Merol (1mg/1ml) 5 Ampoule Injections

Metoprolol, a beta-adrenergic receptor antagonist, primarily acts by competitively blocking beta-1 adrenergic receptors in the heart. This mechanism reduces cardiac output by decreasing heart rate and contractility, resulting in lowered blood pressure. Specifically, metoprolol inhibits the binding of catecholamines, such as adrenaline and noradrenaline, to these receptors, which normally stimulate cardiac functions. By blocking these receptors, metoprolol slows the conduction of electrical impulses in the heart, leading to a decrease in heart rate and a reduction in the force of contraction, ultimately lowering blood pressure and cardiac workload.

Beta-blocker

Injection

The following are the uses of Metoprolol 1mg injection:

• Used for managing angina, effectively reducing chest pain and associated discomfort.
• Used for controlling high blood pressure, helping to lower and stabilize it.
• Used for treating heart rhythm disorders, restoring a regular heartbeat.
• Used for preventing migraines, by managing the frequency and intensity of attacks.
• Used for supporting heart health after a heart attack, aiding recovery.
• Used for managing heart failure, improving heart function and symptoms.
• Used for reducing the risk of future cardiac events in high-risk patients.

In the case of an overdose of Metoprolol 1mg injection, it is important to recognize the signs and act promptly. Symptoms may include severe dizziness, extreme fatigue, and a significant drop in heart rate. Immediate medical intervention is necessary, and the patient should be closely monitored for any adverse effects on the cardiovascular system. Prompt treatment can help mitigate the potentially severe consequences of such an overdose.

In the case of a missed dose of Metoprolol 1mg injection, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for advice on how to safely resume your medication regimen. It is crucial to maintain consistency in taking this medication as prescribed.

To administer Metoprolol 1mg injection, insert the needle into the vial, withdraw 1mg of the medication, and inject it slowly into the muscle, following the prescribed dosage and administration instructions provided by your healthcare professional.

Following are the conditions when Metoprolol 1mg injection should not be administered:

• Should not be used in patients with a known allergy to Metoprolol or other beta-blockers.
• Contraindicated in patients with severe bradycardia (slow heart rate).
• Not suitable for individuals with cardiogenic shock.
• Should not be used in patients with decompensated heart failure.
• Contraindicated in patients with severe hypotension (low blood pressure).
• Should not be administered to patients with severe asthma or chronic obstructive pulmonary disease (COPD).
• Not recommended for individuals with untreated pheochromocytoma.
• Should not be used in patients with sick sinus syndrome.
• Contraindicated during severe forms of peripheral arterial circulatory disorders.
• Not suitable for patients with metabolic acidosis.

The side effects of Metoprolol 1mg injection may include:

• Fatigue and weakness
• Dizziness or lightheadedness
• Slow heart rate (bradycardia)
• Nausea and vomiting
• Shortness of breath
• Cold hands and feet (due to reduced blood flow)
• Impaired sexual function
• Vivid dreams or nightmares

Following are the precautions and warnings for Metoprolol 1mg injection:

• Not recommended for individuals with known hypersensitivity or allergy to Metoprolol or other beta-blockers.
• Metoprolol should be used with caution in patients with respiratory diseases like asthma or chronic obstructive pulmonary disease (COPD) as it may worsen breathing difficulties.
• Patients with heart conditions such as heart block, sick sinus syndrome, or severe heart failure should use this medication under close medical supervision.
• This medication may mask the symptoms of hypoglycemia (low blood sugar), especially in diabetic patients. Regular blood sugar monitoring is advised.
• Caution is advised in patients with peripheral vascular disease, as Metoprolol may exacerbate symptoms of poor circulation.
• Metoprolol can cause dizziness and fatigue; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• It is important to inform your healthcare provider about all medications you are taking, especially those that may interact with Metoprolol, such as other blood pressure medications, diuretics, or anti-diabetic drugs.

Following are the drug interactions for Metoprolol 1mg injection:

• Drugs with negative inotropic effects, such as verapamil or diltiazem, can enhance the effects of Metoprolol, potentially leading to excessive bradycardia and hypotension.
• Combining Metoprolol with other beta-blockers may result in additive effects and increase the risk of bradycardia and hypotension.
• The use of Metoprolol with class I antiarrhythmic agents (e.g., quinidine) may cause additive effects on heart rate and atrioventricular conduction.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the antihypertensive effects of Metoprolol.
• Metoprolol can increase the concentration of lithium, potentially leading to lithium toxicity.
• It may decrease the elimination of clonidine, resulting in increased levels and possible side effects.
• Rifampin can reduce the effectiveness of Metoprolol by inducing its metabolism.
• The use of Metoprolol with insulin or oral hypoglycemic agents may mask some of the manifestations of hypoglycemia, especially tachycardia.

Following are the food interactions for Metoprolol 1mg injection:

• Avoid consuming large amounts of grapefruit or grapefruit juice as it may increase the levels of Metoprolol in the blood, potentially causing adverse effects.
• Alcohol consumption should be limited or avoided as it can lower blood pressure further, leading to excessive dizziness and drowsiness.
• Caffeinated beverages like coffee or energy drinks may counteract the effects of Metoprolol, reducing its effectiveness in controlling blood pressure.
• Foods rich in Vitamin K, such as leafy greens, broccoli, and soybeans, should be consumed in moderation as Metoprolol may interfere with blood clotting.
• Salt and salty foods should be reduced in the diet to support the medication's blood pressure-lowering effect.
• A balanced diet with whole grains, fruits, and vegetables is generally recommended to support overall cardiovascular health.
• Always consult your healthcare provider for specific dietary recommendations while using Metoprolol.

Metoprolol 1mg injection should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 68°F and 77°F (20°C and 25°C). Protect the injection from direct sunlight, as exposure to light can degrade its potency. Store it in a safe and secure location, away from children and pets, to prevent accidental ingestion or misuse. Do not freeze the injection as it may affect its stability. Once opened, the injection should be used promptly, and any unused portion should be discarded. Dispose of the injection responsibly by following local guidelines for pharmaceutical waste disposal, ensuring it is not flushed down the toilet or poured into drains to minimize environmental impact.

Following are the quick tips for Metoprolol 1mg injection:

• Consult your doctor for proper dosage and administration instructions.
• Ensure the injection is administered by a trained healthcare professional.
• Verify the medication's identity and expiration date before use.
• Inform your doctor about any allergies or medical conditions.
• Avoid rapid injection; administer slowly as directed.
• Store the injection as directed; protect it from light and extreme temperatures.
• Do not reuse needles or syringes; dispose of them safely.
• Report any side effects or unusual symptoms to your healthcare provider promptly.