MELA DERM PLUS CREAM

The mechanism of action of Alpha-Arbutin and Kojic Acid in the cream primarily involves inhibiting melanin production. Alpha-Arbutin works by suppressing tyrosinase activity, a key enzyme in melanin synthesis, thus reducing the formation of melanin pigments. This inhibition occurs through the competition of Alpha-Arbutin with L-tyrosine for the active site of tyrosinase. Kojic acid, on the other hand, acts as a chelating agent, forming a complex with copper ions that are essential for the functioning of tyrosinase, thereby reducing the enzyme's activity and subsequent melanin production. The combined effect of these two ingredients results in a synergistic skin-lightening action, addressing hyperpigmentation and promoting a more even skin tone.

Alpha-Arbutin, kojic acid 0.06

Tyrosinase inhibitor

Cream

The following are the uses of Alpha-Arbutin, kojic acid 0.06 Cream:

• Used for lightening dark spots and hyperpigmentation caused by sun damage, acne scars, or melasma.
• Used to even out skin tone and improve overall skin radiance.
• Used for reducing the appearance of age spots and promoting a brighter complexion.
• Used for inhibiting melanin production, resulting in a more uniform skin color.
• Used to enhance the effectiveness of other skincare ingredients when combined in a formulation.
• Used for providing antioxidant benefits, protecting the skin from environmental damage.
• Used for its gentle yet effective approach to skin brightening, suitable for most skin types.

In the case of an overdose of Alpha-Arbutin and kojic acid 0.06% Cream, it is important to recognize the potential symptoms. These may include skin irritation, redness, and increased sensitivity. If you suspect an overdose, promptly wash the affected area with mild soap and water. Seek medical advice for further guidance, especially if symptoms persist or worsen. It is crucial to use this medication as directed by your healthcare provider to prevent adverse effects.

In the case of a missed dose of Alpha-Arbutin and kojic acid 0.06% Cream, it is recommended to apply the cream as soon as you remember. However, if it's almost time for your next scheduled application, skip the missed dose and continue with your regular schedule. Do not apply extra cream to make up for the missed dose. If you miss multiple doses, consult your healthcare provider for guidance on how to resume the treatment and ensure you're using the product effectively and safely.

To apply Alpha-Arbutin, kojic acid 0.06% Cream, gently cleanse and dry the affected area, then apply a thin layer of the cream, typically twice a day or as directed by your healthcare provider, and massage it into the skin until it is completely absorbed.

Following are the conditions or circumstances when Alpha-Arbutin and Kojic Acid 0.06% Cream should be avoided:

• Avoid using this cream if you have a known allergy or sensitivity to Alpha-Arbutin, Kojic Acid, or any other ingredients in the formulation.
• Do not use on open wounds, cuts, or severely damaged skin.
• Not suitable for individuals with extreme sun sensitivity or those who have recently undergone laser treatments or chemical peels.
• Avoid using on skin affected by eczema, psoriasis, or severe skin inflammation.
• Do not use on children's skin without medical advice.
• Discontinue use if you experience severe skin irritation, itching, or burning sensation after application.
• Avoid using this cream if you are pregnant or breastfeeding, unless advised by a healthcare professional.
• Do not use this cream in combination with other skin lightening agents without medical supervision.

The possible side effects of Alpha-Arbutin, kojic acid 0.06 Cream may include:

• Skin irritation or redness at the application site
• Itching or stinging sensation
• Dryness or flakiness of the skin
• Temporary darkening or lightening of the skin
• Mild burning or tingling
• Increased skin sensitivity to sunlight
• Allergic reactions (rarely), such as rash, swelling, or difficulty breathing.

Following are the precautions and warnings for Alpha-Arbutin, kojic acid 0.06 Cream:

• Avoid contact with eyes, mouth, and open wounds. In case of accidental contact, rinse thoroughly with water.
• Perform a patch test on a small area of skin before applying to larger areas to check for any allergic reactions.
• Discontinue use if irritation, redness, or itching occurs and consult a healthcare professional.
• Do not use on broken or damaged skin.
• Keep out of reach of children and pets. Store in a cool, dry place away from direct sunlight.
• This product may increase sun sensitivity, so limit sun exposure and use sunscreen when outdoors.
• Individuals with sensitive skin should exercise caution and monitor for any adverse reactions.
• Do not use if you are allergic to any of the ingredients in the cream.

Following are the drug interactions for Alpha-Arbutin, kojic acid 0.06% Cream:

• Alpha-Arbutin may interact with drugs that affect melanin production, such as hydroquinone or mequinol, potentially increasing skin sensitivity.
• Topical retinoids or exfoliants can enhance the absorption of Kojic Acid, leading to increased skin irritation.
• Avoid using other topical skin lightening agents simultaneously to prevent excessive skin drying and irritation.
• Drugs that increase photosensitivity, such as certain antibiotics or anti-inflammatory medications, may intensify the sun-sensitizing effect of Kojic Acid.
• The effectiveness of Kojic Acid may be reduced when used with products containing high concentrations of antioxidants, like Vitamin C or E.
• Skin irritation may be heightened when combining Alpha-Arbutin with other AHA (Alpha Hydroxy Acids) or BHA (Beta Hydroxy Acids) exfoliants.
• Consult a pharmacist or dermatologist before using this cream with other medications to avoid potential interactions.

Following are the food interactions for Alpha-Arbutin, kojic acid 0.06 Cream:

• Citrus fruits like oranges, lemons, and limes should be consumed in moderation as they may cause mild skin irritation or sensitivity due to their acidic nature.
• Avoid excessive consumption of foods rich in Vitamin C, such as bell peppers and strawberries, as they can enhance skin sensitivity when exposed to sunlight.
• Kojic acid may interact with fermented foods like yogurt, kefir, and kombucha, potentially affecting the skin's microflora.
• Limit spicy foods containing chili peppers or hot spices, as they can temporarily increase skin redness and sensitivity.
• Avoid excessive sun exposure and consider using sunscreen, as Alpha-Arbutin can make the skin more sensitive to sunlight.
• Green tea and its extracts are generally safe, but excessive consumption might enhance the effects of Alpha-Arbutin and Kojic Acid, leading to increased skin sensitivity.
• Alcohol consumption should be minimized, as it can dehydrate the skin and reduce the effectiveness of the cream.
• Some studies suggest that foods rich in omega-3 fatty acids, like salmon and walnuts, may enhance the skin-lightening effects of Alpha-Arbutin.

Alpha-Arbutin and Kojic Acid 0.06% Cream should be stored in a cool, dry location, ideally in its original packaging, which is typically an airtight tube or jar. Maintain a room temperature environment, avoiding direct sunlight and heat sources like radiators or ovens, as these can degrade the cream's quality. To prevent contamination, ensure the container is tightly sealed after each use. Dispose of any expired or unused cream responsibly; do not flush it down the toilet or pour it into a drain. Instead, consult your local waste management guidelines or a healthcare professional for appropriate disposal methods. Keep the cream out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Alpha-Arbutin, Kojic Acid 0.06 Cream:

• Apply a thin layer to affected areas, ensuring even coverage.
• Use as directed by your dermatologist for best results.
• Wash your hands before and after application for hygiene.
• Avoid contact with eyes, mouth, and other sensitive areas.
• If irritation occurs, discontinue use and consult your doctor.
• Store in a cool, dry place, away from direct sunlight.
• Do not use on broken or irritated skin.