MENOGON INJ

Human Menopausal Gonadotropin (HMG) Injection is a combination of two hormones, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity, derived from the urine of menopausal women. The mechanism of action involves the stimulation of ovarian follicles in the ovaries. FSH in the HMG promotes the growth and maturation of multiple ovarian follicles, leading to the development of multiple eggs. Simultaneously, the LH component stimulates the ovaries to produce more hormones, particularly estrogen and progesterone, which are crucial for ovulation and the preparation of the uterine lining for potential pregnancy. By mimicking the natural hormones, HMG triggers a series of physiological processes that support ovulation and enhance the chances of successful fertilization.

Human Menopausal Gonadotrophin

Gonadotropin

injection

The following are the uses of Human Menopausal Gonadotrophin Injection:

• Used for stimulating ovulation in women with fertility issues.
• Used for treating male hypogonadism to boost sperm production.
• Used for addressing infertility caused by hormonal imbalances.
• Used for managing menstrual irregularities and amenorrhea.
• Used for ovarian stimulation in assisted reproductive technologies.
• Used for supporting fertility preservation before certain medical treatments.
• Used for aiding in the diagnosis and management of pituitary disorders.
• Used for helping in the maturation of eggs during in vitro fertilization (IVF) procedures.

In the case of an overdose of Human Menopausal Gonadotrophin Injection, symptoms may include abdominal pain, ovarian enlargement, and multiple pregnancies. Seek medical attention immediately if you suspect an overdose, as prompt treatment can help manage these symptoms effectively. The severity of the overdose may vary, so a healthcare professional should be consulted to determine the appropriate course of action and provide necessary support.

In the case of a missed dose of Human Menopausal Gonadotrophin Injection, it is important to act promptly. If you realize you've missed an injection, administer the missed dose as soon as possible on the same day. However, if the entire day has passed, it is generally recommended to skip the missed dose and continue with the next scheduled injection. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. Consult your healthcare provider if you frequently miss doses to determine the best course of action.

To administer the Human Menopausal Gonadotrophin (HMG) Injection, clean the injection site with an alcohol wipe, insert the needle at a 45-degree angle, inject the prescribed dose slowly, and then gently remove the needle while applying pressure with a sterile cotton ball to prevent any bleeding.

Following are the conditions/situations when Human Menopausal Gonadotrophin (hMG) Injection should not be administered:

• Allergy • Should not be used if the patient has a known allergy or hypersensitivity to hMG, gonadotropins, or any components of the injection.
• Pregnancy • Contraindicated in women who are already pregnant as it can lead to multiple pregnancies and potential complications.
• Ovarian Disorders • Not recommended for women with ovarian failure, primary ovarian insufficiency, or uncontrolled ovarian cysts.
• Endocrine Disorders • Should not be used in individuals with uncontrolled thyroid disorders, adrenal disorders, or pituitary gland tumors.
• Liver Disease • hMG injection is contraindicated in patients with severe liver disease or liver dysfunction.
• Uterine Bleeding • Not suitable for women with undiagnosed abnormal vaginal bleeding or uterine bleeding of unknown cause.
• Ovarian/Pelvic Vein Thrombosis • Should not be used if the patient has a history of thrombosis in the ovarian or pelvic veins.
• Brain Tumors • Contraindicated in patients with untreated or uncontrolled brain tumors.
• Breast Cancer • hMG is not recommended for women with a history of breast cancer or at high risk for breast cancer.
• Endometriosis • Should not be used in women with severe endometriosis.
• Undiagnosed Abnormalities • Not suitable for individuals with undiagnosed vaginal bleeding, breast lumps, or ovarian enlargement.

The side effects of Human Menopausal Gonadotrophin Injection may include:

• Ovarian hyperstimulation syndrome (OHSS)
• Abdominal pain or swelling
• Nausea and vomiting
• Diarrhea
• Headaches
• Fatigue and weakness
• Allergic reactions such as rash, itching, or hives
• Restlessness or irritability

Following are the precautions and warnings for Human Menopausal Gonadotrophin Injection:

• Allergic reactions may occur; patients with known allergies to gonadotropins or other medication components should avoid this medication.
• Not recommended for individuals with uncontrolled thyroid or adrenal dysfunction, or with ovarian cysts/tumors, as it may exacerbate these conditions.
• Patients with a history of cardiovascular disease should be monitored closely, as it may increase the risk of thromboembolic events.
• Ovarian hyperstimulation syndrome (OHSS) is a potential risk; immediate medical attention is required if symptoms such as severe abdominal pain, rapid weight gain, and nausea/vomiting occur.
• Multiple births are more likely with this treatment, which carries additional risks for both mother and babies.
• May cause mild to moderate side effects such as headache, abdominal pain, and mood changes; medical advice should be sought if these symptoms persist or worsen.
• Not recommended for use in children, and the safety and efficacy in pediatric patients have not been established.
• Patients should be informed about the potential risks and benefits, and regular monitoring is essential to ensure a safe and successful treatment outcome.

Following are the drug interactions for Human Menopausal Gonadotrophin Injection:

• Human Menopausal Gonadotrophin may interact with clomiphene citrate, potentially reducing its effectiveness in inducing ovulation.
• When used with letrozole, monitoring is necessary as it may affect ovulation induction outcomes.
• Gonadotropin-releasing hormone (GnRH) agonists or antagonists can interact, requiring careful timing and monitoring to prevent ovarian hyperstimulation syndrome.
• Prolonged use of Human Menopausal Gonadotrophin with GnRH agonists/antagonists may increase the risk of ovarian hyperstimulation.
• Insulin-sensitizing agents like metformin might require dosage adjustments when used together.
• Androgens, such as testosterone, can counteract the effects of Human Menopausal Gonadotrophin, requiring careful monitoring.
• Caution is advised when using with other fertility medications, as it may increase the risk of multiple pregnancies.

Following are the food interactions for Human Menopausal Gonadotrophin Injection:

• Alcohol consumption should be limited as it may interfere with hormone regulation and impact the effectiveness of the injection.
• Avoid excessive caffeine intake as it can disrupt hormone balance and potentially reduce the injection's efficacy.
• Grapefruit and grapefruit juice should be consumed with caution as they may alter hormone metabolism, affecting the treatment outcome.
• Cruciferous vegetables like broccoli, cauliflower, and cabbage contain compounds that can influence estrogen metabolism, so moderate intake is advised.
• Soy products, including tofu and soy milk, contain phytoestrogens, which may interact with the injection's hormone components.
• Limit spicy foods as they can potentially impact the absorption and metabolism of hormones.
• Maintain a balanced diet, ensuring adequate protein, healthy fats, and complex carbohydrates, to support overall health during treatment.
• Consult your healthcare provider for personalized dietary recommendations and to discuss any specific food concerns related to the injection.

Storage and disposal of Human Menopausal Gonadotrophin Injection is crucial for maintaining its efficacy and safety. Store the injection in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F), protected from light and moisture. Do not freeze the injection as it may affect its potency. Always check the expiration date before use and discard any expired or unused medication responsibly. Do not dispose of the injection by flushing it down the toilet or pouring it down the drain; instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for advice on proper disposal methods. Keep the injection out of the sight and reach of children and pets to prevent accidental exposure.

Following are the quick tips for Human Menopausal Gonadotrophin Injection:

• Administer the injection under medical supervision for accurate dosage and technique.
• Ensure the injection is stored at the appropriate temperature, as instructed.
• Follow the prescribed injection schedule for best results.
• Rotate injection sites to minimize discomfort and tissue irritation.
• Dispose of used needles and syringes safely in designated sharps containers.
• Inform your doctor if you experience side effects like abdominal pain or severe headaches.
• Do not reuse or share needles to prevent infections.
• Stay consistent with your treatment plan for optimal outcomes.