MELLERIL 10MG TAB

Thioridazine, a 10MG tablet, acts as a potent antagonist of dopamine D2 receptors in the brain, primarily in the mesolimbic and mesocortical pathways. Its mechanism of action involves blocking these dopamine receptors, leading to a reduction in dopamine-mediated neurotransmission. This blockade results in decreased psychotic symptoms, particularly in conditions like schizophrenia. By inhibiting dopamine receptors, Thioridazine helps regulate the balance of neurotransmitters in the brain, thereby improving cognitive function and reducing the positive symptoms associated with psychotic disorders. The selective nature of its action on dopamine receptors makes Thioridazine a valuable antipsychotic medication, offering therapeutic benefits without significantly impacting other neurotransmitter systems.

Phenothiazine antipsychotic

Tablet

The following are the uses of Thioridazine 10MG Tablet:

• Used for managing severe mental disorders, primarily schizophrenia.
• Used for reducing hallucinations, delusions, and disordered thinking.
• Used for helping patients with schizophrenia function more effectively in daily life.
• Used for treating symptoms like agitation, aggression, and uncooperative behavior.
• Used for stabilizing mood and improving emotional control in schizophrenic patients.
• Used for enhancing the overall quality of life and social functioning in schizophrenia management.
• Used for long-term maintenance treatment to prevent schizophrenia relapse.

In the case of an overdose of Thioridazine 10MG Tablets, individuals may experience severe side effects. Symptoms can include drowsiness, dizziness, and a significant drop in blood pressure. It is important to recognize that an overdose may lead to an irregular heartbeat, seizures, or even a loss of consciousness. Prompt medical intervention is necessary to manage these potentially life-threatening complications and ensure the well-being of the individual.

In the case of a missed dose of Thioridazine 10MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule and ensure you're taking the medication correctly. It is advisable to set reminders to help you remember to take your medication on time.

To take Thioridazine 10MG Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, ensuring you do not exceed the prescribed amount.

Following are the conditions or circumstances when Thioridazine 10MG Tablet should not be taken:

• Thioridazine 10MG Tablet should not be used in patients with a known allergy to thioridazine or other phenothiazine drugs.
• Contraindicated in patients with a history of severe liver or kidney disease.
• Not suitable for individuals with a history of seizures or epilepsy.
• Should not be used in patients with a blood disorder or bone marrow depression.
• Contraindicated during pregnancy and breastfeeding.
• Avoid in patients with severe central nervous system depression or those in a coma.
• Do not use in patients with known cardiovascular disease or prolonged QT intervals.

The side effects of Thioridazine 10MG Tablet may include:

• Dizziness and lightheadedness
• Dry mouth
• Blurred vision
• Constipation
• Difficulty urinating
• Skin sensitivity to sunlight
• Restlessness or inability to stay still (akathisia)
• Abnormal muscle movements or twitching

Following are the precautions and warnings for Thioridazine 10MG Tablet:

• Do not use this medication if you have a known allergy to Thioridazine or related phenothiazine compounds.
• Thioridazine can cause cardiac arrhythmias, including potentially fatal Torsades de Pointes. ECG monitoring is essential, especially in the elderly and those with cardiac risk factors.
• This medication may cause drowsiness and dizziness. Avoid driving or operating heavy machinery until you know how it affects you.
• Thioridazine can lower the seizure threshold; use with caution in patients with a history of seizures or epilepsy.
• Patients with a history of liver or kidney disease should be monitored closely as Thioridazine is metabolized by the liver and excreted by the kidneys.
• Avoid alcohol consumption while taking Thioridazine as it can increase the risk of side effects.
• Inform your doctor if you have a history of blood disorders, as Thioridazine may affect blood cell counts.
• Thioridazine should be used with caution in the elderly, as they may be more sensitive to its effects and are at higher risk for certain side effects.

Following are the drug interactions for Thioridazine 10MG Tablet:

• Thioridazine can prolong the QTc interval, and co-administration with other drugs that also prolong QTc (e.g., certain antiarrhythmics, antipsychotics, and antibiotics) may increase the risk of serious arrhythmias.
• The use of Thioridazine with central nervous system depressants, such as opioids, benzodiazepines, or alcohol, can lead to enhanced sedation and respiratory depression.
• Antihypertensive medications may have their effects reduced by Thioridazine, potentially leading to uncontrolled blood pressure.
• It may interact with anticoagulants, increasing the risk of bleeding. Close monitoring is required.
• Thioridazine can inhibit certain liver enzymes, leading to increased levels of drugs metabolized by these enzymes, including some antidepressants and antipsychotics.
• Drugs that induce liver enzymes, such as carbamazepine, may decrease Thioridazine levels, potentially reducing its effectiveness.
• The risk of neuroleptic malignant syndrome may be increased when used with other antipsychotic medications.

Following are the food interactions for Thioridazine 10MG Tablet:

• Grapefruit and grapefruit juice should be avoided as they can alter the drug's metabolism, potentially leading to increased side effects.
• Alcohol consumption is not recommended as it may enhance the sedative effects of Thioridazine, causing increased dizziness and drowsiness.
• Foods high in fat can slightly increase the absorption of Thioridazine, but this effect is generally not clinically significant.
• Avoid caffeine or reduce intake as Thioridazine can enhance its effects, possibly leading to increased nervousness and heart rate.
• Salt substitutes containing potassium should be used cautiously as Thioridazine can increase potassium levels in the body.
• Foods rich in vitamin C, like citrus fruits, may reduce the effectiveness of Thioridazine.
• Avoid eating large meals, especially high-fat meals, just before taking Thioridazine as it may affect its absorption.
• Always take the medication as directed by your healthcare professional, regardless of food intake.

Thioridazine 10MG Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, ensuring they are out of reach of children and pets. Maintain a consistent room temperature, avoiding exposure to direct sunlight, moisture, or extreme temperatures, as these conditions can degrade the medication's quality. It is crucial not to dispose of the tablets by flushing them down the toilet or sink; instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for appropriate methods. Proper disposal helps prevent environmental contamination and ensures the safe handling of unused or expired medication. Always keep the tablets in their original container, tightly sealed, to maintain their integrity and effectiveness. Regularly check the expiration date, and discard any medication that has passed its expiry, following recommended disposal practices.

Following are the quick tips for Thioridazine 10MG Tablet:

• Consult a doctor for prescription and dosage instructions specific to your condition.
• Take the tablet as directed, typically 2-4 times daily, with or without food.
• Swallow the tablet whole; do not crush or chew for optimal absorption.
• Maintain a consistent schedule for taking the medication for best results.
• Inform your doctor about all medications you're taking to prevent interactions.
• Do not stop taking the medication abruptly; consult your doctor for tapering instructions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.