MAXITROL OINT

Dexamethasone, Neomycin Sulfate, and Polymyxin B Sulfate Ointment has a combined mechanism of action. Dexamethasone is a potent synthetic corticosteroid that reduces inflammation by suppressing various immune and inflammatory responses. It inhibits the release of inflammatory mediators, reduces capillary permeability, and stabilizes cell membranes. Neomycin Sulfate is an aminoglycoside antibiotic that kills bacteria by binding to their ribosomes, disrupting protein synthesis, and ultimately leading to bacterial cell death. Polymyxin B Sulfate is a cyclic polypeptide antibiotic that disrupts the structure of the bacterial cell membrane, leading to cell death. It binds to the cell membrane of gram-negative bacteria, displacing divalent cations and disrupting the integrity of the membrane, resulting in bacterial lysis. Together, these components provide anti-inflammatory and antibacterial effects, making the ointment effective for treating various skin infections and inflammatory conditions.

Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate

Corticosteroid and Antibiotic

Ointment

The following are the uses of Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Ointment:

• Used for treating eye infections and inflammation, particularly bacterial infections and allergic reactions.
• Used to prevent and treat eye infections after injuries, surgeries, or in cases of corneal ulcers.
• Used to manage inflammatory eye conditions such as conjunctivitis and uveitis, reducing redness and swelling.
• Used for relieving eye irritation, itching, and discomfort caused by allergies or foreign bodies.
• Used as a preventive measure to avoid eye infections in high-risk situations or for contact lens wearers.
• Used for treating ear infections and inflammation, especially bacterial infections and ear canal inflammation.
• Can be applied to reduce swelling and itching in specific skin conditions, under medical supervision.

In the case of an overdose of Dexamethasone, Neomycin Sulphate, and Polymyxin B Sulphate Ointment, the effects can vary depending on the amount ingested. Ocular and otic exposure may result in transient burning or irritation. If a large amount is swallowed, symptoms such as increased thirst, muscle weakness, and changes in mood or behavior may occur. Promptly seek medical advice for appropriate treatment and management.

In the case of a missed dose of Dexamethasone, apply the ointment as soon as you remember, but if it's almost time for the next dose, skip the missed application and continue with your regular schedule. For Neomycin Sulphate and Polymyxin B Sulphate, if you forget to apply the ointment, administer it as soon as you notice and then adjust the timing of the next application accordingly. It's important to follow the prescribed schedule as closely as possible to ensure the medication's effectiveness.

To use the Dexamethasone, Neomycin Sulphate, and Polymyxin B Sulphate Ointment, gently apply a thin layer of the ointment to the affected area, typically twice a day or as directed by your healthcare provider, ensuring that you clean and dry the area before application and wash your hands thoroughly after use.

Here are the conditions and situations when Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Ointment should not be used:

• Avoid using this ointment if you have a known allergy or sensitivity to any of the active ingredients, such as Dexamethasone, Neomycin, or Polymyxin B, or any of the inactive ingredients in the ointment.
• Do not use this ointment in or around the eyes, as it may cause severe eye irritation and damage.
• Not recommended for individuals with viral, fungal, or tubercular lesions, as it is not effective against these types of infections.
• Should not be used on broken or severely damaged skin, such as deep wounds or burns.
• Contraindicated in patients with a history of hypersensitivity or allergic reactions to similar antibiotic or corticosteroid medications.
• Not suitable for long-term use, as prolonged use may lead to skin thinning, bacterial resistance, or other adverse effects.
• Avoid using this ointment on large areas of the body or for extended periods without medical supervision.
• Do not use this ointment on children, especially infants, without medical advice, as their skin is more sensitive and may absorb medications differently.

The side effects of Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Ointment may include:

• Increased intraocular pressure (pressure inside the eyes)
• Glaucoma (eye condition)
• Skin irritation or burning at the application site
• Itching or rash
• Allergic reactions (such as hives, swelling, or difficulty breathing)
• Hearing loss or ringing in the ears (tinnitus)
• Ear pain or discomfort
• Kidney problems (when used for a prolonged period)

Following are the precautions and warnings for Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Ointment:

• Avoid using this ointment if you are allergic to any of its ingredients, including dexamethasone, neomycin, or polymyxin B.
• Do not apply the ointment near the eyes, as it may cause irritation or damage.
• Do not use this medication for extended periods without medical supervision, as long-term use can lead to thinning of the skin.
• If you have an active or suspected infection, consult a healthcare professional before using this ointment, as it may mask the symptoms.
• Patients with existing skin conditions, such as eczema or psoriasis, should use it with caution, as it may exacerbate these conditions.
• Avoid using tight-fitting bandages or dressings over the treated area, as this may increase the risk of side effects.
• If you are pregnant or breastfeeding, consult your doctor before using this medication, as it may have potential risks for the fetus or infant.
• Discontinue use and seek medical attention if you experience severe or persistent side effects, such as skin irritation, burning, or allergic reactions.

Following are the drug interactions for Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Ointment:

• Other topical medications or ointments may interact, so consult a pharmacist before combining with other topical treatments.
• Dexamethasone may interact with oral corticosteroids, increasing the risk of systemic side effects. Monitoring for adverse reactions is necessary.
• Neomycin can interact with systemic aminoglycosides, potentially enhancing ototoxicity and nephrotoxicity. Regular hearing and kidney function tests are advised.
• Polymyxin B can interact with other polymyxins or similar antibiotics, increasing the risk of neurotoxicity and nephrotoxicity. Close monitoring is required.
• Drugs that prolong the QT interval, such as certain antiarrhythmics or antipsychotics, may interact with Dexamethasone, requiring ECG monitoring.
• The use of live virus vaccines during or shortly after Dexamethasone treatment is not recommended, as it may decrease the vaccine's effectiveness.
• Drugs that affect the metabolism of Dexamethasone, such as CYP3A4 inducers or inhibitors, can alter its effectiveness.

Following are the food interactions for Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Ointment:

• Avoid high-sodium foods, as Dexamethasone can cause sodium retention, leading to increased blood pressure.
• Limit the consumption of foods containing live cultures, such as yogurt or fermented items, as Neomycin Sulphate may reduce the effectiveness of these beneficial bacteria.
• Avoid consuming excessive amounts of vitamin K-rich foods like leafy greens, as Dexamethasone can interfere with blood clotting.
• Grapefruit and grapefruit juice should be avoided due to potential interactions with Polymyxin B Sulphate, affecting drug metabolism.
• Alcohol may increase the risk of gastrointestinal issues when combined with Dexamethasone; thus, moderation is advised.
• Ensure adequate hydration by drinking plenty of fluids, especially water, to prevent potential dehydration while using this medication.
• No significant food interactions are reported with Polymyxin B Sulphate, but maintaining a balanced diet is recommended for overall health.

Dexamethasone, Neomycin Sulphate, and Polymyxin B Sulphate Ointment should be stored in a cool, dry area, preferably at room temperature, away from direct sunlight and moisture. The original packaging should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to expose the ointment to extreme temperatures, so avoid storing it in hot or humid environments like bathrooms or near heat sources. Dispose of any unused or expired ointment responsibly; do not flush it or pour it down the drain. Consult your pharmacist or healthcare professional for guidance on proper disposal methods. Always keep medications securely stored, out of the reach of children, to prevent accidental exposure or ingestion.

Following are the quick tips for Dexamethasone, Neomycin Sulphate, Polymyxin B Sulphate Ointment:

• Wash your hands before and after applying the ointment to maintain hygiene.
• Clean and dry the affected area before applying the ointment.
• Use a thin layer of ointment and gently spread it over the affected area.
• Avoid applying the ointment to broken or irritated skin.
• Do not cover the treated area with a bandage unless directed by your doctor.
• Store the ointment at room temperature, away from direct sunlight and moisture.
• Inform your doctor if you experience any vision changes, persistent skin irritation, or signs of infection.