Melide (100mg) 20 Tablets

Nimesulide 100mg Tablet primarily exerts its anti-inflammatory, analgesic, and antipyretic effects through selective inhibition of cyclooxygenase-2 (COX-2) enzyme. By blocking COX-2, nimesulide interferes with the production of prostaglandins, which are key mediators of pain, inflammation, and fever. This mechanism is responsible for the reduction of pain and inflammation associated with various conditions. Nimesulide's selectivity for COX-2 is believed to contribute to its therapeutic effects while potentially reducing the gastrointestinal side effects associated with non-selective nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit both COX-1 and COX-2 enzymes.

Non-steroidal anti-inflammatory drug (NSAID).

Tablet

The following are the uses of Nimesulide 100mg Tablet:

• Used for relieving pain and reducing inflammation, especially in conditions like osteoarthritis and rheumatoid arthritis.
• Used for managing acute pain, including post-operative pain, dental pain, and pain due to injuries.
• Used for treating pain and discomfort associated with menstrual cramps and dysmenorrhea.
• Used for reducing fever and managing pain in conditions such as flu and other viral infections.
• Used for alleviating pain and inflammation in soft tissue injuries and sprains.
• Used for providing symptomatic relief in migraine and tension headaches.
• Used for controlling pain and inflammation in ankylosing spondylitis and other inflammatory joint disorders.
• Used for short-term pain management in various musculoskeletal conditions.

In the case of an overdose of Nimesulide 100mg Tablets, symptoms may include nausea, vomiting, abdominal pain, and in severe cases, liver damage. Promptly seek medical assistance and inform the healthcare provider about the quantity ingested. Treatment involves supportive care and monitoring of vital signs, with potential interventions to address liver function. Quick action is vital to mitigate the risks associated with this overdose, ensuring appropriate medical management.

In the case of a missed dose of Nimesulide 100mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss several doses, contact your healthcare provider for advice on how to safely resume your medication regimen without affecting the treatment's effectiveness. It is generally recommended to take the missed dose within a 1-2 hour window after the intended time.

To take Nimesulide 100mg Tablet, swallow the tablet whole with a glass of water, preferably with or after food, following the dosage instructions provided by your healthcare professional, typically once or twice a day, or as prescribed based on your medical condition.

Following are the conditions/situations when Nimesulide 100mg Tablet should not be taken:

• Avoid in patients with known allergies or hypersensitivity to Nimesulide or any other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
• Not recommended for individuals with active gastric or intestinal ulcers.
• Contraindicated in patients with severe heart failure or heart disease.
• Should not be used in individuals with severe kidney or liver impairment.
• Not suitable for pregnant women, especially during the third trimester.
• Avoid in breastfeeding mothers.
• Do not administer to children below 12 years of age.
• Should not be used by individuals with a history of asthma or other respiratory disorders triggered by NSAIDs.
• Contraindicated in patients with bleeding disorders or those on anticoagulant therapy.

The side effects of Nimesulide 100mg Tablet may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Headache
• Dizziness
• Skin rashes or itching
• Increased liver enzymes (liver-related issues)
• Allergic reactions (in rare cases)

Following are the precautions and warnings for Nimesulide 100mg Tablet:

• This medication should not be used in patients with a known allergy or hypersensitivity to Nimesulide or any other ingredients in the tablet.
• Patients with a history of gastrointestinal bleeding, peptic ulcers, or other gastrointestinal disorders should use this medication with caution as it may increase the risk of bleeding.
• Nimesulide may affect liver function, so regular monitoring is necessary, especially in long-term treatment. Discontinue use if liver enzymes become elevated.
• Elderly patients may be more susceptible to side effects, particularly gastrointestinal bleeding and kidney problems. Close monitoring is recommended.
• Patients with kidney disease should use this medication with caution as it is primarily eliminated through the kidneys. Dosage adjustments might be required.
• Nimesulide may increase the risk of cardiovascular events, including heart attack and stroke. Patients with cardiovascular disease or risk factors should use it with caution.
• This medication is not recommended for use in children and adolescents under 18 years of age due to the potential risk of liver-related adverse effects.
• Always inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Nimesulide 100mg Tablet:

• It may interact with anticoagulants (blood thinners) like warfarin, potentially increasing the risk of bleeding. Regular monitoring is advised.
• Nimesulide can increase the concentration of lithium in the blood, leading to increased side effects. Lithium levels should be monitored.
• Concomitant use with other non-steroidal anti-inflammatory drugs (NSAIDs) may increase the likelihood of gastrointestinal side effects and bleeding.
• The risk of kidney damage is heightened when combined with diuretics, angiotensin-converting enzyme (ACE) inhibitors, or angiotensin receptor blockers (ARBs).
• Methotrexate levels can be increased by Nimesulide, leading to enhanced toxicity. Close monitoring is required.
• Combining Nimesulide with corticosteroids may increase the risk of gastrointestinal bleeding and ulceration.
• Antihypertensive effects of beta-blockers might be reduced by Nimesulide, potentially affecting blood pressure control.

Following are the food interactions for Nimesulide 100mg Tablet:

• Avoid excessive alcohol consumption while taking this medication as it may increase the risk of gastrointestinal bleeding and liver toxicity.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit liver enzymes, potentially leading to increased Nimesulide levels in the body.
• Avoid high-fat meals as they may delay the absorption of Nimesulide, affecting its onset of action.
• Dairy products and antacids containing calcium, aluminum, or magnesium may reduce the absorption of Nimesulide; consider separating their intake by a few hours.
• Caffeine intake should be monitored as Nimesulide may enhance its effects, potentially causing nervousness or insomnia.
• Limit the consumption of spicy foods as Nimesulide may increase gastric irritation, exacerbating gastrointestinal side effects.
• Stay hydrated and maintain a balanced diet to support overall health while taking this medication.

Nimesulide 100mg Tablets should be stored in a cool and dry place, preferably at room temperature below 25°C (77°F). Keep the tablets in their original container, tightly sealed, to protect them from moisture and light. Avoid storing them in the bathroom or kitchen, as these areas may have high humidity and temperature fluctuations. It is crucial to keep this medication out of the reach of children and pets to prevent accidental ingestion. Do not use the tablets if the packaging is damaged or shows signs of tampering. Dispose of any unused or expired medication responsibly by following local guidelines or consulting a pharmacist. Never throw medications into the trash or flush them down the toilet unless advised to do so, as these methods can harm the environment.

Following are the quick tips for Nimesulide 100mg Tablet:

• Consult a doctor before use, especially if you have a history of stomach ulcers or kidney problems.
• Take the tablet with or after food to minimize stomach irritation.
• Do not exceed the prescribed dosage and duration of treatment.
• Avoid alcohol consumption while taking this medication.
• If you experience any allergic reactions or severe side effects, seek medical attention immediately.
• Store the tablets in a cool, dry place, away from direct sunlight.
• Do not share this medication with others, even if their symptoms appear similar.