Mefnac (250mg) 100 Tablets

Mefenamic acid, a non-steroidal anti-inflammatory drug (NSAID), exerts its mechanism of action primarily through the inhibition of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes play a crucial role in the synthesis of prostaglandins, which are involved in mediating inflammation, pain, and fever. By blocking the action of COX enzymes, mefenamic acid reduces the production of prostaglandins, thereby alleviating pain and inflammation. It inhibits the formation of prostaglandin precursors, particularly arachidonic acid, by targeting COX enzymes at the site of inflammation. This action disrupts the inflammatory cascade, leading to decreased pain, swelling, and discomfort associated with various conditions. Additionally, mefenamic acid may have some inhibitory effects on other inflammatory mediators, contributing to its overall analgesic and anti-inflammatory properties.

Nonsteroidal anti-inflammatory drug (NSAID)

Tablet

The following are the uses of Mefenamic Acid 250mg Tablet:

• Used for relieving period pain and discomfort.
• Used to reduce inflammation and fever associated with menstrual cramps.
• Used for managing mild to moderate pain, including headaches, toothaches, and post-operative pain.
• Used to treat pain and inflammation caused by muscle injuries or arthritis.
• Used for reducing discomfort during certain medical procedures.
• Used to manage pain and inflammation in conditions like dysmenorrhea and endometriosis.
• Used as an alternative to other non-steroidal anti-inflammatory drugs (NSAIDs) when prescribed by a doctor.
• Used to provide temporary relief from acute pain and inflammation.

Follow these dosage instructions:

• Take as per doctor's Prescription.
• Take one tablet per day as your doctor suggests.
• Your doctor will determine the treatment length based on your symptom severity.

In the case of an overdose of Mefenamic Acid 250mg Tablets, several symptoms may occur. These can include nausea, vomiting, stomach pain, and in severe cases, kidney problems or even failure. It is important to note that an overdose may also lead to rapid and shallow breathing, dizziness, and a feeling of tiredness or weakness. Prompt medical attention is necessary to manage these symptoms effectively and prevent potential long-term health complications.

In the case of a missed dose of Mefenamic Acid 250mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is generally recommended to take the medication with food to minimize stomach upset, but if you miss a dose, you can take it without food if needed. Consult your healthcare professional if you frequently miss doses or are unsure about how to manage missed doses.

To take Mefenamic Acid 250mg Tablet, swallow the tablet whole with a full glass of water, preferably with or after a meal, following the dosage instructions provided by your healthcare professional, typically one tablet every 6 to 8 hours as needed for pain relief, but not exceeding the maximum daily dosage recommended by your doctor.

Following are the conditions or circumstances when Mefenamic Acid 250mg Tablet should not be taken:

• Must not be taken by individuals who are allergic to Mefenamic Acid or other similar non-steroidal anti-inflammatory drugs (NSAIDs).
• Contraindicated in patients with a history of severe gastrointestinal bleeding or perforation.
• Should not be used by individuals who have recently undergone coronary artery bypass graft (CABG) surgery.
• Not suitable for patients with severe kidney or liver disease.
• Avoid using it if you have a history of asthma or allergic reactions triggered by aspirin or other NSAIDs.
• Do not take it if you have a bleeding disorder or systemic lupus erythematosus.
• Contraindicated during the last trimester of pregnancy.

The side effects of Mefenamic Acid 250mg Tablet may include:

• Nausea and vomiting
• Diarrhea or constipation
• Stomach pain or cramps
• Dizziness or drowsiness
• Headache
• Skin rash or itching
• Ringing in the ears (tinnitus)
• Increased blood pressure

Following are the precautions and warnings for Mefenamic Acid 250mg Tablet:

• Avoid using Mefenamic Acid if you have a known allergy to non-steroidal anti-inflammatory drugs (NSAIDs) or any other ingredients in the tablet.
• Patients with a history of gastrointestinal bleeding or ulcers should use this medication with caution, as it may increase the risk of bleeding.
• This medication may increase blood pressure, so regular monitoring is advised, especially in patients with hypertension.
• Mefenamic Acid can cause kidney impairment; patients with a history of kidney disease should be closely monitored.
• It is not recommended for long-term use due to potential risks; consult your doctor for alternative treatments if long-term pain management is required.
• Pregnant and breastfeeding women should consult their healthcare provider before using this medication, as it may have adverse effects on the fetus and infant.
• Avoid alcohol consumption while taking Mefenamic Acid, as it may increase the risk of gastrointestinal bleeding and liver toxicity.

Following are the drug interactions for Mefenamic Acid 250mg Tablet:

• May reduce the effectiveness of oral contraceptives, so alternative contraception is recommended.
• Increased risk of bleeding when taken with anticoagulants like warfarin or antiplatelet drugs.
• Can decrease the elimination of lithium, leading to potential toxicity.
• Mefenamic acid may increase the risk of side effects when used with other NSAIDs or corticosteroids.
• Potentially serious interactions with angiotensin-converting enzyme (ACE) inhibitors, diuretics, or beta-blockers, affecting kidney function.
• May affect the action of antidiabetic drugs, increasing the risk of hypoglycemia or hyperglycemia.
• Can increase plasma levels of quinolone antibiotics, possibly enhancing their side effects.

Following are the food interactions to be aware of when taking Mefenamic Acid 250mg Tablets:

• Avoid excessive caffeine intake as it can increase the risk of side effects such as nervousness, tremors, and rapid heartbeat.
• Alcohol consumption should be minimized as it can increase the chances of gastrointestinal bleeding and liver-related issues.
• Grapefruit and grapefruit juice should be consumed sparingly as they can affect the drug's metabolism, leading to increased blood levels of Mefenamic Acid.
• Dairy products like milk and cheese might decrease the absorption of the medication, so consider separating them from medication intake.
• Avoid high-sodium foods as Mefenamic Acid can lead to sodium retention, potentially causing edema.
• Limit spicy foods as they may exacerbate gastrointestinal side effects such as stomach upset and heartburn.
• Ensure a balanced diet rich in fiber to minimize potential gastrointestinal side effects.
• Always follow healthcare provider's advice regarding dietary restrictions and medication intake.

Mefenamic Acid 250mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct sunlight and moisture. It is crucial to keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity. Avoid exposing the medication to high temperatures or humidity, as this can impact its effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult your pharmacist or local waste management guidelines for safe disposal practices. Always keep medications out of children's reach to prevent accidental ingestion.

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Following are the quick tips for Mefenamic Acid 250mg Tablet:

• Take the tablet as directed by your doctor, usually 3-4 times a day.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent dosing schedule, ideally with meals.
• Avoid taking it on an empty stomach to prevent stomach irritation.
• Inform your doctor if you have a history of stomach ulcers or bleeding disorders.
• Do not take this medication if you are allergic to mefenamic acid or similar drugs.
• Store the tablets at room temperature, away from moisture and heat.