MELADREM CREAM 15G

The mechanism of action of Alpha-Arbutin and Kojic Acid in the 0.03% cream formulation primarily revolves around their ability to inhibit melanin production. Alpha-Arbutin works by inhibiting the enzyme tyrosinase, which is crucial for the synthesis of melanin. By blocking the activity of tyrosinase, Alpha-Arbutin reduces the formation of melanin pigments, resulting in a skin-lightening effect. Kojic Acid, on the other hand, acts through multiple mechanisms. It directly chelates copper ions required for the activity of tyrosinase, thus inhibiting melanin production. Additionally, Kojic Acid can scavenge free radicals and exhibit antioxidant properties, contributing to its skin-brightening effects. Together, these two active ingredients synergistically target melanin synthesis, leading to a more even skin tone and reduced hyperpigmentation.

Alpha-Arbutin, kojic acid 0.03

Whitening agents.

Cream

The following are the uses of Alpha-Arbutin, kojic acid 0.03 Cream:

• Used for reducing the appearance of dark spots, age spots, and hyperpigmentation.
• Used for skin brightening and evening out skin tone.
• Used to improve overall skin radiance and clarity.
• Used for treating melasma and sun-induced skin discoloration.
• Used for inhibiting tyrosinase activity, preventing excess melanin production.
• Used to enhance the effectiveness of other skincare actives in a routine.
• Used for maintaining long-term skin luminosity and a youthful complexion.
• Used in combination with other ingredients for a comprehensive skincare approach.

In the case of an overdose of Alpha-Arbutin and kojic acid 0.03 Cream, it is important to remain calm and take appropriate actions. Although rare, an overdose may lead to skin irritation, redness, or increased sensitivity. If a large quantity has been ingested, it could potentially cause gastrointestinal discomfort. Contact a healthcare professional or poison control center for guidance, as they can provide specific advice based on the individual's condition.

In the case of a missed dose of Alpha-Arbutin and kojic acid 0.03 Cream, it is generally recommended to apply the cream as soon as you remember. However, if it's almost time for your next scheduled application, skip the missed dose and continue with your regular schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of skin irritation. If you frequently miss doses, consider setting reminders or using a medication tracking app to help you stay on track with your skincare routine.

To use Alpha-Arbutin, kojic acid 0.03 Cream, gently apply a thin layer to the affected area once or twice daily, or as directed by your healthcare provider, after cleansing and toning your skin.

Following are the conditions/situations to avoid when using Alpha-Arbutin and Kojic Acid 0.03% Cream:

• Do not use if you have a known allergy or sensitivity to Alpha-Arbutin, Kojic Acid, or any other ingredients in the cream.
• Avoid using on open wounds, cuts, or severely damaged skin.
• Not suitable for individuals with extreme sun sensitivity or those who are prone to severe sunburns.
• Discontinue use if you experience severe skin irritation, redness, itching, or any other adverse skin reactions.
• Avoid using the cream on skin areas where you have recently used other intense skin treatments like chemical peels or laser therapy.
• Do not use the cream if you are pregnant or breastfeeding, unless advised by a healthcare professional.
• Do not use on children or infants without medical supervision.
• Avoid using the cream if you have a history of skin conditions like eczema or dermatitis, as it may aggravate these conditions.

The side effects of Alpha-Arbutin, kojic acid 0.03 Cream may include:

• Skin irritation or redness at the application site
• Itching or stinging sensation
• Dryness or flakiness of the skin
• Mild peeling or exfoliation
• Increased sensitivity to sunlight
• Darkening of the skin (rare)
• Allergic reactions (skin rash, swelling, or difficulty breathing)

Following are the precautions and warnings for Alpha-Arbutin and Kojic Acid 0.03 Cream:

• Avoid contact with eyes and mucous membranes. In case of accidental contact, rinse thoroughly with water.
• This cream may cause skin irritation in some individuals; perform a patch test on a small area of skin before regular use.
• Do not use on broken or damaged skin, and discontinue use if irritation or redness occurs.
• Kojic acid may increase skin sensitivity to sunlight; limit sun exposure and use sunscreen when outdoors.
• Alpha-Arbutin may cause skin sensitivity; be cautious when combining with other skin-sensitizing ingredients.
• Not recommended for use in pregnant or breastfeeding women due to limited safety data.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.
• Consult a healthcare professional if you have any underlying skin conditions or concerns before using this product.

Following are the drug interactions for Alpha-Arbutin, kojic acid 0.03% Cream:

• Alpha-Arbutin may interact with drugs metabolized by the liver, potentially affecting the breakdown of these medications.
• Kojic acid can enhance the skin's sensitivity to sunlight, so avoid using photosensitizing drugs concurrently.
• The cream may increase the skin's sensitivity; exercise caution when using with other topical agents.
• Avoid using with hydroquinone-containing products, as it may lead to excessive skin lightening.
• Retinoids and Alpha-Arbutin can cause increased skin irritation when used together.
• Kojic acid can potentially interact with antioxidants, affecting their stability and efficacy.
• Combining with other skin-lightening agents may increase the risk of skin irritation and adverse effects.
• Topical corticosteroids and this cream might reduce the effectiveness of each other.

Following are the food interactions for Alpha-Arbutin and Kojic Acid 0.03 Cream:

• Avoid excessive citrus fruit consumption, as these fruits can increase skin sensitivity to sunlight, potentially reducing the effectiveness of Kojic Acid.
• Limit or avoid alcohol-containing skincare products, as alcohol can irritate the skin and counteract the benefits of Alpha-Arbutin.
• Avoid foods rich in Vitamin C supplements during the day when using Kojic Acid, as they can cause photosensitivity.
• Consuming foods with high antioxidant properties, like berries and dark chocolate, can support the skin's health and enhance the effects of Alpha-Arbutin.
• Kojic Acid may be less effective when exposed to foods with high acidity, such as tomatoes and vinegar.
• Garlic and onion, when consumed in large amounts, may interfere with the skin's sensitivity, affecting the results of the cream.
• Avoid excessive sun exposure and use sunscreen, as Kojic Acid can make your skin more sensitive to sunlight.

The proper storage and disposal of Alpha-Arbutin, kojic acid 0.03 Cream is crucial. Store the cream in a cool, dry place, ensuring it is tightly sealed in its original container to maintain its integrity and prevent contamination. Keep it away from direct sunlight, heat sources, and moisture, as temperature fluctuations can impact its effectiveness. Always check the expiration date, and never use the cream beyond this date. For disposal, do not flush or pour the cream down the drain; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods to minimize environmental impact. Keep the cream securely stored, out of children's reach, to prevent accidental exposure.

Following are the quick tips for Alpha-Arbutin, Kojic Acid 0.03 Cream:

• Apply a thin layer to affected areas as directed by your dermatologist.
• Use it on clean, dry skin for better absorption.
• Gently massage the cream into the skin until it is fully absorbed.
• Avoid contact with eyes and mucous membranes.
• Use sunscreen daily to protect your skin from UV damage.
• Discontinue use if irritation occurs and consult your doctor.
• Store the cream in a cool, dry place, away from direct sunlight.
• Do not use on broken or irritated skin.