Metenix (5mg) 100 Tablets

Metolazone is a thiazide-like diuretic that primarily acts on the distal convoluted tubule (DCT) and early part of the cortical collecting duct in the kidneys. Its mechanism of action involves inhibiting the reabsorption of sodium and chloride ions, leading to increased excretion of sodium, chloride, and water. Metolazone binds to and blocks the thiazide-sensitive sodium-chloride cotransporter (NCC) in the DCT, which is responsible for the reabsorption of approximately 5% of the filtered sodium load. By inhibiting this transporter, metolazone promotes the loss of sodium, chloride, and water, resulting in increased diuresis and a reduction in extracellular fluid volume. This mechanism makes metolazone effective in lowering blood pressure and managing fluid retention, particularly in conditions where other diuretics may be less effective.

Thiazide Diuretic

Tablet

The following are the uses of Metolazone 5mg Tablet:

• Used for treating fluid retention (edema) associated with heart, liver, or kidney disease.
• Used for managing high blood pressure, helping to lower and control blood pressure.
• Used for promoting diuresis, increasing urine output to eliminate excess fluid.
• Used for reducing swelling in conditions like lymphedema or post-surgical edema.
• Used for improving kidney function in certain chronic kidney diseases.
• Used for preventing fluid build-up in respiratory conditions like pulmonary edema.
• Used for supporting weight loss in cases of fluid retention-induced weight gain.
• Used for enhancing the effectiveness of other diuretic medications when used together.

In the case of an overdose of Metolazone 5mg Tablets, it is important to act swiftly. Symptoms may include severe dizziness, extreme thirst, and an increased need to urinate. Seek medical assistance immediately, as prompt treatment can prevent serious complications. Do not induce vomiting without professional advice, as this could worsen the situation. Quick action and professional guidance are essential to ensure the best possible outcome.

In the case of a missed dose of Metolazone 5mg Tablet, it is important to take the dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss several doses, consult your healthcare provider for advice on how to safely resume your medication and adjust your dosing schedule. It is recommended to set a daily reminder to help you remember to take your medication as prescribed.

To take Metolazone 5mg Tablet, swallow the tablet whole with a full glass of water, preferably in the morning as directed by your healthcare provider, and follow any specific instructions for dosage and timing provided by them.

Following are the conditions/situations when Metolazone 5mg Tablet should not be used:

• Should not be taken by individuals with a known allergy to Metolazone or any sulfonamide-derived medications.
• Contraindicated in patients with severe kidney disease or those who are unable to produce urine.
• Not suitable for individuals with severe liver disease or liver failure.
• Should not be used if you have a condition called Addison's disease (a disorder of the adrenal glands).
• Contraindicated during pregnancy, especially during the first and second trimesters.
• Not recommended for breastfeeding mothers, as it may pass into breast milk and harm the nursing infant.
• Should not be given to children below 18 years of age, except under specific medical circumstances.
• Avoid if you have a history of electrolyte imbalances, especially low potassium levels (hypokalemia).
• Do not take if you have a history of gout, as it may increase the risk of gout attacks.
• Metolazone should not be used if you have diabetes, as it may affect blood sugar levels.

The side effects of Metolazone 5mg Tablet may include:

• Increased urination
• Low blood pressure (hypotension)
• Electrolyte imbalances, such as low potassium (hypokalemia) or low sodium (hyponatremia)
• Muscle cramps
• Weakness or fatigue
• Dizziness or lightheadedness
• Headache
• Gastrointestinal disturbances (e.g., nausea, diarrhea)

Following are the precautions and warnings for Metolazone 5mg Tablet:

• Not recommended for patients with severe kidney disease, as it can lead to further deterioration of kidney function.
• Regular monitoring of kidney function and electrolyte levels is necessary during treatment, especially in elderly patients.
• May cause an increase in uric acid levels, so caution is advised in patients with a history of gout.
• Can lead to an increased risk of low blood pressure, particularly when used with other blood pressure medications.
• Patients with diabetes should be cautious as Metolazone may alter blood sugar levels.
• May cause an allergic reaction; discontinue use if you experience any signs of anaphylaxis.
• Not recommended for long-term use without regular medical supervision due to potential electrolyte imbalances.

Following are the drug interactions for Metolazone 5mg Tablet:

• Concurrent use with other diuretics (e.g., furosemide, hydrochlorothiazide) may lead to an increased risk of electrolyte imbalances (e.g., hypokalemia, hyponatremia) and dehydration.
• Combination with ACE inhibitors (e.g., enalapril, lisinopril) may increase the risk of hyperkalemia, particularly in patients with renal impairment.
• Use with lithium may increase the risk of lithium toxicity due to decreased renal clearance.
• Nonsteroidal anti-inflammatory drugs (NSAIDs, e.g., ibuprofen, naproxen) may reduce the diuretic effect of Metolazone and increase the risk of renal dysfunction.
• Combination with corticosteroids (e.g., prednisone) may increase the risk of electrolyte imbalances, such as hypokalemia and sodium retention.
• Use with digitalis (e.g., digoxin) may increase the risk of digitalis toxicity, particularly in patients with low potassium levels.
• Concomitant use with other antihypertensive medications (e.g., beta-blockers, calcium channel blockers) may lead to an additive effect, causing excessive blood pressure lowering.
• Metolazone may reduce the efficacy of antidiabetic medications, requiring closer monitoring of blood sugar levels.
• Use with alcohol may enhance the hypotensive effect of Metolazone, increasing the risk of dizziness and fainting.

Following are the food interactions to be aware of when taking Metolazone 5mg Tablets:

• Avoid excessive salt intake, as Metolazone is a diuretic and can lead to increased salt loss, potentially causing electrolyte imbalances.
• Limit potassium-rich foods like bananas, oranges, and spinach, as Metolazone may cause potassium loss, and excessive intake might be harmful.
• Reduce your alcohol consumption, as it can increase the risk of dizziness and lightheadedness, especially when combined with the diuretic effects of Metolazone.
• Be cautious with grapefruit and grapefruit juice, as they may affect the metabolism of Metolazone, potentially altering its effectiveness.
• Maintain a balanced diet, as Metolazone may impact your body's fluid and electrolyte balance, and proper nutrition is essential for overall health.
• Avoid high-sodium processed foods, as they can counteract the diuretic effect of Metolazone and lead to fluid retention.
• Stay hydrated, but avoid excessive fluid intake, as Metolazone may cause increased urination, and maintaining a balanced fluid intake is important.
• Consult your healthcare provider for personalized dietary advice, especially if you have specific dietary restrictions or medical conditions.

Metolazone 5mg Tablets should be stored in a cool, dry location away from direct sunlight and moisture. It is crucial to store the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing the tablets to heat or freezing temperatures, as this can impact their effectiveness. Dispose of any unused or expired medication responsibly; do not flush or pour them down the drain. Contact your pharmacist or local waste management authority for guidance on proper disposal methods. Keep the medication out of children's reach to prevent accidental ingestion, ensuring the safety of your household. Regularly review the medication's expiration date, and consult a healthcare professional if you have any concerns or questions about storage and disposal.

Following are the quick tips for Metolazone 5mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Consume the tablet with a full glass of water, preferably in the morning.
• Maintain a consistent daily routine for taking the medication.
• Avoid taking this tablet with other diuretics without medical advice.
• Inform your doctor about all medications you are taking to prevent potential interactions.
• Do not stop taking the medication abruptly without consulting your healthcare provider.
• Store the tablets at room temperature, away from moisture and light.
• Regularly monitor your blood pressure and kidney function while on this medication.