MAXITROL EYE DROP 10ML

Dexamethasone, a potent synthetic corticosteroid, exerts its anti-inflammatory and immunosuppressive effects by binding to glucocorticoid receptors, modulating gene expression, and reducing the production of pro-inflammatory mediators. Neomycin Sulphate is an aminoglycoside antibiotic that binds to the bacterial ribosome, disrupting protein synthesis and leading to bacterial cell death. Polymyxin B Sulphate, a cyclic polypeptide antibiotic, disrupts the integrity of the bacterial cell membrane, causing rapid cell death, particularly in gram-negative bacteria. This combination's synergistic action helps reduce inflammation, control bacterial infections, and prevent the release of inflammatory mediators, making it effective in managing various ocular conditions.

Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate

1. Dexamethasone:

drop

The following are the uses of Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Drop:

• Used for treating eye infections and inflammation
• Used to reduce redness and swelling in the eye
• Effective against bacterial eye infections
• Helps manage allergic eye conditions
• Provides relief from eye itching and irritation
• Aids in preventing eye infection after eye surgery
• Used to prevent and treat eye infections in newborns
• Promotes healing of corneal injuries

In the case of an overdose of Dexamethasone, Neomycin Sulphate, and Polymyxin B Sulphate Drops, symptoms may include increased heart rate, high blood pressure, and potential damage to the kidneys. If ingested orally, nausea, vomiting, and diarrhea may occur. It is important to seek medical advice immediately if an overdose is suspected, as prompt treatment can help manage these symptoms effectively. Medical professionals may induce vomiting or administer activated charcoal to reduce absorption.

In the case of a missed dose of Dexamethasone, apply the eye drops as soon as you remember, but if it's almost time for the next dose, skip the missed dose and continue with your regular schedule. For Neomycin Sulphate and Polymyxin B Sulphate Drops, if you miss a dose, apply it as soon as possible, but if it's almost time for your next dose, skip the missed dose and return to your regular dosing schedule. It's important to not double the dose to make up for a missed one.

To use the Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate eye drops, gently tilt your head back, pull the lower eyelid down to create a pocket, and hold the dropper above the eye; release one drop into the pocket, blink gently, and keep your eyes closed for 1-2 minutes to allow the medication to absorb.

Following are the conditions or situations when Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Eye Drops should not be used:

• Should not be used if you are allergic to any of the active ingredients (Dexamethasone, Neomycin, or Polymyxin B) or any other components in the eye drops.
• Not recommended for individuals with viral, fungal, or mycobacterial infections of the eye, as these eye drops are not effective against such infections.
• Should not be used to treat or prevent systemic infections.
• Contraindicated in patients with known hypersensitivity or allergic reactions to other aminoglycoside antibiotics (similar to Neomycin and Polymyxin B).
• Not suitable for long-term use due to the risk of side effects, especially with prolonged use.
• Should not be used in patients with a history of corneal ulcers or perforation, as these conditions may worsen with the use of corticosteroids.
• Not recommended for individuals with a history of ocular herpes simplex (a viral eye infection), as corticosteroids can potentially trigger or worsen this condition.

The side effects of Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Drop may include:

• Eye irritation or burning sensation
• Increased eye pressure (intraocular pressure)
• Blurred vision
• Allergic reactions such as itching, redness, or swelling of the eyes
• Skin rash or itching
• Ear discomfort or temporary hearing changes
• Dryness or discomfort in the nose or throat.

Following are the precautions and warnings for Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Eye/Ear Drops:

• Do not use if you are allergic to any of the ingredients, including dexamethasone, neomycin, or polymyxin B.
• Avoid using this medication if you have a history of hypersensitivity or allergic reactions to similar medications.
• If you have existing eye or ear infections, especially viral or fungal infections, consult a doctor before use.
• Prolonged use of this medication can lead to increased ocular pressure and potential damage to the optic nerve; regular monitoring is necessary.
• Patients with pre-existing conditions such as tuberculosis, herpes simplex, or mycosis should be closely monitored during treatment.
• Children and elderly patients should use this medication with caution and under medical supervision.
• If you experience persistent or worsening symptoms, discontinue use and seek medical advice immediately.

Following are the drug interactions for Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Drop:

• Concurrent use with other ototoxic drugs (e.g., aminoglycosides, loop diuretics) may increase the risk of hearing impairment.
• Topical dexamethasone may interact with systemic corticosteroids, leading to increased systemic effects and potential suppression of the hypothalamic-pituitary-adrenal (HPA) axis.
• Caution is advised when using with other immunosuppressant drugs, as it may increase the risk of infection.
• The use of Neomycin with other nephrotoxic drugs (e.g., amphotericin B, cisplatin) may increase the risk of kidney damage.
• Polymyxin B may interact with other neuromuscular blocking agents, enhancing their effects and potentially leading to respiratory depression.
• Concomitant use with other aminoglycosides may increase the risk of ototoxicity and nephrotoxicity.
• The drop may reduce the effectiveness of live attenuated vaccines, and vaccination schedules should be adjusted accordingly.

Following are the food interactions for Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Drop:

• Avoid excessive salt (sodium) in your diet as Dexamethasone can cause sodium retention, leading to increased blood pressure and fluid retention.
• Limit the consumption of foods containing high levels of vitamin K (such as leafy green vegetables, broccoli, and liver) as Neomycin Sulphate may interfere with vitamin K absorption, affecting blood clotting.
• Polymyxin B Sulphate can be affected by high-fat meals, which may increase its absorption and potentially lead to increased side effects.
• Avoid alcohol consumption as it may increase the risk of gastrointestinal issues and may also affect the effectiveness of Dexamethasone.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Dexamethasone, leading to increased drug levels in the body.
• Dairy products, especially milk, may decrease the absorption of Polymyxin B Sulphate, so consider separating milk intake from medication timing.
• Maintain a balanced diet and stay hydrated to support overall health and minimize potential side effects of these medications.
• Always consult your healthcare provider for personalized advice regarding food interactions and medication management.

Dexamethasone, Neomycin Sulphate, and Polymyxin B Sulphate Eye Drops require careful storage and disposal to maintain their effectiveness and ensure safety. Store the eye drops in a cool, dry place, preferably at room temperature, and protect them from direct sunlight and moisture. Keep the bottle tightly sealed to maintain sterility and prevent contamination. Avoid extreme temperatures by not storing them in the refrigerator, freezer, or near heat sources. Always check the expiration date before use, and never use the drops if they have expired. Dispose of any remaining solution and its container responsibly by following local guidelines for pharmaceutical waste disposal. Keep the medication out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Drops:

• Wash your hands thoroughly before administering the eye drops to maintain hygiene.
• Tilt your head back, gently pull down your lower eyelid, and instill the prescribed number of drops into the eye.
• Close your eyes gently and apply light pressure to the inner corner of the eye for a few minutes to minimize drainage.
• Avoid touching the dropper tip to any surface, including your eye or hands, to prevent contamination.
• If you are using other eye medications, wait at least 5-10 minutes before applying the next medication.
• Store the eye drops at room temperature, away from direct sunlight and moisture.
• Do not use the eye drops if the solution changes color or becomes cloudy.