Megace (160mg) 30 Tablets

Megestrol acetate 160mg tablets primarily act as a progestin, a synthetic hormone similar to progesterone. Its mechanism of action involves binding to and activating progesterone receptors in various tissues, particularly in the brain and pituitary gland. This activation leads to a decrease in the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus, which in turn suppresses the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. By inhibiting the release of these gonadotropins, megestrol acetate reduces ovarian stimulation, resulting in decreased estrogen production and exerting its therapeutic effects in conditions such as breast cancer and endometriosis. The drug's appetite-stimulating properties are believed to be related to its progestogenic activity, although the exact mechanism behind this effect is not fully understood.

Progestin.

Tablet

The following are the uses of megestrol acetate 160mg Tablet:

• Used for treating advanced breast cancer in postmenopausal women.
• Used to manage endometrial carcinoma, improving appetite and weight gain.
• Effective for treating anorexia, cachexia, and significant weight loss in patients with AIDS.
• Used in the treatment of advanced endometrial carcinoma.
• Helps manage anorexia, cachexia, and weight loss in patients with cancer.
• Can be utilized to treat advanced endometrial carcinoma and breast cancer.
• Provides appetite stimulation and weight gain in various conditions.

In the case of an overdose of Megestrol Acetate 160mg Tablets, individuals may experience symptoms such as nausea, vomiting, dizziness, and in severe cases, a significant drop in blood pressure. It is important to promptly contact a healthcare professional or a poison control center for guidance. They will provide specific instructions based on the individual's condition, which may include inducing vomiting or administering activated charcoal to prevent further absorption of the medication. Timely medical intervention is key to managing potential complications.

In the case of a missed dose of Megestrol Acetate 160mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, it is recommended to skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects. If you frequently miss doses, it is advisable to set reminders or use a pill organizer to help you stay on track with your medication regimen. Always consult your healthcare provider if you have any concerns or questions about missed doses.

To take Megestrol Acetate 160mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions when Megestrol Acetate 160mg Tablet should not be used:

• Should not be taken by individuals with a known allergy or hypersensitivity to megestrol acetate or any of its excipients.
• Contraindicated in patients with a history of severe liver impairment or active liver disease.
• Not recommended for individuals with a history of blood clots or conditions that increase the risk of blood clots, such as deep vein thrombosis (DVT) or pulmonary embolism.
• Should not be used in women who are pregnant or planning to become pregnant, as it may cause harm to the developing fetus.
• Contraindicated in patients with a history of estrogen-dependent tumors, such as certain types of breast cancer or endometrial cancer.
• Should not be used in individuals with uncontrolled or untreated breast or genital cancers.
• Not suitable for patients with undiagnosed vaginal bleeding or a history of stroke.
• Should be avoided in individuals with a history of heart disease or cardiovascular disorders, including recent heart attack or angina.

The side effects of Megestrol Acetate 160mg Tablet may include:

• Increased appetite
• Weight gain
• Fluid retention (edema)
• Breast tenderness
• Nausea and vomiting
• Dizziness or lightheadedness
• Weakness or fatigue
• Changes in menstrual periods

Following are the precautions and warnings for Megestrol Acetate 160mg Tablet:

• Not recommended for individuals with a known hypersensitivity or allergy to megestrol acetate or any of its excipients.
• Megestrol acetate may cause fluid retention, so patients with conditions like epilepsy, migraine, asthma, heart or kidney disease should be closely monitored.
• It can increase the risk of blood clots; caution is advised in patients with a history of blood clots or conditions that increase this risk.
• This medication may cause dizziness or drowsiness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Megestrol acetate can lead to adrenal insufficiency, and symptoms like weakness, fatigue, and weight loss should be reported to a healthcare provider.
• Long-term use may increase the risk of endometrial cancer, breast cancer, and ovarian cancer, especially in postmenopausal women. Regular monitoring is necessary.
• Not recommended for use during pregnancy as it may cause harm to the fetus. Effective contraception is advised during treatment.
• Breastfeeding women should consult their healthcare provider as megestrol acetate may pass into breast milk and harm the nursing infant.

Following are the drug interactions for Megestrol Acetate 160mg Tablet:

• It can increase the effects of anticoagulants like warfarin, requiring close monitoring of blood clotting time.
• Concomitant use with cytochrome P450 3A4 (CYP3A4) inducers (e.g., rifampin, carbamazepine) may reduce the effectiveness of megestrol acetate.
• Megestrol acetate may decrease the effectiveness of CYP3A4 substrates (e.g., certain anti-seizure medications, immunosuppressants) due to enzyme induction.
• Caution is advised when combining with medications that affect the central nervous system, as it may increase sedation and drowsiness.
• The effectiveness of megestrol acetate may be reduced by CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin), requiring dose adjustments.
• It can increase blood sugar levels, so monitoring is necessary when used with antidiabetic medications.
• The risk of fluid retention and edema may be increased when used with nonsteroidal anti-inflammatory drugs (NSAIDs).

Following are the food interactions for Megestrol Acetate 160mg Tablet:

• Avoid excessive consumption of grapefruit and grapefruit juice as they can alter the drug's metabolism and potentially increase the risk of side effects.
• Alcohol intake should be limited or avoided as it may increase the sedative effects and cause additional drowsiness.
• High-fat meals can delay the absorption of Megestrol Acetate, so it is recommended to take the medication on an empty stomach or with a light meal.
• Caffeinated beverages such as coffee and tea may interfere with the drug's effectiveness, so reducing caffeine intake is advisable.
• Avoid herbal supplements like St. John's Wort, as they can affect the drug's metabolism and potentially reduce its efficacy.
• Consuming a balanced diet rich in nutrients is essential, especially since Megestrol Acetate can affect appetite and nutrient absorption.
• Always follow the dosing instructions provided by your healthcare professional, and inform them about any dietary changes or restrictions.
• This medication may cause fluid retention, so monitoring sodium intake and limiting high-sodium foods is recommended.

Megestrol acetate 160mg tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. Avoid storing the tablets in the bathroom or near heat-emitting appliances, as temperature fluctuations can impact their effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult a pharmacist or healthcare professional for guidance on proper disposal methods, and always keep medications away from children to prevent accidental consumption. It is crucial to handle and store megestrol acetate tablets with care to maintain their quality and safety.

Following are the quick tips for Megestrol Acetate 160mg Tablet:

• Consult your doctor for the right dosage based on your condition.
• Swallow the tablet whole with water; do not crush or chew.
• Take it at the same time each day to maintain consistent blood levels.
• Ensure you complete the full course as prescribed by your doctor.
• Inform your doctor about all medications you're taking to avoid interactions.
• Store in a cool, dry place, away from direct sunlight and moisture.
• Do not share this medication with others, even with similar symptoms.
• Regularly monitor your health and report any unusual symptoms to your doctor.