Metcon (150/5mg) 30 Tablets

Paracetamol, also known as acetaminophen, primarily exerts its analgesic and antipyretic effects by inhibiting the synthesis of prostaglandins in the central nervous system. It acts on specific areas of the brain that regulate pain perception and body temperature. On the other hand, Metoclopramide, a dopamine D2 receptor antagonist, increases gastric motility by blocking dopamine receptors in the chemoreceptor trigger zone, which reduces nausea and vomiting. This mechanism helps improve gastric emptying and promotes upper gastrointestinal tract motility. Together, these actions contribute to the combined effect of the Paracetamol and Metoclopramide tablet in managing pain, fever, and gastrointestinal symptoms.

Analgesic, Antiemetic.

Tablet

The following are the uses of Paracetamol, Metoclopramide Tablet:

• Used for relieving pain and reducing fever
• Used to treat headaches, toothaches, and minor aches and pains
• Effective for managing discomfort associated with colds and flu
• Helps alleviate menstrual cramps and muscle soreness
• Provides relief for mild to moderate pain, offering a safe and reliable option
• Useful in combination with other medications for comprehensive pain management
• Aids in reducing nausea and vomiting, enhancing overall comfort

In the case of an overdose of Paracetamol and Metoclopramide Tablets, individuals may experience a range of symptoms. These can include gastrointestinal issues such as nausea, vomiting, and abdominal pain. Additionally, there is a risk of liver damage with Paracetamol overdose, which can lead to jaundice, fatigue, and impaired liver function. It is important to seek medical advice promptly if an overdose is suspected to prevent potential complications.

In the case of a missed dose of Paracetamol, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. For Metoclopramide Tablet, if you miss a dose, take it as soon as you remember, but if it's close to the time for your next dose, skip the missed dose and continue with your regular dosing frequency. Do not double the dose to make up for a missed one.

To take the Paracetamol and Metoclopramide tablet, swallow the tablet whole with a full glass of water, preferably before a meal, following the dosage instructions provided by your healthcare professional, typically taken once or twice a day as directed.

Here are the conditions or situations when Paracetamol and Metoclopramide Tablet should not be used:

• Avoid using this medication if you have a known allergy or hypersensitivity to Paracetamol or Metoclopramide, or any other similar medications.
• Do not take this tablet if you have a history of bleeding in the stomach or intestines, or if you have a blockage in your digestive system.
• Contraindicated in individuals with a suspected or existing blood disorder called pheochromocytoma.
• Should not be used in patients with a history of seizures or epilepsy.
• Not suitable for individuals with liver or kidney disease or impairment.
• Do not use this medication if you have recently undergone brain surgery.
• Avoid using this tablet if you have a tumor on your adrenal gland (neuroleptic malignant syndrome).
• Contraindicated during pregnancy or breastfeeding without medical advice.
• Not recommended for children below a certain age (consult a doctor for specific age restrictions).

The side effects of Paracetamol, Metoclopramide Tablet may include:

• Nausea and vomiting
• Drowsiness or fatigue
• Restlessness or agitation
• Diarrhea
• Skin rashes or itching
• Dizziness
• Muscle stiffness or spasms
• Restlessness

Following are the precautions and warnings for Paracetamol, Metoclopramide Tablet:

• Do not exceed the recommended dosage, as Paracetamol overdose can cause severe liver damage.
• This medication should be used with caution in patients with liver or kidney impairment, and regular monitoring of liver function is advised.
• Patients with gastrointestinal conditions such as gastrointestinal bleeding, obstruction, or perforation should not take Metoclopramide.
• Avoid using this medication if you have a history of seizures or epilepsy, as it may lower the seizure threshold.
• Paracetamol may interact with other medications, so inform your doctor about all the medicines you are currently taking.
• Metoclopramide may cause extrapyramidal reactions, especially in children and young adults; monitor for symptoms such as involuntary movements.
• Do not use this medication for prolonged periods without medical supervision, as it may lead to tardive dyskinesia.
• Patients with diabetes should use caution as Metoclopramide can affect blood glucose levels.

Following are the drug interactions for Paracetamol and Metoclopramide Tablet:

• Paracetamol may increase the risk of liver damage when taken with other potentially hepatotoxic medications like certain antibiotics (e.g., isoniazid) or alcohol.
• It can interact with anticoagulants (e.g., warfarin), potentially altering their effects and requiring closer monitoring of blood clotting parameters.
• Metoclopramide can enhance the effects of certain medications like opioids, leading to increased sedation and respiratory depression.
• Caution is advised when combining Metoclopramide with other drugs that affect the central nervous system, such as benzodiazepines or antidepressants, due to potential additive CNS effects.
• The effects of Metoclopramide may be reduced by medications that increase gastric pH, such as proton pump inhibitors (PPIs).
• Metoclopramide can inhibit the action of dopamine agonists and antagonists, affecting the treatment of Parkinson's disease.
• It may also interact with certain antipsychotic medications, increasing the risk of extrapyramidal symptoms.

Following are the food interactions for Paracetamol and Metoclopramide Tablet:

• Alcohol intake should be avoided or limited as it may increase the risk of liver damage when combined with Paracetamol.
• Grapefruit and grapefruit juice should be avoided as they can inhibit the metabolism of Metoclopramide, leading to increased drug levels and potential side effects.
• Fatty foods may delay the absorption of Paracetamol, but this effect is usually not clinically significant.
• Avoid caffeine-rich beverages as Metoclopramide may increase caffeine levels in the body, leading to restlessness and insomnia.
• Avoid eating large meals after taking Metoclopramide as it can speed up gastric emptying, and eating a large meal may reduce its effectiveness.
• No significant food interactions are known for Paracetamol, but always follow your doctor's advice on medication intake.
• Spicy foods may be avoided as Metoclopramide can increase gastric acid production, potentially causing discomfort.
• Maintain a balanced diet and stay hydrated to support overall health while taking these medications.

Paracetamol and Metoclopramide tablets should be stored in a cool, dry place, preferably in their original container, away from direct sunlight and moisture. It is crucial to keep the medication away from heat sources like ovens or radiators as temperature fluctuations can impact its effectiveness. Always check the expiry date, and dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult a pharmacist or healthcare professional for guidance on proper disposal methods. Ensure the medication is stored out of children's reach to prevent accidental consumption. When discarding, follow local regulations for pharmaceutical waste disposal to minimize environmental impact.

Following are the quick tips for Paracetamol, Metoclopramide Tablet:

• Consult a doctor for proper dosage and duration based on your condition.
• Swallow the tablet whole with water; do not crush or chew.
• Take the tablet with food to minimize stomach irritation.
• Do not drive or operate machinery if you feel drowsy after taking the medication.
• Avoid alcohol consumption as it may increase the risk of side effects.
• Inform your doctor about all medications you are taking to prevent interactions.
• Store the tablets in a cool, dry place away from direct sunlight.
• Do not share your medication with others, even if their symptoms are similar.