Sugary foods and beverages should be limited as they can promote the growth of Candida, the fungus that Miconazole is designed to treat.
• Always consult your healthcare provider for personalized advice regarding food and medication interactions.

Miconazole Drops require specific storage and disposal considerations to maintain their effectiveness and ensure safety. Store the drops in a cool and dry place, preferably at room temperature, away from direct sunlight and moisture exposure. Keep the medication securely sealed in its original container to maintain sterility and prevent contamination. Avoid storing it in humid areas like bathrooms or near heat sources, as temperature fluctuations can impact its quality. Regularly check the expiration date, and dispose of any unused or expired drops promptly. Do not dispose of the medication by flushing or pouring it down the drain; instead, consult a pharmacist or healthcare professional for appropriate disposal methods to protect the environment. Keep the medication out of children's reach to prevent accidental ingestion.

Following are the quick tips for Miconazole Drops:

• Wash your hands thoroughly before and after applying the drops to maintain hygiene.
• Clean the affected ear gently and ensure it is dry before administering the drops.
• Tilt your head to the side and gently pull the ear lobe back to straighten the ear canal.
• Place the prescribed number of drops into the ear, then gently massage the outer ear to help distribute the medication.
• Avoid touching the dropper tip to prevent contamination.
• Do not insert any objects into the ear to clean it during treatment.
• Complete the full course of treatment as prescribed by your doctor for maximum effectiveness.