Menidazole (200mg) 60ml Suspension

Metronidazole 200mg syrup/suspension primarily exerts its antimicrobial action through the active metabolite, metronidazole. This metabolite is selectively taken up by susceptible anaerobic bacteria and protozoa, where it disrupts DNA synthesis. Specifically, metronidazole interferes with the helical structure of DNA by forming unstable complexes with DNA, leading to strand breakage and inhibition of DNA synthesis. This mechanism selectively targets anaerobic microorganisms, as they rely on anaerobic metabolism for energy production, which is disrupted by the drug's interference with DNA replication and repair processes.

Antiprotozoal/Antibacterial

Suspension

The following are the uses of Metronidazole 200mg Syrup/Suspension:

• Used for treating gastrointestinal infections, such as acute diarrhea and inflammatory bowel disease.
• Used for managing infections caused by anaerobic bacteria, including skin and soft tissue infections.
• Used for controlling certain parasitic infections, particularly those affecting the digestive system.
• Used for reducing inflammation and managing symptoms in conditions like ulcerative colitis and Crohn's disease.
• Used for preventing and treating infections post-surgery, especially in the abdomen or intestines.
• Used for treating dental and oral infections, including periodontal disease and oral abscesses.
• Used for managing complications associated with liver disorders, such as hepatic encephalopathy.

In the case of an overdose of Metronidazole 200mg Syrup/Suspension, several symptoms may occur, including nausea, vomiting, dizziness, and headaches. The severity of the symptoms can vary depending on the amount ingested. It is important to seek medical advice if an overdose is suspected, as prompt treatment can help manage and alleviate these symptoms. In such cases, healthcare professionals should be contacted immediately for guidance and necessary medical intervention.

In the case of a missed dose of Metronidazole 200mg Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for guidance on how to get back on track with your medication regimen.

To administer Metronidazole 200mg Syrup/Suspension, shake the bottle well, measure the prescribed dose with an oral syringe or a measuring cup, and take it orally, as directed by your healthcare provider, typically twice or three times a day, with or without food, ensuring to complete the full course of medication.

Following are the conditions when Metronidazole 200mg Syrup/Suspension should not be used:

• Must not be used in patients with a known allergy or hypersensitivity to Metronidazole or other nitroimidazole derivatives.
• Not suitable for individuals with a history of blood disorders or severe liver disease.
• Contraindicated in patients with a central nervous system disorder, as it can exacerbate these conditions.
• Should not be used in patients with severe kidney disease or on dialysis.
• Avoid in patients with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Not recommended for individuals with a weakened immune system (immunocompromised patients).
• Must not be used to treat viral infections, as it is ineffective against viruses.

The side effects of Metronidazole 200mg Syrup/Suspension may include:

• Nausea and vomiting
• Dry mouth
• Metallic taste in the mouth
• Loss of appetite
• Diarrhea
• Dizziness or lightheadedness
• Headache
• Darkened urine

Following are the precautions and warnings for Metronidazole 200mg Syrup/Suspension:

• Do not consume alcohol while taking this medication and for at least 48 hours after completing treatment, as it may cause severe nausea, vomiting, and other unpleasant side effects.
• Avoid taking this medication if you have a history of blood disorders, as it may affect your blood cells.
• Inform your doctor if you have any liver or kidney disease, as they may need to monitor your condition and adjust the dosage accordingly.
• Metronidazole may cause dizziness or drowsiness, so caution is advised when performing activities that require mental alertness, such as driving or operating machinery.
• It should be used with caution in elderly patients, as they may be more sensitive to the side effects.
• If you have any neurological disorders, consult your doctor before taking this medication, as it may exacerbate these conditions.
• Do not take this medication if you are pregnant or breastfeeding without consulting your healthcare provider, as it may pose risks to the fetus or infant.

Following are the drug interactions for Metronidazole 200mg Syrup/Suspension:

• Avoid concurrent use with disulfiram due to the risk of psychotic reactions.
• Phenytoin levels may be reduced, requiring monitoring and dose adjustment.
• Lithium levels can be increased, potentially leading to lithium toxicity.
• Concomitant use with warfarin may elevate INR, necessitating close monitoring.
• Busulfan levels can be increased, leading to potential toxicity.
• May decrease the effectiveness of oral contraceptives, requiring alternative contraception.
• Alcohol consumption should be avoided to prevent a disulfiram-like reaction.

Following are the food interactions for Metronidazole 200mg Syrup/Suspension:

• Avoid consuming alcohol during and at least 24 hours after the last dose of Metronidazole, as it can cause a severe reaction, including abdominal cramps, nausea, vomiting, headaches, and flushing.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the levels of Metronidazole in the body, potentially leading to increased side effects.
• Dairy products may interfere with the absorption of Metronidazole, so it is advisable to take the medication at least one hour before or two hours after consuming milk, yogurt, or cheese.
• Caffeine-containing beverages like coffee, tea, and energy drinks should be limited as they may increase the stimulatory effects of Metronidazole and cause restlessness or insomnia.
• High-fat meals can potentially slow down the absorption of Metronidazole, leading to a delay in its effectiveness, so it is best to take the medication on an empty stomach or with a light meal.
• Avoid consuming fermented foods like yogurt, sauerkraut, and aged cheeses while on Metronidazole, as they may contain small amounts of alcohol, which can trigger an adverse reaction.
• Sugary foods and beverages should be minimized, as Metronidazole can cause a temporary metallic taste in the mouth, and sugar can exacerbate this side effect.
• Staying well-hydrated by drinking plenty of water is essential when taking Metronidazole, especially if it causes nausea or diarrhea.

Metronidazole 200mg Syrup/Suspension should be stored in a secure location, away from direct sunlight, moisture, and extreme temperatures. Keep it in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is recommended to store it at room temperature, typically between 68°F and 77°F (20°C and 25°C), ensuring it remains stable and effective. Always check the expiration date before use and discard any expired or unused medication responsibly. When disposing of the medication, avoid flushing it down the toilet or pouring it into drains; instead, consult your pharmacist or healthcare professional for appropriate disposal methods. Lastly, ensure the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for Metronidazole 200mg Syrup/Suspension:

• Always follow your doctor's prescription for the duration and dosage of the medication.
• Before each use, shake the bottle vigorously to ensure proper mixing.
• Administer the syrup with water, avoiding tea, coffee, or dairy products for better absorption.
• Maintain a consistent schedule by taking your dose at the same time daily.
• If stomach discomfort occurs, consider taking the syrup with food or after meals.
• Store the medication safely, away from children, to prevent accidental ingestion.
• Do not share your medication with others, even if they have similar symptoms.