Megadip (5mg) 20 Tablets

The medication belongs to the class of antianginal agents and antihypertensive, specifically a calcium channel blocker of the dihydropyridine type. Amlodipine functions as a dihydropyridine calcium antagonist by inhibiting the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscles. This action results in a reduction of peripheral vascular resistance, leading to a decrease in blood pressure.

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Calcium channel blocker

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Tablet

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Used for:

• Treatment of symptomatic chronic stable angina

• Treatment of confirmed or suspected vasospastic angina

• Management of hypertension in adults and children ≥6 years of age

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Dose must be taken according to doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Children dose; <6 years: Oral initial dose is; 0.1 mg/kg/dose once daily; maximum daily dose is 0.6 mg/kg/day or 5 mg/day. Children ≥6 years and Adolescents: Oral initial dose is; 2.5 mg once daily; maximum daily dose is 10 mg/day. Adult dose: Initial starting dose is 2.5mg once daily, then 5-10mg once daily, maximum daily dose is 10mg once daily.

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Consult your doctor in case of overdose, as it may cause hypotension.

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In case you missed any dose, take the next dose as soon as you remember, but don't double your next dose to compensate for the missed one.

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Take it orally with your doctor’s instructions.

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Hypersensitivity to amlodipine or any component of the formulation occurs, then do not use. Do not use amlodipine during breastfeeding.

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Unraveling the side effects lurking behind this product are the following:

• Acute hypotension upon initiation is unlikely due to the gradual onset of action.

• Blood pressure must be lowered at a rate appropriate for the patient's clinical condition.

• Use with caution in patients with hepatic impairment.

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Use with caution in Patient with:

•  CHF
•  Hepatic impairment
•  Children and elderly
• Pregnancy and lactation

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The drug interactions with amlodipine include:

• CYP3A4 Inhibitors (e.g., ketoconazole) – Can increase amlodipine levels, increasing the risk of side effects.
• CYP3A4 Inducers (e.g., rifampin) – Can decrease amlodipine levels, reducing its effectiveness.
• Grapefruit Juice – Can increase amlodipine levels, increasing the risk of side effects.
• Simvastatin – May increase the risk of simvastatin-related side effects.
• Other Antihypertensives (e.g., beta-blockers) – Can have additive effects on blood pressure.
• NSAIDs – May reduce the antihypertensive effect of amlodipine.

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Increased bioavailability with grapefruit or grapefruit juice. Decreased plasma concentration with St John's wort.

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Store between 15-30°C. Protect from light.

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Amlodipine. Blood pressure lowering agents like

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