MELLERIL 100MG TAB

Thioridazine 100MG Tablet primarily exerts its effects through its action on the central nervous system, particularly by blocking specific types of dopamine receptors in the brain. It is classified as a typical antipsychotic, and its mechanism of action involves a strong antagonism of D2 dopamine receptors, which helps to reduce the positive symptoms of schizophrenia, such as hallucinations and delusions. Thioridazine also exhibits alpha-adrenergic, anticholinergic, and antihistaminic properties, which contribute to its side effect profile but are not the primary mechanism through which it achieves its therapeutic effects. By selectively blocking dopamine receptors, thioridazine helps to regulate dopamine-mediated neurotransmission, thereby alleviating psychotic symptoms and stabilizing mood in patients with schizophrenia and other psychotic disorders.

Phenothiazine antipsychotic

Tablet

The following are the uses of Thioridazine 100MG Tablet:

• Used for treating schizophrenia and other psychotic disorders, helping patients manage hallucinations and delusions.
• Used for controlling severe behavior problems in patients with Alzheimer's disease, reducing aggression and agitation.
• Used for managing severe nausea and vomiting, especially in cancer patients undergoing chemotherapy.
• Used for alleviating severe anxiety and panic attacks, providing quick relief.
• Used for supporting detoxification in individuals with substance abuse disorders.
• Used for treating severe itching caused by various skin conditions.
• Used for managing severe chronic pain, especially when other pain medications are ineffective.

In the case of an overdose of Thioridazine 100MG Tablets, it is important to recognize the potential severity of this situation. Symptoms may include severe drowsiness, confusion, uncontrolled muscle movements, and changes in heart rate and blood pressure. If an overdose is suspected, seek medical advice immediately. Prompt action is essential, as the effects can be life-threatening, particularly in children or individuals with pre-existing health conditions. Time is of the essence in such cases.

In the case of a missed dose of Thioridazine 100MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking someone to help you remember to take your medication as prescribed. It is crucial to maintain consistency in taking your medication for optimal therapeutic benefits.

To take Thioridazine 100MG Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically once or twice daily as prescribed.

The following are the circumstances when Thioridazine 100MG Tablet should not be administered:

• Avoid use in patients with a known hypersensitivity or allergy to Thioridazine or other similar medications.
• Not suitable for individuals with severe central nervous system depression or those in a comatose state.
• Contraindicated in patients with known heart rhythm disorders or a prolonged QT interval.
• Should not be used in patients with severe liver or kidney disease.
• Avoid use in individuals with a history of seizures or epilepsy.
• Not recommended for elderly patients with dementia, due to the increased risk of serious side effects.
• Contraindicated in patients with pheochromocytoma.
• Should not be used in combination with other medications that prolong the QT interval.

The side effects of Thioridazine 100MG Tablet may include:

• Dizziness or lightheadedness
• Dry mouth
• Blurred vision
• Constipation
• Muscle stiffness or tremors
• Skin rashes or itching
• Sedation or drowsiness
• Rapid or irregular heartbeat

Following are the precautions and warnings for Thioridazine 100MG Tablet:

• Do not use this medication if you have a known allergy or sensitivity to Thioridazine or any of its excipients.
• Thioridazine may cause QT prolongation, so it should be used with caution in patients with a history of heart disease, low potassium or magnesium levels, or those taking other medications that can affect heart rhythm.
• Regular monitoring of heart function and ECGs is recommended during treatment.
• This medication can cause drowsiness and dizziness, so patients should avoid driving or operating heavy machinery until they know how it affects them.
• Thioridazine may increase the risk of developing tardive dyskinesia, a serious movement disorder. Any unusual movements should be reported to the doctor immediately.
• Elderly patients may be more susceptible to side effects, especially those related to the nervous system and heart.
• Use with caution in patients with liver or kidney disease, as dosage adjustments may be necessary.
• Inform your doctor about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Thioridazine 100MG Tablet:

• Thioridazine can interact with other antipsychotic medications, such as chlorpromazine and haloperidol, leading to increased risk of adverse effects and prolonged QTc interval.
• Drugs that prolong the QT interval (e.g., amiodarone, sotalol) should be avoided as they can increase the risk of cardiac arrhythmias when combined with thioridazine.
• Antidepressants like fluoxetine and paroxetine can inhibit the metabolism of thioridazine, resulting in elevated thioridazine levels and increased side effects.
• Thioridazine may enhance the effects of CNS depressants, including opioids, benzodiazepines, and alcohol, leading to excessive sedation and respiratory depression.
• The effectiveness of levodopa in treating Parkinson's disease may be reduced by thioridazine, and their combined use can lead to worsened parkinsonism.
• Anticonvulsants like phenytoin and carbamazepine can lower thioridazine levels, potentially reducing its therapeutic effect.
• Co-administration with lithium may increase the risk of neuroleptic malignant syndrome, a life-threatening condition.

Following are the food interactions for Thioridazine 100MG Tablet:

• Alcohol consumption should be avoided as it can enhance the sedative effects of Thioridazine, leading to increased dizziness and drowsiness.
• Grapefruit and grapefruit juice are to be avoided as they can increase the concentration of Thioridazine in the blood, potentially leading to higher side effect risks.
• High-fat meals can slightly decrease the absorption of Thioridazine, so it's best to take the medication on an empty stomach or with a light meal.
• Dairy products may interfere with the absorption of Thioridazine; consider separating dairy intake from medication by a few hours.
• Foods rich in tyramine, like aged cheeses, cured meats, and certain types of beer, should be avoided as they can interact with Thioridazine and lead to a dangerous spike in blood pressure.
• Avoid caffeine-rich foods and beverages as they can exacerbate the nervous system side effects of Thioridazine, causing increased anxiety, restlessness, and sleep disturbances.
• Always ensure you are well-hydrated when taking Thioridazine to aid in the medication's absorption and reduce the risk of dehydration-related side effects.
• Consult your healthcare provider for personalized advice on dietary adjustments, especially if you have a history of cardiovascular issues or are taking other medications.

Thioridazine 100MG Tablets should be stored in a secure and dry location, preferably at room temperature, away from direct sunlight, moisture, and heat sources like ovens or radiators. It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. When disposing of unused or expired tablets, do not flush them or pour them down the drain. Instead, consult your pharmacist or local waste management guidelines for safe disposal practices. Ensure that the medication is kept away from children to prevent accidental consumption, as it should be handled with the same caution as when it was in use. Regularly check the expiration date on the packaging to ensure the medication's effectiveness and safety.

Following are the quick tips for Thioridazine 100MG Tablet:

• Start with a low dose and gradually increase as directed by your doctor.
• Take the tablet with a full glass of water, preferably at the same time daily.
• Ensure you are well-hydrated before and after taking the medication.
• Avoid alcohol consumption while on this medication.
• Do not stop taking the tablet abruptly; follow your doctor's instructions for tapering.
• Inform your doctor about all medications you are taking to avoid potential interactions.
• Regularly monitor your blood pressure, heart rate, and liver function while on this medication.