MEGACE IMP 40MG 120'S (MEGESTEROL)

Megestrol 40mg tablets primarily exert their effect through their interaction with progesterone receptors. This medication acts as a progestin, a synthetic form of the hormone progesterone. Upon binding to progesterone receptors in various tissues, megestrol acetate can influence multiple physiological processes. One of its key mechanisms is the stimulation of appetite and subsequent weight gain, achieved by altering the levels of neurotransmitters and hormones that regulate hunger and satiety. Additionally, it may have anti-inflammatory and immunomodulatory effects, potentially suppressing the immune system and reducing inflammation. The drug can also impact the endocrine system, influencing the production and release of certain hormones, which may contribute to its therapeutic benefits in specific medical conditions.

Megestrol is a progestin.

Tablet

The following are the uses of MEGESTROL 40MG Tablet:

• Used for treating severe appetite and weight loss due to AIDS.
• Used to manage advanced breast and endometrial cancers.
• Used to stimulate appetite and promote weight gain in patients with significant weight loss due to medical conditions.
• Used to treat anorexia and cachexia, helping patients regain appetite and improve nutritional status.
• Used to manage various types of cancer by slowing the growth of cancer cells.
• Used to support patients undergoing chemotherapy to reduce side effects and improve quality of life.
• Used as an adjunct therapy to enhance the effectiveness of other cancer treatments.

In the case of an overdose of MEGESTROL 40MG Tablets, individuals may experience symptoms such as nausea, vomiting, and diarrhea. The severity of these symptoms can vary depending on the amount ingested. It is important to seek medical advice promptly if an overdose is suspected, as healthcare professionals can provide guidance on managing any adverse effects and ensuring appropriate treatment. Prompt action can help minimize potential risks and ensure the well-being of the individual.

In the case of a missed dose of MEGESTROL 40MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or provide alternative instructions to ensure the treatment remains effective.

To take MEGESTROL 40MG Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, and do not crush or chew the tablet.

Following are the conditions when Megestrol 40mg Tablet should not be used:

• Must not be used in individuals with a known allergy to megestrol acetate or any other similar medications.
• Not suitable for women who are pregnant or planning to become pregnant, as it can cause harm to the developing fetus.
• Should not be used in women who are breastfeeding, as it can pass into breast milk and may harm the nursing infant.
• Contraindicated in patients with a history of blood clots or active thrombophlebitis, as it may increase the risk of blood clots.
• Not recommended for individuals with severe liver impairment or liver disease, as it is primarily metabolized by the liver.
• Should be avoided in patients with a history of hormone-sensitive cancers, such as breast or uterine cancer.
• Must not be used to treat unexplained weight loss without first ruling out other potential causes.

The side effects of MEGESTROL 40MG Tablet may include:

• Increased appetite
• Fluid retention, causing swelling in your arms, legs, or feet
• Indigestion or heartburn
• Diarrhea or constipation
• Nausea and vomiting
• Dizziness or weakness
• Skin rashes or itching
• Changes in menstrual periods

Following are the precautions and warnings for MEGESTROL 40MG Tablet:

• This medication is not meant for weight gain in patients with advanced cancer. It is not a substitute for a balanced diet and proper medical care.
• Patients with a history of blood clots, stroke, or heart attack should exercise caution as this drug may increase the risk of these conditions.
• Megestrol can cause changes in blood sugar levels, so diabetic patients must monitor their blood sugar regularly and adjust their diabetes medication as needed.
• It may suppress the body's immune response, making patients more susceptible to infections. Promptly report any signs of infection to your doctor.
• Not recommended for use during pregnancy as it may cause harm to the fetus. Effective contraception is advised while taking this medication.
• Can cause dizziness and drowsiness. Avoid driving or operating heavy machinery until you know how this medication affects you.
• This medication may cause fluid retention, so patients with conditions like heart failure or kidney impairment should be closely monitored.
• Long-term use of megestrol may increase the risk of adrenal gland problems, and sudden discontinuation can lead to adrenal insufficiency. Do not stop taking it without consulting your doctor.

Following are the drug interactions for MEGESTROL 40MG Tablet:

• MEGESTROL can increase the blood levels of cyclosporine, leading to potential toxicity.
• Concomitant use with antiretroviral protease inhibitors may reduce the effectiveness of both drugs.
• It can interact with anticoagulants like warfarin, possibly requiring adjustment of anticoagulant dosage.
• May increase the risk of bleeding when taken with nonsteroidal anti-inflammatory drugs (NSAIDs).
• May enhance the effects of oral hypoglycemic agents or insulin, requiring careful monitoring of blood glucose.
• Use with caution alongside drugs that affect the central nervous system, as it may increase CNS side effects.
• Can increase plasma concentrations of bupropion, requiring dosage adjustments.
• May reduce the effectiveness of hormonal contraceptives, requiring additional contraceptive measures.

Following are the food interactions for Megestrol 40mg Tablet:

• Avoid consuming grapefruit and grapefruit juice as they may interfere with the metabolism of the drug, leading to increased levels in the blood and potential side effects.
• Alcohol consumption should be limited or avoided as it can increase the risk of dizziness, drowsiness, and other central nervous system side effects associated with Megestrol.
• High-fat meals can slightly decrease the absorption of Megestrol, so it is best to take the medication on an empty stomach or with a low-fat meal for optimal absorption.
• Avoid herbal supplements like St. John's Wort as they may affect the drug's metabolism and increase the risk of side effects.
• Vitamin E supplements may interfere with the absorption of Megestrol, so it is advisable to separate their intake by a few hours.
• Megestrol may cause increased appetite and weight gain, so a balanced diet with controlled calorie intake is recommended to manage these effects.
• Avoid high-sodium foods as Megestrol may cause sodium retention, leading to fluid build-up and swelling.
• Consult your healthcare provider for specific dietary recommendations, especially if you have diabetes or other conditions affected by diet.

Megestrol 40MG Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposure to heat, including direct sunlight, stoves, or radiators, as it can degrade the medication. Always check the expiration date, and dispose of any unused tablets properly; do not flush or pour them into drainage systems. Consult a pharmacist or healthcare provider for guidance on safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Megestrol 40mg Tablet:

• Take the tablet as directed by your doctor, typically once or twice daily.
• Swallow the tablet whole with a full glass of water; do not crush or chew.
• You can take it with or without food, but be consistent with your choice.
• Maintain a consistent schedule for taking the medication for best results.
• Avoid missing doses; if you miss one, take it as soon as you remember, unless it's almost time for the next dose.
• Inform your doctor if you have a history of liver or kidney problems before taking this medication.
• Store the tablets at room temperature, away from moisture and direct sunlight.