MAGNOPYROL INJ

Metamizole Magnesium, commonly known as dipyrone, exerts its analgesic, antipyretic, and anti-inflammatory effects through multiple mechanisms. It primarily acts as a non-selective inhibitor of cyclooxygenase (COX), thereby reducing the synthesis of prostaglandins, which are key mediators of pain, inflammation, and fever. Additionally, metamizole has been shown to inhibit the enzyme lipoxygenase, further contributing to its anti-inflammatory properties. It also modulates nociception by interacting with serotonin and histamine receptors, and may influence the gamma-aminobutyric acid (GABA) system, which plays a role in pain perception and transmission. These diverse actions collectively contribute to the analgesic and antipyretic effects observed with metamizole magnesium injection.

Non-steroidal anti-inflammatory drug (NSAID)

Injection

The following are the uses of Metamizole Magnesium Injection:

• Used for relieving moderate to severe pain, such as post-operative pain, traumatic pain, and pain associated with cancer.
• Used for reducing fever and treating high body temperatures.
• Used for managing pain and discomfort during childbirth.
• Used for alleviating pain and inflammation in conditions like arthritis and gout.
• Used for providing short-term pain relief in emergency situations.
• Used for treating acute migraine attacks and severe headaches.
• Used for managing pain and inflammation after dental procedures.

In the case of an overdose of Metamizole Magnesium Injection, symptoms may include severe drowsiness, nausea, vomiting, and in extreme cases, respiratory depression or seizures. The severity of symptoms depends on the amount ingested and individual sensitivity. Prompt medical intervention is necessary, including gastric lavage and supportive care to manage respiratory and cardiovascular functions. Timely treatment can help mitigate the potentially serious consequences of an overdose.

In the case of a missed dose of Metamizole Magnesium Injection, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, it is recommended to skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, it is advisable to set reminders or use a medication tracking app to help you stay on track with your treatment plan. Consult your healthcare provider if you have any concerns or questions about managing missed doses.

To administer the Metamizole Magnesium Injection, clean the injection site, insert the needle at a 90-degree angle, and slowly inject the prescribed dose, ensuring the entire medication is delivered, then safely dispose of the needle and syringe after use.

Following are the conditions/situations when Metamizole Magnesium Injection should not be used:

• Must not be used in individuals with a known allergy or hypersensitivity to Metamizole Magnesium or other pyrazolone derivatives.
• Contraindicated in patients with a history of agranulocytosis or severe blood disorders caused by Metamizole Magnesium or similar drugs.
• Should not be administered to patients with bone marrow depression or pre-existing blood disorders.
• Not suitable for individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Contraindicated in patients with acute porphyria, as it may trigger a porphyria attack.
• Should not be used in patients with severe heart, liver, or kidney disease.
• Must not be administered to patients with active peptic ulcers or gastrointestinal bleeding.
• Not recommended for individuals with asthma or a history of bronchospasm.
• Contraindicated in patients with a history of chronic headache or medication-induced headache.

The side effects of Metamizole Magnesium Injection may include:

• Skin rashes or itching
• Allergic reactions
• Nausea and vomiting
• Dizziness or lightheadedness
• Headache
• Palpitations
• Temporary suppression of bone marrow function
• Agranulocytosis (a severe decrease in white blood cells)

Following are the precautions and warnings:

• Metamizole Magnesium Injection should not be administered to patients with known hypersensitivity or allergy to pyrazolone derivatives or any of its components.
• This medication is contraindicated in patients with a history of agranulocytosis or bone marrow depression caused by Metamizole.
• Caution is advised in patients with kidney or liver impairment, as dosage adjustments may be necessary.
• Metamizole should be used with caution in individuals with asthma, as it may trigger bronchospasm.
• It should not be used during the first and last trimesters of pregnancy and breastfeeding unless the potential benefits outweigh the risks.
• Avoid alcohol consumption while using Metamizole Magnesium as it may increase the risk of gastrointestinal bleeding.
• Patients with pre-existing cardiovascular conditions should be closely monitored as it may cause hypotension.

Following are the drug interactions for Metamizole Magnesium Injection:

• Alcohol and other central nervous system depressants may enhance the sedative effects of Metamizole, leading to increased drowsiness and impaired breathing.
• Anticoagulants like warfarin can have their effects potentiated, increasing the risk of bleeding.
• Barbiturates can decrease the analgesic effect of Metamizole and increase the risk of liver damage.
• Concomitant use with other non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal bleeding and kidney problems.
• Corticosteroids may increase the risk of gastrointestinal bleeding when taken with Metamizole.
• Some antidepressants (e.g., selective serotonin reuptake inhibitors) may increase the risk of bleeding when combined with Metamizole.
• Caution is advised when using Metamizole with other drugs that are metabolized by the liver, as it may affect their metabolism and increase side effects.

Following are the food interactions for Metamizole Magnesium Injection:

• Avoid alcohol consumption during the treatment period as it can increase the risk of gastrointestinal bleeding and liver toxicity.
• Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the metabolism of Metamizole, potentially leading to increased blood levels and a higher risk of adverse effects.
• Avoid caffeine-rich foods and beverages like coffee, tea, and energy drinks as they can enhance the stimulant effects of Metamizole, causing restlessness and sleep disturbances.
• Consuming high-fat meals may delay the absorption of Metamizole, potentially affecting the onset of its pain-relieving action.
• Avoid spicy foods as they can irritate the gastrointestinal tract, especially if Metamizole is causing stomach discomfort as a side effect.
• Avoid foods and beverages with high sugar content as they can interact with the Magnesium component, affecting its absorption and potentially leading to imbalances.
• There is no specific diet recommendation, but maintaining a balanced diet is advisable to support overall health during the treatment process.
• Always consult your healthcare provider for personalized advice regarding dietary restrictions or modifications.

Metamizole Magnesium Injection should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and moisture. It is crucial to maintain a temperature range between 15°C and 25°C (59°F and 77°F) to ensure the stability of the injection. The medication should be kept in its original packaging, tightly sealed, to prevent contamination and maintain its integrity. Do not freeze the injection as it may affect its potency. Always check the expiration date before use, and discard any unused or expired medication responsibly. For proper disposal, consult your pharmacist or healthcare provider for guidance, and avoid flushing or pouring it down the drain. Keep the injection out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Metamizole Magnesium Injection:

• Administer the injection under medical supervision for pain relief and fever reduction.
• Ensure the injection is given into a muscle or vein as directed by a healthcare professional.
• Avoid using alcohol or other sedatives during treatment without medical advice.
• Inform your doctor if you have kidney or liver problems before taking this medication.
• Do not drive or operate machinery if you experience dizziness or drowsiness after the injection.
• Store the injection at room temperature, away from direct sunlight and moisture.
• Discontinue use and seek medical attention if you notice any allergic reactions or severe skin rashes.