MARVELON 1 21'S

Desogestrel is a progestin-only medication that primarily works by inhibiting ovulation. Its mechanism of action involves binding to and activating the progesterone receptors in the body. This activation suppresses the release of gonadotropin hormones, particularly luteinizing hormone (LH). Normally, a surge in LH triggers ovulation, but desogestrel's interference with this process prevents the release of an egg from the ovary (ovulation). This is achieved by inhibiting the mid-cycle LH surge and reducing the frequency of GnRH (gonadotropin-releasing hormone) pulses. As a result, desogestrel effectively blocks the hormonal cascade required for ovulation, making it a reliable contraceptive agent.

Desogestrel

Progestin.

Tablet

The following are the uses of Desogestrel Tablet:

• Used for preventing pregnancy
• Used for regulating irregular menstrual cycles
• Used for treating acne and hormonal imbalances
• Used for reducing menstrual pain and heavy bleeding
• Used for managing endometriosis symptoms
• Used for delaying menstruation for special events or vacations
• Used for alleviating premenstrual syndrome (PMS) symptoms
• Used for providing long-term contraception and cycle control

In the case of an overdose of Desogestrel Tablets, the individual may experience nausea, vomiting, and dizziness. These symptoms can be more severe in children or elderly individuals. It is important to seek medical advice immediately if an overdose is suspected. Treatment may involve supportive care and monitoring of vital signs, as well as addressing any specific symptoms that arise from the overdose. Prompt action can help mitigate potential health risks associated with Desogestrel Tablet overdoses.

In the case of a missed dose of Desogestrel Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, it is recommended to use a backup method of contraception, such as condoms, until you have taken the medication consistently for at least 7 days. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take Desogestrel Tablets, swallow one tablet at the same time each day, preferably with water, following the instructions provided by your healthcare professional, and ensure you take it consistently every day to maintain its effectiveness.

Following are the conditions or situations when Desogestrel Tablet should not be used:

• Should not be used in individuals with a known allergy to Desogestrel or any other progestin hormones.
• Contraindicated in women who are breastfeeding, as it may reduce milk production.
• Not suitable for individuals with a history of blood clots or current blood clotting disorders.
• Should not be used in patients with a history of stroke or heart attack.
• Contraindicated in individuals with liver tumors or active liver disease.
• Not recommended for women with undiagnosed abnormal vaginal bleeding.
• Should not be used in patients with severe hypertension (high blood pressure).
• Contraindicated in smokers, especially those over 35 years of age, due to increased cardiovascular risks.
• Not suitable for individuals with a history of breast cancer or any known or suspected breast cancer.

The side effects of Desogestrel Tablet may include:

• Nausea and vomiting
• Headaches or migraines
• Breast tenderness or pain
• Mood changes, including depression or irritability
• Changes in menstrual bleeding patterns (lighter, irregular, or absent periods)
• Weight gain or loss
• Skin changes, such as acne or rashes
• Decreased libido

Following are the precautions and warnings:

• Desogestrel tablets should not be used by women who are pregnant or planning to become pregnant, as they can cause birth defects.
• This medication is intended for oral use only and should not be crushed, chewed, or broken, as it may reduce its effectiveness.
• Patients with a history of blood clots, stroke, or heart attack should not use Desogestrel without medical advice, as it may increase the risk of these conditions.
• Smoking cigarettes while taking Desogestrel can increase the likelihood of adverse cardiovascular effects; it is advisable to quit smoking.
• Caution is advised for individuals with a history of breast cancer, liver disease, or diabetes, as Desogestrel may affect these conditions.
• Desogestrel may increase the risk of gallbladder issues; monitor for symptoms like abdominal pain and yellowing of the skin or eyes.
• It is essential to inform your healthcare provider about all medications you are taking, including herbal supplements, to avoid potential drug interactions.
• Women over 35 who smoke and use Desogestrel may be at higher risk for severe side effects and should seek regular medical check-ups.

Following are the drug interactions for Desogestrel Tablet:

• Desogestrel may decrease the effectiveness of drugs metabolized by CYP3A4, such as antifungals (e.g., ketoconazole) and antibiotics (e.g., rifampin).
• Ethinyl estradiol in combination with desogestrel can reduce the efficacy of lamotrigine, leading to breakthrough seizures.
• Grapefruit juice can increase plasma concentrations of desogestrel, potentially increasing the risk of side effects.
• St. John's Wort may decrease the effectiveness of desogestrel by inducing its metabolism.
• Rifampin and other enzyme inducers can reduce the plasma concentrations of desogestrel, possibly reducing its contraceptive efficacy.
• Antiretroviral agents (e.g., ritonavir) may reduce the effectiveness of desogestrel by accelerating its metabolism.
• Desogestrel may affect the metabolism of corticosteroids, potentially altering their therapeutic effects.

Following are the food interactions for Desogestrel Tablet:

• Grapefruit and grapefruit juice consumption should be limited as they may increase the blood levels of Desogestrel, potentially leading to increased side effects.
• Avoid alcohol as it may reduce the effectiveness of the medication and increase the risk of side effects such as nausea and dizziness.
• High-fat meals can delay the absorption of Desogestrel, possibly reducing its efficacy, so it is best to take the tablet on an empty stomach.
• Caffeine intake should be monitored as it may interfere with the hormone balance in the body, affecting the medication's effectiveness.
• Avoid herbal supplements like St. John's Wort, as they can reduce Desogestrel levels in the blood, compromising its contraceptive action.
• Vitamin C-rich foods are safe to consume, but extremely high doses of vitamin C supplements might affect hormone levels, so moderation is key.
• Avoid excessive salt intake, as Desogestrel may lead to increased salt retention, impacting blood pressure.
• Maintain a balanced diet; no specific food restrictions are necessary unless advised by a healthcare professional.

Desogestrel Tablets should be stored in a cool, dry area, ideally at room temperature, ensuring protection from light and moisture. It is crucial to keep the tablets in their original packaging, securely sealed to maintain their integrity. Avoid placing them in bathrooms or near heat-emitting appliances like ovens or heaters, as temperature fluctuations can impact the medication's effectiveness. Dispose of any unused or expired tablets with caution; refrain from flushing them or pouring them down the drain. Consult a pharmacist or healthcare professional for guidance on proper disposal methods. Additionally, ensure the tablets are stored out of children's reach to prevent accidental consumption.

Following are the quick tips for Desogestrel Tablet:

• Consult your healthcare provider for personalized instructions and dosage guidance.
• Take the tablet by mouth as directed, preferably at the same time each day.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent daily routine for better effectiveness.
• Inform your doctor about all medications you're taking to avoid interactions.
• If you experience nausea, taking the tablet with food may help.
• Store the tablets at room temperature, away from moisture and light.