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Medifin SR (100mg) 30 Tablets

Medifin SR (100mg) 30 Tablets

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  • Manufacturer 3S Pharmaceuticals (Pvt.) Ltd.

Product Information

  • Description

    (Diclofenac) belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs), which are used to treat pain and inflammation. Diclofenac sodium, a phenyl acetic acid derivative, is chemically described as 2-[(2, 6-dichlorophenyl) amino] benzene acetic acid, monosodium salt. Diclofenac works by inhibiting cyclooxygenase-1 and -2, the enzymes that are responsible for production of a prostaglandin; (PG) G2, which is the precursor to other prostaglandins. These molecules have broad actions in the mechanism of pain and inflammation and the inhibition of production of these prostaglandins by diclofenac results in cure from inflammation and pain.
  • Dosage Form

    Sustained Release Tablet
  • Uses

    Rheumatoid Arthritis, Osteoarthritis, Ankylosing Spondylitis, Acute Gout, Acute Musculo-Skeletal Disorders such as Periarthritis (for example frozen shoulder), Tendinitis, Tenosynovitis and Bursitis, other painful conditions resulting from; Trauma, including Fracture, low Back Pain, Sprains, strains and dislocation, orthopedic, dental and minor surgery.
  • Dosage

    Dose must be taken according to the doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult dose: Extended release: 100mg once daily; may be increased to 100mg after every 12 hours Use the lowest effective dose of Diclofenac sodium for the shortest duration necessary to control symptoms. Usual recommended dose is 75mg- 150mg daily in two or three divided doses. The maximum recommended daily dose is 150mg.
  • In case of Overdose

    Consult your doctor for management of overdose. Overdose can cause symptoms such as headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, diarrhea, dizziness, disorientation, excitation, coma, drowsiness, sinnitus, fainting or convulsions. In the case of significant poisoning acute renal failure and liver damage are possible. Supportive measures and symptomatic treatment should be given for complications such as hypotension, renal failure, convulsions, gastrointestinal disorder, and respiratory depression. Activated charcoal may be considered after ingestion of a potentially toxic overdose, and gastric decontamination (e.g., vomiting, gastric lavage) after ingestion of a potentially life threatening overdose.
  • Missed Dose

    In case you missed any dose, take the next dose as soon as you remember, but don't double your next dose to compensate for the missed one.
  • How To Use

    Take this medicine with food to avoid the risks of gastro-intestinal bleeding.
  • When Not to Use

    Diclofenac sodium is contraindicated in patients with hypersensitivity to the active substance or any of the excipients, gastric or intestinal ulcer, bleeding or perforation, history of gastrointestinal bleeding or perforation relating to previous NSAID therapy, severe hepatic, renal or cardiac failure. Diclofenac sodium should not be given to patients with the aspirin triad.
  • Side Effects

    Headache dizziness vertigo nausea vomiting diarrhea dyspepsia abdominal pain flatulence anorexia elevated serum transaminases rash Hypersensitivity anaphylactic and anaphylactoid reactions (including hypotension and shock) somnolence tiredness asthma (including dyspnea) gastritis gastrointestinal hemorrhage hematemesis diarrhea hemorrhagic melaena gastrointestinal ulcer with or without bleeding or perforation (sometimes fatal particularly in the elderly) hepatitis jaundice liver disorder urticaria edema
  • Precautions & Warnings

    Ulceration and bleeding may occur even in the absence of previous GI tract symptoms. NSAIDs should be prescribed with extreme caution in those with a prior history of ulcer disease or gastrointestinal bleeding. Special care should be taken in treating this population in elderly people to avoid fatal Gastro-intestinal events. To minimize the potential risk for an adverse Gl event, the lowest effective dose should be used for the shortest possible duration. Treatment should be discontinued if clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur (e.g., eosinophilia, rash, etc.). It can cross placenta, can cause birth defects and miscarriage due to cyclooxygenase-2 inhibition interfering with implantation. So its use must be monitored by registered medical practitioners.
  • Storage/Disposal

    Store at 25°C. Protect from sunlight and moisture.

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