Maxidex (0.1%) 10ml Eye Drops

Dexamethasone eye drops primarily exert their effects by acting as a potent synthetic corticosteroid. Upon administration to the eye, dexamethasone binds to intracellular glucocorticoid receptors, initiating a cascade of anti-inflammatory and immunosuppressive actions. These actions include inhibiting the production and release of various inflammatory mediators, such as prostaglandins, leukotrienes, and cytokines, which are typically involved in the inflammatory response. By suppressing the activity of these mediators, dexamethasone effectively reduces inflammation, swelling, and irritation in the eye. It also stabilizes the cell membrane, preventing the release of additional inflammatory substances, and inhibits the migration of immune cells to the site of inflammation, thereby minimizing tissue damage and promoting healing in ocular conditions.

Dexamethasone

Corticosteroid

Drop

The following are the uses of Dexamethasone Drop:

• Used for reducing inflammation and suppressing the immune response in the eyes, often prescribed for eye conditions such as allergic conjunctivitis, uveitis, and corneal issues.
• Used for treating severe eye allergies, helping to alleviate itching, redness, and swelling.
• Used as a post-operative eye drop to reduce inflammation and aid in healing after eye surgeries or procedures.
• Used to manage inflammatory eye conditions like iritis or keratitis, providing relief from pain and irritation.
• Used in cases of ocular herpes to reduce inflammation and discomfort caused by the virus.
• Used to prevent or treat eye damage in certain medical conditions, such as Steven-Johnson Syndrome or erythema multiforme.
• Used for emergency treatment of chemical burns or other eye injuries to reduce swelling and promote healing.

To be taken as per doctor's prescription

In the case of an overdose of Dexamethasone Drops, immediate action should be taken. Symptoms may include increased thirst, frequent urination, muscle weakness, and mood changes. If ingested orally, vomiting and stomach irritation can occur. Seek medical advice promptly, as prolonged exposure to high doses can lead to more severe health complications, such as Cushing's syndrome and adrenal gland suppression. Timely intervention is vital to mitigate potential risks.

In the case of a missed dose of Dexamethasone Drops, it is important to act promptly. If you remember within a few hours of the missed dose, administer the medication as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is best to consult your healthcare provider if you frequently miss doses to determine the best course of action.

To use Dexamethasone Drops, gently tilt your head back, pull the lower eyelid down to create a pocket, and instill the prescribed number of drops into the eye, then close your eyes gently to allow the medication to absorb.

Following are the conditions/situations when Dexamethasone Eye Drops should not be used:

• Should not be used if you have a known allergy or hypersensitivity to Dexamethasone or any other corticosteroid medication.
• Not recommended for individuals with untreated or uncontrolled infections in the eye, especially viral or fungal infections.
• Contraindicated in patients with a history of recent eye surgery, injury, or trauma, as it may delay healing.
• Avoid using it if you have a current or recent history of glaucoma or ocular hypertension.
• Not suitable for individuals with corneal ulcers or thinning.
• Should not be used if you have a fungal infection of the eye.
• Avoid using Dexamethasone drops if you have a history of eye herpes (herpes simplex keratitis).

The side effects of Dexamethasone Drop may include:

• Stinging or burning sensation in the eye
• Blurred vision
• Increased eye pressure (especially in patients with glaucoma)
• Itching or redness of the eye
• Dry eyes
• Eye discharge
• Increased risk of eye infections

Following are the precautions and warnings:

• Dexamethasone eye drops should not be used by individuals with a known allergy or hypersensitivity to dexamethasone or any of the other ingredients in the eye drops.
• Do not wear contact lenses while using these drops; wait until the treatment is completed.
• These drops are for external eye use only; do not swallow or inject.
• Prolonged use of corticosteroid eye drops may lead to increased intraocular pressure, glaucoma, or cataracts. Regular eye pressure checks are necessary during treatment.
• Avoid using other eye medications without medical advice to prevent potential interactions.
• If you have existing eye infections or injuries, consult a doctor before using these drops.
• Do not exceed the prescribed dosage or duration of treatment to prevent potential side effects.
• If you experience eye pain, changes in vision, or worsening of symptoms, discontinue use and seek medical attention immediately.

Following are the drug interactions for Dexamethasone Drop:

• May increase intraocular pressure when used with other topical ophthalmic medications, such as epinephrine or dipivefrin.
• Dexamethasone can decrease the effectiveness of live vaccines; avoid or delay vaccination during treatment.
• Concomitant use with nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal bleeding.
• Anticoagulants like warfarin may have their effects potentiated, requiring close monitoring of coagulation parameters.
• Drugs metabolized by CYP3A4 enzymes, such as cyclosporine or tacrolimus, may have increased blood levels when used with dexamethasone.
• May increase the risk of hypokalemia when used with diuretics, especially potassium-wasting diuretics.
• Caution with antidiabetic medications, as dexamethasone can increase blood glucose levels.

Following are the food interactions for Dexamethasone Drops:

• Dexamethasone may cause increased appetite, so monitor your food intake to avoid excessive weight gain.
• It can also lead to fluid retention, so reducing salt intake is advisable to prevent swelling and high blood pressure.
• Avoid high-sugar foods and beverages as Dexamethasone can cause elevated blood sugar levels.
• Caffeine consumption should be limited as it can worsen insomnia, a potential side effect of the medication.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of Dexamethasone, potentially leading to increased side effects.
• Alcohol may increase the risk of gastrointestinal issues and should be consumed in moderation or avoided.
• Ensure adequate calcium and vitamin D intake, as prolonged use of Dexamethasone can affect bone health.
• A balanced diet is essential to manage potential side effects and maintain overall health while using Dexamethasone Drops.

Dexamethasone Drops should be stored in a cool, controlled environment, preferably between 68°F and 77°F (20°C and 25°C), and kept away from excessive heat, moisture, or direct sunlight. Ensure the bottle is tightly sealed after each use to maintain its integrity and prevent contamination. Do not freeze the solution. If the medication is past its expiration date or no longer needed, proper disposal is crucial. Contact your pharmacist or healthcare provider for guidance on safe disposal methods, and never flush or pour the medication down the drain, as it can impact the environment. Keep the medication out of the reach of children and pets to prevent accidental ingestion.

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Following are the quick tips for Dexamethasone Drops:

• Wash your hands thoroughly before administering the eye drops to maintain hygiene.
• Tilt your head back, gently pull down your lower eyelid, and instill the prescribed number of drops into the eye.
• Close your eyes gently after administering the drops and apply light pressure to the inner corner of the eye to prevent drainage.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• If you are using other eye medications, wait at least 5 minutes before applying the next medication to ensure proper absorption.
• Store the eye drops at room temperature, away from direct sunlight and moisture.
• Do not wear contact lenses while using these drops unless your doctor advises otherwise.