Malarest (1.5g/75mg) 15ml Suspension

Artesunate and mefloquine are antimalarial drugs with distinct mechanisms of action. Artesunate primarily acts by forming reactive oxygen species when its peroxide bridge is cleaved, leading to the rapid destruction of malaria parasites, especially the more vulnerable younger forms, and it also disrupts the parasite's digestive vacuole. Mefloquine, on the other hand, interferes with the parasite's growth and development by inhibiting heme polymerase, disrupting the detoxification process, and preventing the formation of hemozoin, which is essential for the parasite's survival. This dual mechanism makes the combination effective in treating malaria, particularly in regions where resistance to other antimalarials is prevalent.

Artesunate 1.5g, Mefloquine 75g

Antimalarial

Suspension

The following are the uses of Artesunate 1.5g, Mefloquine 75g Syrup/Suspension:

• Used for the treatment of severe malaria, especially in adults and children over 20 kg.
• Used to combat Plasmodium falciparum malaria parasites.
• Used for its effectiveness in rapidly reducing malaria parasite loads.
• Used to prevent and treat acute malaria infections.
• Used for its ability to clear parasites from the body quickly, reducing the risk of severe complications.
• Used in combination with other antimalarial drugs for enhanced therapeutic effect.
• Used as an emergency treatment for severe malaria when intravenous artesunate is not available.
• Used under medical supervision, with careful monitoring of patient response and potential side effects.

In the case of an overdose of Artesunate 1.5g and Mefloquine 75g Syrup/Suspension, immediate medical intervention is necessary. Seek emergency care and inform healthcare professionals about the overdose. They will provide the necessary treatment, which may include monitoring vital signs, providing supportive care, and administering appropriate medications to counteract the effects of the overdose. Quick action can help mitigate potential health risks associated with excessive medication intake.

In the case of a missed dose of Artesunate 1.5g, administer the missed dose as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. For Mefloquine 75mg Syrup/Suspension, if a dose is missed, take it as soon as you remember. However, if it is close to the time for the next dose, skip the missed dose and resume the regular dosing frequency. Do not double the dose to make up for a missed one.

To administer Artesunate 1.5g and Mefloquine 75g Syrup/Suspension, shake the bottle well, measure the prescribed dose with an accurate measuring device, and administer it orally as directed by your healthcare provider, typically taken once with food or as instructed on the medication label.

Following are the conditions when Artesunate 1.5g and Mefloquine 75g Syrup/Suspension should not be used:

• Do not use if the patient is known to be allergic to either Artesunate or Mefloquine, or any other related antimalarial drugs.
• Contraindicated in patients with a history of severe neurological or psychiatric disorders.
• Should not be administered to infants under 3 months of age or weighing less than 5 kg.
• Not recommended for patients with severe liver or kidney disease.
• Avoid using in individuals with a known heart condition, especially those with a prolonged QT interval.
• Do not use in patients with a history of seizures or epilepsy.
• Contraindicated during the first trimester of pregnancy and in breastfeeding mothers.
• Should not be given to individuals with a known deficiency of an enzyme called G6PD (glucose-6-phosphate dehydrogenase).
• Not suitable for patients with severe vomiting, as it may affect the absorption of the medication.

The side effects of Artesunate 1.5g and Mefloquine 75g Syrup/Suspension may include:

• Nausea and vomiting.
• Diarrhea.
• Abdominal pain or discomfort.
• Dizziness or vertigo.
• Headache.
• Fatigue and weakness.
• Skin rashes or itching.
• Changes in taste.

Following are the precautions and warnings for Artesunate 1.5g, Mefloquine 75g Syrup/Suspension:

• This medication should not be used in patients with known allergies to artesunate, mefloquine, or any other ingredients in the suspension.
• Close monitoring is necessary for patients with psychiatric disorders or a history of seizures, as mefloquine may aggravate these conditions.
• Patients should be observed for any neurological or psychiatric symptoms during and after treatment, and medical attention should be sought if any unusual behavior or thoughts occur.
• Not recommended for pregnant or breastfeeding women unless the potential benefits outweigh the risks, as it may have adverse effects on the fetus or infant.
• Should be used with caution in patients with severe liver disease, as it may require dose adjustments.
• It is essential to complete the full course of treatment to ensure the effectiveness of the medication and prevent the emergence of drug-resistant parasites.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Artesunate 1.5g and Mefloquine 75g Syrup/Suspension:

• Artesunate may increase the risk of bleeding when taken with anticoagulants like warfarin, requiring close monitoring of coagulation parameters.
• Concomitant use with other antimalarial drugs, such as chloroquine or quinine, can lead to reduced effectiveness and potential resistance development.
• Mefloquine may enhance the effects of other medications that act on the central nervous system (e.g., benzodiazepines, opioids), requiring dosage adjustments.
• Anticonvulsant drugs like phenytoin or carbamazepine can decrease the effectiveness of Artesunate by increasing its metabolism.
• Artesunate may increase blood levels of certain antibiotics (e.g., doxycycline, azithromycin) when taken together.
• Caution is advised with medications that prolong the QT interval, as Mefloquine may also affect cardiac repolarization.
• Avoid using Mefloquine with other drugs that can lower the seizure threshold, such as certain antidepressants or antipsychotics.

Following are the food interactions for Artesunate 1.5g and Mefloquine 75g Syrup/Suspension:

• Artesunate may cause an upset stomach, so it is advisable to take it with food to reduce gastrointestinal discomfort.
• Fatty foods may reduce the absorption of Artesunate, so it is best to avoid high-fat meals when taking this medication.
• Mefloquine should also be taken with food to minimize gastrointestinal side effects.
• Dairy products, particularly milk, can interfere with the absorption of Mefloquine, so it is recommended to separate milk consumption from taking the medication by at least 2-3 hours.
• Grapefruit juice should be avoided as it can increase the levels of Mefloquine in the blood, potentially leading to an increased risk of side effects.
• Alcohol may exacerbate the potential side effects of both Artesunate and Mefloquine, such as dizziness, nausea, and vomiting, so it is advisable to limit or avoid alcohol consumption during treatment.
• Ensure adequate hydration by drinking plenty of fluids, especially when taking Mefloquine, as it may cause dehydration.
• No significant food interactions are known to directly impact the effectiveness of Artesunate and Mefloquine, but it is always advisable to follow healthcare provider instructions for optimal results.

Artesunate 1.5g and Mefloquine 75g Syrup/Suspension should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 20-25°C (68-77°F). Keep the medication in its original packaging, ensuring the container is tightly sealed to maintain its integrity. Avoid exposure to direct sunlight, moisture, or extreme temperatures, as these can degrade the medication. Always check the expiration date, and dispose of any unused or expired medication responsibly. Proper disposal methods include returning it to a pharmacy or following local guidelines for pharmaceutical waste disposal. Ensure the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for Artesunate 1.5g, Mefloquine 75g Syrup/Suspension:

• Ensure you understand the prescribed dosage and duration from your healthcare provider.
• Administer the syrup/suspension as directed, typically once daily or as advised.
• Shake the bottle vigorously before each use to maintain a homogeneous mixture.
• Use the provided measuring device to ensure accurate dosing.
• Consume the syrup/suspension with a full glass of water for better absorption.
• Store the medication at room temperature, away from sunlight and moisture.
• Do not share your medication with others, even if they have similar symptoms.