MalEra Max (80/480mg) 6 Tablets

Artemether and Lumefantrine are both active components in the Artemether 80mg and Lumefantrine 480mg Tablet, which work synergistically to treat malaria. Artemether, a derivative of artemisinin, acts rapidly by disrupting the parasite's digestive vacuole and inhibiting the parasite's protein synthesis. It primarily targets the early stages of the malaria parasite's lifecycle, especially the young ring-stage parasites and gametocytes. Lumefantrine, on the other hand, has a longer half-life and acts more slowly. It inhibits the parasite's vital functions by interfering with the heme detoxification pathway, thereby disrupting the parasite's energy production and metabolism. Together, the combination of artemether and lumefantrine provides a potent and effective treatment for malaria, rapidly reducing the parasite load and preventing the development of drug resistance.

Artemether 80mg, Lumefantrine 480mg

Antimalarial medication

Tablet

The following are the uses of Artemether 80mg, Lumefantrine 480mg Tablet:

• Used for the treatment of acute uncomplicated Plasmodium falciparum malaria.
• Used for malaria infections resistant to chloroquine and mefloquine.
• Used to kill malaria parasites in the blood, preventing their spread to the liver.
• Used to manage severe malaria when intravenous treatment is not feasible.
• Used as a combination therapy for increased efficacy and reduced resistance risk.
• Used to treat malaria in adults and children weighing over 11 kg.
• Used to complete the full course as prescribed for effective parasite clearance.

In the case of an overdose of Artemether 80mg and Lumefantrine 480mg tablets, individuals may experience an array of symptoms, including but not limited to nausea, vomiting, and dizziness. It is imperative to promptly seek medical assistance if an overdose is suspected. Medical professionals should be informed about the quantity ingested, as this information is crucial for determining the appropriate treatment plan. Immediate care can help mitigate potential adverse effects and ensure the well-being of the patient.

In the case of a missed dose of Artemether 80mg and Lumefantrine 480mg Tablet, it is important to take the missed dose as soon as possible. If it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. It is recommended to take the medication with food, preferably a meal containing some fat, as this can enhance the absorption of the medicine. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To take the Artemether 80mg and Lumefantrine 480mg Tablet, swallow the tablet whole with a glass of water, preferably after a meal or as directed by your healthcare provider, following the prescribed dosage and treatment duration as instructed.

Here are the circumstances when Artemether 80mg, Lumefantrine 480mg Tablet should not be administered:

• Contraindicated in individuals with a known allergy to artemether, lumefantrine, or related compounds.
• Not recommended for pregnant women, especially during the first trimester, unless the potential benefits outweigh the risks.
• Avoid use in patients with severe liver disease or impaired liver function as it may lead to increased drug toxicity.
• Not suitable for individuals with a history of prolonged QT interval or cardiac arrhythmias.
• Should not be used in patients with severe vomiting or diarrhea, as this may affect drug absorption and increase the risk of treatment failure.
• Contraindicated in patients with known severe gastrointestinal disorders, as it may interfere with drug absorption.
• Not recommended for individuals with a history of seizure disorders, as it may lower the seizure threshold.

The side effects of Artemether 80mg, Lumefantrine 480mg Tablet may include:

• Nausea and vomiting.
• Dizziness or lightheadedness.
• Loss of appetite.
• Diarrhea.
• Abdominal pain or discomfort.
• Headache.
• Weakness or fatigue.
• Skin rashes or itching.

Following are the precautions and warnings for Artemether 80mg, Lumefantrine 480mg Tablet:

• This medication should be used with caution in patients with known allergies or sensitivities to artemether, lumefantrine, or related compounds.
• Patients with a history of liver or kidney disease should be closely monitored as these conditions may affect the metabolism and elimination of the drug.
• It is essential to complete the full course of treatment as prescribed, even if symptoms improve, to ensure the complete eradication of the parasite.
• Patients with severe vomiting or diarrhea may need to be monitored for dehydration and may require additional medical attention.
• Artemether-lumefantrine should be used with caution in pregnant women only if the potential benefits outweigh the risks, and it should be avoided during the first trimester.
• Breastfeeding women should consult a healthcare professional before taking this medication as it may pass into breast milk.
• This medication may cause dizziness or blurred vision; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Keep this medication out of reach of children and pets, and store it in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Artemether 80mg, Lumefantrine 480mg Tablet:

• Concomitant use with certain antiretroviral drugs, such as efavirenz or nevirapine, may reduce the effectiveness of both Artemether and Lumefantrine.
• Drugs that induce CYP3A4 enzyme activity, like rifampicin, can decrease the plasma concentrations of Artemether and Lumefantrine, reducing their therapeutic effect.
• Anticonvulsant medications, such as phenytoin or carbamazepine, may reduce the efficacy of Artemether and Lumefantrine by increasing their metabolism.
• Co-administration with other antimalarial drugs, such as chloroquine or mefloquine, may alter the therapeutic response and increase the risk of adverse effects.
• Lumefantrine can inhibit CYP2D6 enzyme activity, potentially affecting the metabolism of drugs metabolized by this enzyme, including some antidepressants and beta-blockers.
• Artemether may enhance the effects of anticoagulants, increasing the risk of bleeding, and close monitoring is required.
• Caution is advised when combining with drugs that prolong QT interval, as Artemether may also prolong QT interval, potentially increasing the risk of arrhythmias.

Following are the food interactions for Artemether 80mg, Lumefantrine 480mg Tablet:

• Avoid consuming grapefruit or grapefruit juice as it may decrease the drug's metabolism, leading to increased levels of Artemether in the body.
• Alcohol intake should be limited or avoided as it may cause an increased risk of liver-related side effects.
• Fatty meals can reduce the absorption of Artemether, so it is recommended to take the medication on an empty stomach or with a light meal.
• Caffeine-rich foods and beverages might impact the effectiveness of the medicine, so monitor your caffeine intake.
• Spices and herbs like St. John's Wort may decrease the levels of the drug, so consult your doctor before taking any herbal supplements.
• Avoid eating or drinking dairy products within 2 hours of taking the tablet, as calcium can interfere with absorption.
• Consuming high-fat foods might delay the absorption of Lumefantrine, so consider a low-fat diet during the medication period.
• Ensure a balanced diet rich in nutrients to support overall health and recovery during treatment.

Artemether 80mg, Lumefantrine 480mg Tablets should be stored in a cool and dry place, preferably at room temperature (below 25°C). Protect the tablets from direct sunlight, moisture, and heat as these conditions can affect the potency of the medication. Keep the tablets in their original packaging or container, tightly sealed, to maintain their integrity. It is important to check the expiration date before use and discard any medication that is past its expiry. For disposal, do not throw the tablets into household trash or flush them down the toilet; instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for appropriate methods to ensure safe and environmentally friendly disposal. Keep the medication out of the reach of children and pets to prevent accidental ingestion.

Following are the quick tips for Artemether 80mg, Lumefantrine 480mg Tablet:

• Ensure you complete the full course of medication as prescribed by your doctor.
• Take the tablet with a meal or a milky drink to enhance absorption.
• Maintain a consistent dosing schedule by taking the medication at the same time each day.
• Store the tablets in a cool, dry place, away from direct sunlight.
• Inform your doctor if you have any liver or kidney issues before taking this medication.
• Do not crush or chew the tablet; swallow it whole with water.
• If you experience any severe side effects, such as skin rash or breathing difficulties, seek immediate medical attention.