MAIORAD 3ML INJ

MAIORAD 3ML INJ

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  • Manufacturer POPULAR CHEMICAL WORKS LTD.
  • Generic Name Tiropramide

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Tiropramide injection works by acting on specific receptors in the gastrointestinal tract known as peripheral kappa-opioid receptors (KORs). It binds to these receptors, leading to a reduction in gastrointestinal motility and secretion. This mechanism helps to alleviate symptoms associated with gastrointestinal disorders, such as diarrhea and abdominal pain. By modulating the activity of KORs, tiopramide effectively slows down the movement of intestinal contents and reduces excessive fluid secretion, thereby providing relief from diarrhea and related discomfort.

  • Ingredients

    Tiropramide
  • Drug Class

    Antispasmodic

  • Dosage Form

    Injection

  • Uses

    The following are the uses of Tiropramide Injection:

    • Used for relieving pain and reducing fever in various conditions and diseases.
    • Used for managing pain associated with musculoskeletal disorders, such as arthritis and post-traumatic pain.
    • Used for treating moderate to severe pain, including postoperative pain and cancer-related pain.
    • Used for reducing high body temperature (hyperpyrexia) and managing feverish conditions.
    • Used for providing analgesia during labor and childbirth, helping to alleviate pain and discomfort.
    • Used for controlling pain and inflammation in conditions like gout and ankylosing spondylitis.
    • Used for short-term management of acute pain, such as in dental procedures or minor surgeries.
    • Used for symptomatic relief in cases of flu, colds, and other viral infections to reduce discomfort.
  • In case of Overdose

    In the case of an overdose of Tiropramide Injection, several symptoms may occur, including severe drowsiness, confusion, and respiratory depression. It is important to seek medical assistance promptly if an overdose is suspected. Treatment involves supportive care, with a focus on maintaining respiratory function and managing any complications. Prompt medical intervention is essential to ensure the best possible outcome, as the severity of symptoms can vary based on the individual's health and the amount of medication ingested.

  • Missed Dose

    In the case of a missed dose of Tiropramide Injection, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume the medication and adjust the dosing schedule if necessary. It is crucial to maintain a consistent medication routine for optimal effectiveness.

  • How To Use

    To administer Tiropramide Injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the prescribed dose subcutaneously, ensuring the entire medication is delivered before withdrawing the needle.

  • When Not to Use

    Following are the conditions when Tiropramide Injection should not be used:

    • Contraindicated in individuals with a known hypersensitivity or allergy to Tiropramide or any of the excipients in the injection.
    • Not recommended for patients with severe liver or kidney impairment.
    • Should not be used in patients with a history of seizures or epilepsy.
    • Contraindicated in patients with a known or suspected blood disorder, such as thrombocytopenia or coagulation disorders.
    • Not suitable for individuals with gastrointestinal obstruction or conditions causing slow gastrointestinal motility.
    • Should not be administered to patients with a history of drug abuse or addiction.
    • Contraindicated in pregnant and breastfeeding women due to potential risks to the fetus and infant.
    • Not recommended for children and adolescents under 18 years of age.
    • Should be used with caution and avoided if possible in elderly patients, especially those with multiple health conditions.
  • Side Effects

    The side effects of Tiropramide Injection may include:

    • Drowsiness or sleepiness
    • Dry mouth
    • Nausea and vomiting
    • Constipation
    • Blurred vision
    • Dizziness
    • Skin rash or itching
  • Precautions & Warnings

    Here are the precautions and warnings for Tiropramide Injection:

    • Tiropramide Injection should not be administered to patients with known hypersensitivity or allergy to Tiropramide or any of its excipients.
    • It is crucial to monitor for signs of anaphylaxis, and medical professionals should be prepared to treat it if it occurs.
    • This medication is not recommended for patients with severe liver impairment due to the risk of accumulation and potential toxicity.
    • Tiropramide may cause dizziness and drowsiness; patients should avoid driving, operating heavy machinery, or engaging in activities requiring mental alertness until they know how the medication affects them.
    • Elderly patients may be more susceptible to the central nervous system effects of Tiropramide, so caution and dosage adjustments may be necessary.
    • The injection should be administered slowly and under medical supervision, ensuring that the patient is appropriately monitored during and after the injection.
    • Tiropramide should be used with caution in patients with a history of epilepsy or seizures, as it may lower the seizure threshold.
    • Pregnant and breastfeeding women should consult their healthcare provider before using Tiropramide Injection, as the risks and benefits should be carefully considered.
  • Drug Interactions

    Following are the drug interactions for Tiropramide Injection:

    • Tiropramide may interact with other anticholinergic medications, leading to increased side effects such as dry mouth, blurred vision, and constipation.
    • It can enhance the sedative effects of central nervous system depressants like opioids, benzodiazepines, and alcohol.
    • Tiropramide can potentially decrease the effectiveness of certain medications used for Parkinson's disease, such as levodopa.
    • Antacids containing aluminum or magnesium may reduce the absorption of Tiropramide when taken together.
    • Drugs that inhibit certain liver enzymes (e.g., CYP3A4 inhibitors) may increase Tiropramide levels in the body, requiring dose adjustments.
    • It may interact with other medications that affect heart rhythm, such as antiarrhythmic drugs, potentially leading to irregular heartbeats.
    • Tiropramide should be used cautiously with other drugs that can cause QT prolongation, as it may increase the risk of cardiac arrhythmias.
  • Food Interactions

    Following are the food interactions to be considered with Tiopronamide Injection:

    • Avoid consuming alcohol during treatment as it may lead to increased sedation and potential liver damage.
    • Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Tiopronamide, potentially altering its effectiveness.
    • High-fat meals may slightly delay the absorption of Tiopronamide, but this is generally not clinically significant.
    • Caffeine-rich foods and beverages like coffee, tea, and energy drinks might increase nervousness and tremors, so moderation is advised.
    • Foods rich in tyramine, such as aged cheeses, cured meats, and fermented foods, should be avoided as they may interact with Tiopronamide, affecting blood pressure.
    • It's advisable to maintain a balanced diet to support overall health and ensure the medication's effectiveness.
    • Always follow your healthcare provider's dietary recommendations while using Tiopronamide Injection.
  • Storage/Disposal

    Tiropramide Injection should be stored in a controlled environment, preferably in a designated medication storage area that is clean, dry, and well-ventilated. The injection vials should be kept at room temperature, typically between 20°C and 25°C (68°F and 77°F), away from excessive heat, direct sunlight, and moisture. It is crucial to ensure that the injection is protected from freezing temperatures, as this may affect its stability and potency. Always check the expiration date on the vial before use, and discard any expired or unused vials according to local regulations and guidelines. When disposing of Tiropamide Injection, do not dispose of it in regular household waste or pour it down the sink or toilet. Instead, contact your healthcare provider or pharmacist for instructions on proper disposal methods to ensure environmental safety. Keep the medication out of the reach of children and pets to prevent accidental exposure.

  • Quick Tips, if any

    Following are the quick tips for Tiropramide Injection:

    • Administer the injection under medical supervision for safety.
    • Ensure the injection is given intramuscularly as directed.
    • Do not inject intravenously or subcutaneously.
    • Rotate injection sites to minimize tissue irritation.
    • Dispose of used needles and syringes safely.
    • Inform your doctor if you experience pain or swelling at the injection site.
    • Store the injection as directed on the packaging, away from direct sunlight.

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