Maggesic Tab 100's

Orphenadrine, the active ingredient in Orphenadrine Tablets, primarily exerts its therapeutic effects through its action as an anticholinergic agent and a muscle relaxant. It competitively inhibits acetylcholine at various cholinergic receptor sites in the central and peripheral nervous systems, particularly at the neuromuscular junction. By blocking these receptors, orphenadrine reduces muscle spasms and relaxes skeletal muscles. Additionally, orphenadrine exhibits mild local anesthetic properties, which may contribute to its analgesic effects. The drug's mechanism of action helps alleviate pain, stiffness, and discomfort associated with muscle spasms, making it useful in the management of various musculoskeletal conditions.

Anticholinergic/antispasmodic.

Tablet

The following are the uses of Orphenadrine Tablet:

• Used for relieving pain and reducing muscle spasms, especially in the back or neck.
• Used for treating muscle injuries and certain types of arthritis.
• Used to provide muscle relaxation and ease stiffness.
• Used for managing symptoms of Parkinson's disease, aiding in movement control.
• Used for treating severe muscle pain and stiffness associated with various conditions.
• Used to improve mobility and reduce discomfort in affected muscles.
• Used for managing side effects of certain medications, such as muscle rigidity.

In the case of an overdose of Orphenadrine Tablets, it is important to act promptly. Symptoms may include severe dry mouth, confusion, blurred vision, and difficulty urinating. If you suspect an overdose, contact a healthcare professional immediately. Quick action is crucial, as prompt medical intervention can help manage symptoms and prevent potential complications. It is essential to provide accurate information about the medication and dosage to ensure effective treatment.

In the case of a missed dose of Orphenadrine Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Avoid doubling the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication routine. Always consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take Orphenadrine Tablets, swallow the tablet whole with a full glass of water, following the prescribed dosage instructions provided by your healthcare professional, typically taken 3 to 4 times a day, and it is important to maintain consistency in timing between doses.

Here are the conditions or situations when Orphenadrine Tablet should not be taken:

• Avoid using if you have a known allergy or hypersensitivity to Orphenadrine, other anticholinergic drugs, or any of the tablet's components.
• Not recommended for patients with narrow-angle glaucoma.
• Contraindicated in individuals with a history of urinary retention.
• Should not be used in patients with severe heart failure or cardiovascular disease.
• Avoid using if you have a blockage in your intestines or difficulty passing urine.
• Not suitable for individuals with severe liver or kidney disease.
• Do not use in patients with myasthenia gravis or severe ulcerative colitis.
• Contraindicated during pregnancy and breastfeeding.
• Should not be given to children under 12 years of age.

The side effects of Orphenadrine Tablet may include:

• Dry mouth
• Dizziness
• Constipation
• Nausea and vomiting
• Blurred vision
• Confusion
• Rapid heartbeat
• Difficulty in urination

Following are the precautions and warnings for Orphenadrine Tablet:

• Do not use if you are allergic to Orphenadrine or any other anticholinergic drugs.
• This medication may cause drowsiness or dizziness, so caution is advised against driving or operating heavy machinery until you know how the medication affects you.
• Alcohol consumption should be avoided as it can increase the risk of side effects.
• Orphenadrine should be used with caution in patients with a history of liver or kidney disease, as it may require dosage adjustments.
• Not recommended for use in children under 12 years old.
• Elderly patients may be more sensitive to the side effects, so dosage adjustments may be necessary.
• Consult your doctor if you have a history of glaucoma, urinary retention, or gastrointestinal obstruction as Orphenadrine may worsen these conditions.

Following are the drug interactions for Orphenadrine Tablet:

• It should not be combined with other anticholinergic drugs, as it may lead to increased side effects such as dry mouth, blurred vision, and urinary retention.
• Alcohol and Orphenadrine can cause additive CNS depression, leading to sedation and impaired motor skills.
• Monoamine oxidase inhibitors (MAOIs) should not be taken concurrently due to the risk of severe adverse reactions.
• Concomitant use with other central nervous system (CNS) depressants like opioids or benzodiazepines can enhance respiratory depression.
• Orphenadrine may increase the effects of antihypertensive medications, causing excessive hypotension.
• It can interact with anticholinesterase medications, potentially resulting in muscle weakness and respiratory problems.
• Certain antidepressants, especially tricyclic antidepressants, may have additive anticholinergic effects when used with Orphenadrine.

Following are the food interactions for Orphenadrine Tablet:

• Alcohol consumption should be avoided as it can increase the risk of side effects, particularly dizziness and drowsiness, due to its central nervous system depressant effects.
• Grapefruit and grapefruit juice are to be avoided as they can interfere with the metabolism of Orphenadrine, leading to increased drug levels in the body and potentially causing adverse reactions.
• Caffeine intake should be limited as Orphenadrine may enhance its effects, resulting in increased heart rate and blood pressure.
• High-fat meals can slow down the absorption of Orphenadrine, potentially reducing its effectiveness, so it's best to take the medication on an empty stomach.
• Avoid eating large amounts of chocolate as it contains caffeine and theobromine, which can interact with Orphenadrine and affect heart rate and blood pressure.
• Some herbal supplements, like St. John's Wort, may decrease Orphenadrine levels by inducing its metabolism, reducing its therapeutic effect.
• Avoid aged cheeses and processed meats as they can contain high levels of tyramine, which may interact with Orphenadrine and lead to a dangerous spike in blood pressure.
• Always inform your healthcare provider about your diet and any herbal supplements you take to ensure safe and effective use of Orphenadrine.

Orphenadrine tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, ensuring they are out of reach of children and pets. Maintain a consistent room temperature, avoiding exposure to excessive heat, moisture, or direct sunlight, as these conditions can degrade the medication. Always keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial to dispose of unused or expired tablets responsibly; do not flush them down the toilet or throw them into the trash. Instead, consult your pharmacist or healthcare provider for guidance on proper disposal methods to minimize environmental impact. Regularly check the expiration date, and replace any expired medication as necessary.

Following are the quick tips for Orphenadrine Tablet:

• Take the tablet as directed by your doctor, typically 2 to 4 times a day.
• Swallow the tablet whole with a full glass of water; do not crush or chew.
• You can take it with or without food, but taking it with food may prevent stomach upset.
• Maintain a consistent schedule for taking the medication to ensure steady blood levels.
• Do not drive or operate machinery until you know how this medicine affects you.
• Inform your doctor about all the medications you are taking to avoid potential interactions.
• Store the tablets at room temperature, away from moisture and light.