Merosol (1g) Vial Injection

Meropenem 1000mg injection, a potent broad-spectrum antibiotic, exerts its bactericidal effect by interfering with bacterial cell wall synthesis. It selectively binds to and inhibits specific penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan strands in the bacterial cell wall. This binding leads to the weakening and eventual rupture of the cell wall, resulting in the death of the bacteria. Meropenem is particularly effective against a wide range of Gram-positive and Gram-negative bacteria, including those producing extended-spectrum beta-lactamases, by maintaining its stability against these enzymes and ensuring its ability to bind to PBPs.

Carbapenem antibiotic.

injection

The following are the uses of Meropenem 1000mg injection:

• Used for treating severe bacterial infections, particularly those caused by resistant organisms.
• Used for infections in the abdomen, skin, and blood.
• Used in cases of hospital-acquired pneumonia and ventilator-associated pneumonia.
• Effective against a broad range of gram-negative and gram-positive bacteria.
• Used as a last-resort treatment for severe, life-threatening infections.
• Administered to patients with impaired kidney function or those undergoing dialysis.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Ulcerative Colitis- 1000 mg every 6 hours for mild to moderate infection; 1000 mg every 8 hours IV (intravenous) or IM (intramuscularly) for severe infection
• Carbapenem-Resistant Escherichia coli Infection- 1g every 8 hours IV
• Skin and Skin Structure Infection- 500 mg to 1000 mg every 12 hours IV transition to oral medication
• Bloodstream Infection (BSI)- 1 g every 8 hours IV
• Liver Abscess- 1 g every 8 hours IV
• Pelvic Inflammatory Disease- 1 g every 8 hours IV
• Bone and Joint Infection- 1 g every 8 hours IV
• Respiratory Tract Infection- 500 mg to 1000 mg every 8 hours IV
• Urinary Tract Infection- 500 mg to 1000 mg every 8 hours IV
• Meningitis- 1 g every 8 hours IV

In the case of an overdose of Meropenem 1000mg injection, the primary concern is the potential for severe gastrointestinal symptoms. These may include intense nausea, persistent vomiting, and abdominal discomfort. Additionally, an overdose could lead to neurological issues, such as dizziness, confusion, or in extreme cases, seizures. It is crucial to monitor for these symptoms and seek medical advice promptly if an overdose is suspected, as early intervention can help mitigate these adverse effects.

In the case of a missed dose of Meropenem 1000mg injection, it is important to administer the missed dose as soon as possible. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you have missed multiple doses, contact your healthcare provider for guidance on how to resume your medication safely. It is crucial to maintain a consistent medication routine for optimal treatment outcomes.

To administer Meropenem 1000mg injection, reconstitute the powder with the provided sterile water, gently swirl to dissolve, and then inject the entire contents intramuscularly or intravenously as directed by your healthcare professional.

Here are the conditions or situations when Meropenem 1000mg injection should not be administered:

• Should not be used in patients with a confirmed hypersensitivity or severe allergic reaction to Meropenem or other carbapenem antibiotics.
• Contraindicated in patients with a history of severe or life-threatening allergic reactions to any beta-lactam antibiotics (such as penicillins or cephalosporins).
• Not recommended for individuals with severe kidney disease or those on dialysis, without adjusting the dose appropriately.
• Should be avoided in patients with a history of seizures or conditions that increase the risk of seizures, as Meropenem may lower the seizure threshold.
• Not suitable for patients with a known or suspected infection caused by MRSA (methicillin-resistant Staphylococcus aureus) or other organisms resistant to Meropenem.
• Should not be used to treat viral infections or non-bacterial infections, as it is ineffective against these conditions.
• Contraindicated in patients with a history of Clostridioides difficile-associated diarrhea or colitis, as it may worsen these conditions.

The side effects of Meropenem 1000mg injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rashes or itching
• Headache
• Dizziness
• Injection site reactions (pain, swelling, or redness)
• Seizures (rarely)
• Allergic reactions (e.g., hives, difficulty breathing, swelling of the face or throat)

Following are the precautions and warnings for Meropenem 1000mg Injection:

• Not suitable for patients with a known hypersensitivity to meropenem or other carbapenem antibiotics, as it may cause severe allergic reactions, including anaphylaxis.
• Caution is required in patients with a history of penicillin or cephalosporin allergy due to potential cross-reactivity.
• Use with caution in patients with renal impairment, as dose adjustments may be necessary to prevent drug accumulation and toxicity.
• Prolonged use may lead to superinfection, including Clostridium difficile-associated diarrhea.
• Central nervous system side effects, including seizures, may occur, especially in patients with a history of neurological disorders or renal dysfunction.
• Intravenous administration should be closely monitored to avoid infusion-related reactions, such as thrombophlebitis.
• Regular kidney and liver function tests should be performed during prolonged therapy to monitor for toxicity.
• Use with caution in elderly patients, as they may be more susceptible to side effects, including renal impairment.
• Avoid mixing meropenem with other intravenous medications unless compatibility is confirmed.
• Complete the full course of treatment as prescribed to prevent bacterial resistance.

Following are the drug interactions for Meropenem 1000mg injection:

• Probenecid can decrease renal tubular secretion of meropenem, potentially increasing its serum levels.
• Concomitant use with valproic acid may increase the risk of seizures.
• Meropenem may reduce the effectiveness of oral contraceptives, requiring alternative contraceptive methods.
• May interact with anticoagulants, increasing the risk of bleeding. Close monitoring is advised.
• When combined with certain immunosuppressants, such as mycophenolate mofetil, meropenem may decrease the immunosuppressant's concentration.
• The effectiveness of vaccines might be reduced by meropenem, especially live attenuated vaccines.
• Concurrent use with other antibiotics, such as vancomycin, may increase the risk of antibiotic-associated colitis.

Following are the food interactions with Meropenem 1000mg injection:

• Meropenem should be administered on an empty stomach, at least one hour before or two hours after meals, as food can decrease its absorption.
• Avoid consuming alcohol during the treatment period, as it may increase the risk of side effects and reduce the effectiveness of the medication.
• Grapefruit and grapefruit juice are to be avoided as they may interfere with the metabolism of Meropenem, leading to increased drug levels in the body.
• Caffeine-rich beverages like coffee and tea should be limited as they can potentially decrease Meropenem's effectiveness.
• Dairy products, especially milk, might reduce the absorption of Meropenem, so ensure a sufficient gap between medication and dairy intake.
• High-fat meals can delay the absorption of Meropenem, so it's best to maintain a low-fat diet during the treatment.
• Avoid herbal supplements, particularly those containing St. John's Wort, as they can affect the efficacy of Meropenem.
• Always consult your healthcare provider for specific dietary recommendations while using this medication.

Meropenem 1000mg injection should be stored in a controlled environment, preferably between 68°F and 77°F (20°C and 25°C), allowing for some flexibility in room temperature storage. Protect the injection from light by storing it in its original packaging, ensuring the container is tightly sealed to maintain its integrity and sterility. Avoid exposure to extreme temperatures, and never freeze the medication. It is crucial to dispose of any unused or expired Meropenem injection responsibly, avoiding improper disposal methods like flushing or pouring down the drain. Instead, consult a pharmacist or healthcare professional for guidance on safe disposal practices, ensuring that the medication does not contaminate the environment. Keep the injection out of children's reach to prevent accidental exposure.

Following are the quick tips for Meropenem 1000mg Injection:

• Administer the injection under medical supervision as prescribed.
• Ensure the injection is prepared and administered by trained medical professionals.
• The injection should be given slowly over a recommended time frame.
• Follow the prescribed dosage and duration as instructed by your doctor.
• Do not stop the medication without consulting your healthcare provider.
• Inform your doctor if you have any allergies or kidney/liver issues before starting the medication.
• Store the injection as directed, away from direct sunlight and moisture.

Meropenem is a powerful antibiotic used to treat various bacterial infections, and its use may be accompanied by several routine laboratory tests to monitor safety and effectiveness. These tests are used to ensure that the medication is excreted properly and that organ functions, such as kidney and liver functions, remain intact. Blood chemistry panels, CBC tests, and kidney function tests, including serum creatinine, BUN, and GFR measurements, are commonly ordered. These tests assess essential chemical components in the blood, monitor potential kidney damage, and measure red and white blood cell counts, along with platelet levels. Liver function tests, including ALT, AST, bilirubin, and albumin, are often included to monitor liver health. Additionally, calcium levels are typically monitored, especially at higher Meropenem doses, as it can occasionally cause low calcium levels. The importance of these tests is to ensure that the medication is effective and safe for the patient, and that organ functions are not compromised. The tests also help to mitigate and alert physicians to any adverse effects and can guide dosage adjustments.