MAGNOPYROL TAB DS

Metamizole Magnesium Tablet primarily exerts its analgesic, antipyretic, and anti-inflammatory effects through multiple mechanisms of action. It acts as a non-selective inhibitor of cyclooxygenase (COX), an enzyme responsible for prostaglandin synthesis, thus reducing the production of prostaglandins involved in pain and inflammation. Additionally, metamizole may interact with the body's opioid systems, possibly by enhancing the release of endogenous opioids, which contributes to its pain-relieving properties. It is also believed to possess central nervous system effects, including inhibiting the reuptake of serotonin and norepinephrine, which may contribute to its analgesic and antipyretic actions. This multifaceted mechanism of action is thought to underlie the drug's effectiveness in managing various types of pain and fever.

Non-steroidal anti-inflammatory drug (NSAID)

Tablet

The following are the uses of Metamizole Magnesium Tablet:

• Used for relieving moderate to severe pain, such as post-operative pain, dental pain, or pain associated with injuries.
• Used for reducing fever and managing high body temperatures.
• Used for treating migraine attacks to alleviate pain and associated symptoms.
• Used for managing menstrual cramps and pain during periods.
• Used for providing short-term relief from muscle spasms and related discomfort.
• Used for alleviating pain and inflammation in rheumatic conditions.
• Used for pre and post-operative pain management in surgical procedures.
• Used for managing pain and discomfort in various medical conditions as prescribed by a healthcare professional.

In the case of an overdose of Metamizole Magnesium Tablets, individuals may experience symptoms such as nausea, vomiting, and abdominal pain. The severity of the reaction depends on the amount ingested. In more serious cases, an overdose can lead to respiratory depression, hypotension, and even loss of consciousness. It is crucial to seek medical assistance promptly, providing healthcare professionals with information about the quantity consumed to ensure appropriate treatment and prevent potential complications. Timely intervention can help manage symptoms and reduce the risk of long-term health issues.

In the case of a missed dose of Metamizole Magnesium Tablet, it is important to take the dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss several doses, inform your healthcare provider, as they may advise you to restart the medication or provide alternative instructions. It is crucial to maintain a consistent medication routine, but if you frequently miss doses, consult your doctor for further guidance.

To take the Metamizole Magnesium Tablet, place the tablet on your tongue and allow it to dissolve, or swallow it whole with a glass of water, following the prescribed dosage instructions provided by your healthcare professional.

Here are the conditions and situations when Metamizole Magnesium Tablet should not be used:

• Avoid using if you have a known allergy or hypersensitivity to Metamizole Magnesium or any other pyrazolone derivatives.
• Not recommended for individuals with a history of agranulocytosis or bone marrow depression.
• Contraindicated in patients with severe heart, liver, or kidney disease.
• Should not be used by patients with an active peptic ulcer or gastrointestinal bleeding.
• Do not administer to patients with a history of asthma, especially if it is triggered by analgesics or antipyretics.
• Avoid using Metamizole Magnesium during the last trimester of pregnancy and while breastfeeding.
• Not suitable for individuals with a history of hematological disorders or those currently with low blood cell counts.
• Contraindicated in patients with porphyria, as it may trigger an attack.
• Should not be used in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Avoid using in patients with a history of seizures or epilepsy, as it may lower the seizure threshold.

The side effects of Metamizole Magnesium Tablet may include:

• Skin rashes and itching
• Allergic reactions, including anaphylaxis (a severe and potentially life-threatening allergic reaction)
• Nausea and vomiting
• Diarrhea
• Dizziness or vertigo
• Headache
• Agranulocytosis (a severe decrease in white blood cells)
• Thrombocytopenia (a decrease in platelets, which can lead to abnormal bleeding)

Following are the precautions and warnings for Metamizole Magnesium Tablet:

• Allergic reactions are possible; do not use if you are allergic to metamizole or any other ingredients in the tablet.
• This medication may cause skin reactions; immediately stop taking it and seek medical attention if you develop any skin rash, itching, or other skin-related symptoms.
• Metamizole may affect blood cell counts; regular blood tests may be required during long-term treatment.
• Not recommended for individuals with a history of agranulocytosis or bone marrow depression.
• Use with caution in patients with kidney or liver impairment, as dosage adjustments may be necessary.
• Avoid alcohol consumption while taking this medication as it may increase the risk of side effects.
• Pregnant and breastfeeding women should consult their doctor before using Metamizole Magnesium Tablets, as it may have potential risks for the fetus and infant.

Following are the drug interactions for Metamizole Magnesium Tablet:

• May interact with other non-steroidal anti-inflammatory drugs (NSAIDs), increasing the risk of gastrointestinal bleeding and kidney problems.
• Concomitant use with anticoagulants or antiplatelet drugs can enhance bleeding risk.
• Methotrexate's toxicity may be increased when used together.
• Potentially dangerous when combined with alcohol, leading to increased risk of gastrointestinal bleeding and liver damage.
• Lithium levels in the blood may be increased, requiring monitoring.
• May reduce the effectiveness of diuretics, especially loop diuretics.
• Certain antibiotics, like ciprofloxacin, may inhibit the metabolism of Metamizole, leading to higher drug levels.

Following are the food interactions for Metamizole Magnesium Tablet:

• Alcohol consumption should be avoided as it can increase the risk of gastrointestinal bleeding and liver toxicity when combined with Metamizole Magnesium.
• Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the metabolism of the drug, leading to increased levels in the blood and potential side effects.
• Caffeine-rich beverages like coffee and energy drinks may enhance the stimulant effects of Metamizole Magnesium, potentially causing restlessness and sleep disturbances.
• Fatty foods may slow down the absorption of Metamizole Magnesium, delaying its pain-relieving effects. It is advisable to take the medication on an empty stomach.
• Avoid excessive consumption of spicy foods, as they can irritate the stomach lining and potentially increase the risk of gastrointestinal side effects when taking this medication.
• Consuming high-sodium foods should be limited as Metamizole Magnesium may cause sodium retention, which can be problematic for individuals with hypertension or heart conditions.
• Avoid consuming herbal supplements like St. John's Wort, as they may affect the metabolism of Metamizole Magnesium, potentially altering its effectiveness.
• It is generally recommended to maintain a balanced diet and stay well-hydrated while taking Metamizole Magnesium to support overall health and minimize potential side effects.

Metamizole Magnesium Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct sunlight and moisture. The original packaging should be kept intact, ensuring the bottle is tightly sealed to maintain its integrity and prevent contamination. Avoid exposing the tablets to extreme temperatures, such as in the bathroom or near heat sources, as this can impact their effectiveness. Always check the expiration date, and if the tablets have passed their expiry, dispose of them carefully. Do not flush or pour them down the drain; consult a pharmacist or healthcare professional for guidance on safe disposal methods. It is crucial to keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Metamizole Magnesium Tablet:

• Consult your doctor before use, especially if you have kidney or liver problems.
• Take the tablet with a full glass of water as directed by your healthcare provider.
• Do not crush or chew the tablet; swallow it whole for effective absorption.
• Avoid alcohol consumption while taking this medication to prevent potential interactions.
• If you experience dizziness, avoid driving or operating heavy machinery until you feel steady.
• Store the medication at room temperature, away from direct sunlight and moisture.
• Always inform your doctor about all medications you are taking to ensure safe usage.