MARAX TAB

Ephedrine primarily acts as a sympathomimetic agent, stimulating alpha and beta-adrenergic receptors. It increases the release of norepinephrine, leading to vasoconstriction, bronchodilation, and increased heart rate. On the other hand, Hydroxyzine is an antihistamine that competitively binds to H1-receptor sites, inhibiting the action of histamine. This binding reduces histamine-induced symptoms such as itching, vasodilation, and increased capillary permeability. Together, these components of the tablet work synergistically to provide both bronchodilatory and anti-allergic effects.

Ephedrine 25 mg, Hydroxyzine [ 10 mg]

Sympathomimetic

Antihistamine

Tablet

1

In the case of an overdose of Ephedrine 25 mg and Hydroxyzine 10 mg tablets, prompt medical intervention is necessary. Ingesting excessive amounts of these medications can lead to serious health complications. Symptoms may include rapid heartbeat, dizziness, severe headache, and even seizures. If an overdose is suspected, it is crucial to contact a healthcare professional or poison control center immediately for guidance on the appropriate treatment and management of potential adverse effects. Timely action can prevent severe consequences.

In the case of a missed dose of Ephedrine 25 mg, it is recommended to take the missed dose as soon as you remember, but if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Hydroxyzine 10 mg tablets, if you miss a dose, take it as soon as you remember, however, if it's close to the time for your next dose, skip the missed dose and resume your regular dosing pattern. It's important not to double the dose to make up for a missed one. Consult your healthcare provider if you have any concerns or questions about missed doses.

To take the Ephedrine 25 mg and Hydroxyzine 10 mg tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions or situations when Ephedrine 25 mg, Hydroxyzine [10 mg] Tablet should not be used:

• Should not be taken if you have an allergy to Ephedrine, Hydroxyzine, or any other similar medications.
• Not suitable for individuals with narrow-angle glaucoma.
• Contraindicated in patients with severe high blood pressure, heart disease, or blood vessel disorders.
• Should not be used if you have a history of seizures or epilepsy.
• Avoid using this medication if you have an enlarged prostate or difficulty urinating.
• Not recommended for individuals with liver or kidney disease.
• Do not take this medication if you have a history of mental health disorders or suicidal thoughts.
• Contraindicated during breastfeeding as it may pass into breast milk.
• Should not be used in children below a certain age, as determined by a healthcare professional.

The side effects of Ephedrine 25 mg and Hydroxyzine 10 mg Tablet may include:

• Increased heart rate
• Elevated blood pressure
• Restlessness or insomnia
• Dizziness or lightheadedness
• Dry mouth
• Nausea or vomiting
• Fatigue or weakness
• Skin rash or itching

Following are the precautions and warnings for Ephedrine 25 mg, Hydroxyzine 10 mg Tablet:

• Allergic reactions may occur; discontinue use if signs of allergy or hypersensitivity are observed.
• Not recommended for patients with cardiovascular disease due to potential cardiac stimulation.
• Ephedrine may cause nervousness, dizziness, or tremors, and should be used with caution in patients with anxiety, hyperthyroidism, or seizure disorders.
• Monitor blood pressure and heart rate regularly during treatment, especially in patients with hypertension.
• Hydroxyzine may cause sedation and impaired coordination; avoid activities requiring mental alertness and coordination.
• Avoid alcohol consumption as it may intensify the sedative effects of Hydroxyzine.
• Elderly patients may be more susceptible to side effects; use with caution and adjust dosage as needed.
• Consult a healthcare professional if you are pregnant, breastfeeding, or planning to become pregnant.

Following are the drug interactions for Ephedrine 25 mg and Hydroxyzine 10 mg Tablet:

• Ephedrine may interact with other central nervous system stimulants, increasing the risk of hypertension and cardiovascular side effects.
• It can interact with monoamine oxidase inhibitors (MAOIs), potentially causing a hypertensive crisis.
• Avoid using with other sympathomimetic drugs, as it may lead to increased cardiovascular risks.
• Hydroxyzine can potentiate the effects of central nervous system depressants, including alcohol, opioids, and benzodiazepines.
• Antihistamines like Hydroxyzine may interfere with the action of levodopa and other antiparkinsonian medications.
• Concomitant use with other anticholinergic drugs may increase the risk of side effects such as dry mouth, blurred vision, and urinary retention.
• Drugs metabolized by CYP450 enzymes, particularly CYP2D6 and CYP3A4, may have altered metabolism when used with Hydroxyzine.

Following are the food interactions for Ephedrine 25 mg, Hydroxyzine [ 10 mg] Tablet:

• Avoid consuming caffeine-rich foods and beverages like coffee, tea, chocolate, and energy drinks, as the combination with ephedrine may increase heart rate and blood pressure, potentially leading to cardiovascular issues.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of hydroxyzine, leading to increased drug levels in the blood and potential side effects like dizziness and sedation.
• Alcohol consumption should be limited as it can enhance the sedative effects of hydroxyzine, increasing the risk of dizziness, drowsiness, and impaired coordination.
• Avoid high-fat meals as they may delay the absorption of ephedrine, affecting its effectiveness and potentially prolonging its presence in the body.
• Spicy foods may increase the absorption rate of hydroxyzine, potentially leading to higher drug levels and increased side effects.
• Dairy products, especially milk, can interact with hydroxyzine, reducing its absorption. It is advisable to separate milk consumption from medication intake by a few hours.
• Consuming potassium-rich foods like bananas, oranges, and spinach is essential when taking ephedrine, as it may cause potassium depletion.
• Herbal supplements, particularly St. John's Wort, should be avoided as they can impact the metabolism of hydroxyzine.

The storage and disposal of Ephedrine 25 mg and Hydroxyzine 10 mg tablets require careful attention. Keep the tablets in a cool and dry place, away from direct sunlight and moisture, preferably in their original container with the lid tightly secured. Avoid exposing them to high temperatures or humidity, as this can impact their effectiveness. Regularly check the expiration date, and properly dispose of any unused or expired tablets. Do not flush them or pour them down the drain; instead, seek guidance from a pharmacist or healthcare professional for safe disposal practices. It is crucial to keep these medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Ephedrine 25 mg and Hydroxyzine 10 mg tablets:

• Consult a doctor for the correct dosage and prescription.
• Swallow the tablets whole with a full glass of water.
• Do not crush or chew the tablets.
• Take the medication as directed, typically with or without food.
• Avoid consuming alcohol or caffeine while on this medication.
• Store in a cool, dry place, away from direct sunlight.
• Inform your doctor about any other medications you are taking.
• Seek immediate medical attention if you experience any severe side effects.