Metgyl (400mg) 100 Tablets

Metronidazole 400mg tablets primarily exert their therapeutic effect through the active metabolite, metronidazole. This metabolite disrupts the DNA structure and inhibits nucleic acid synthesis in susceptible organisms, leading to cell death. The mechanism involves the reduction of metronidazole within the organism, producing toxic intermediates that bind to DNA, causing strand breaks and inhibiting DNA synthesis. This process specifically targets anaerobic bacteria and protozoa, as these organisms thrive in low-oxygen environments where the reduction of metronidazole is facilitated. The selective toxicity of metronidazole is attributed to its reduced activity in aerobic environments, making it particularly effective against anaerobic pathogens.

Antibiotic, Antiprotozoal.

Tablet

The following are the uses of Metronidazole 400mg Tablet:

• Used for treating bacterial infections, particularly those caused by anaerobic bacteria.
• Used for controlling intestinal infections and inflammation.
• Used for managing infections in the female reproductive system.
• Used for treating skin and soft tissue infections.
• Used for certain types of parasitic infections, including those affecting the digestive system.
• Used for preventing and treating infections post-surgery or in immunocompromised patients.
• Used for managing dental infections and oral abscesses.
• Used for treating certain sexually transmitted infections (STIs) caused by susceptible organisms.

In the case of an overdose of Metronidazole 400mg Tablets, it is important to seek medical advice promptly. Symptoms of an overdose may include nausea, vomiting, dizziness, and headaches. The severity of these symptoms can vary, and they may lead to more serious complications. Treatment for an overdose should be administered by a healthcare professional, who can provide the necessary care and support to manage any adverse effects and ensure a full recovery. Prompt action is essential in such situations.

In the case of a missed dose of Metronidazole 400mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is generally advised not to double the dose to make up for a missed one. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Always consult your healthcare provider if you have any concerns or questions about missed doses.

To take Metronidazole 400mg Tablet, swallow the tablet whole with a full glass of water, preferably with or after a meal, following the prescribed dosage instructions provided by your healthcare professional.

Here are the conditions and situations when Metronidazole 400mg Tablet should not be taken:

• Avoid in patients with a known allergy or hypersensitivity to Metronidazole or other nitroimidazole derivatives.
• Not recommended for individuals with a history of severe liver disease or current acute hepatitis.
• Contraindicated in patients with a blood disorder called leukopenia (low white blood cell count).
• Should not be used if you have a central nervous system disease or previous history of seizures, as it can lower the seizure threshold.
• Avoid alcohol consumption during treatment and for at least 72 hours after discontinuation of Metronidazole, as it can cause severe adverse reactions.
• Not suitable for individuals with a history of blood disorders such as anemia or reduced red blood cell count.
• Should not be used in patients with severe kidney disease or those on dialysis.

The side effects of Metronidazole 400mg Tablet may include:

• Nausea and vomiting
• Dry mouth or metallic taste
• Loss of appetite
• Headache
• Dizziness
• Darkening of urine
• Skin rashes or itching
• Neurological side effects like numbness or tingling in the hands or feet

Following are the precautions and warnings for Metronidazole 400mg Tablet:

• Avoid alcohol consumption while taking this medication and for at least 48 hours after completing the treatment, as it can cause severe nausea, vomiting, and other unpleasant reactions.
• This medication should be used with caution in patients with liver or kidney disease, as it is primarily metabolized by the liver and excreted by the kidneys.
• Metronidazole may cause dizziness or lightheadedness; patients should be cautious when driving or operating machinery until they know how the medication affects them.
• It is important to complete the full course of treatment as prescribed, even if symptoms improve before completion, to ensure the infection is fully eradicated.
• Inform your healthcare provider if you have a history of blood disorders or epilepsy, as Metronidazole may worsen these conditions.
• Not recommended for use during pregnancy, especially during the first trimester, due to potential risks to the fetus. Effective contraception is advised while taking this medication.
• Patients with central nervous system diseases or a history of seizures should use this medication with caution, as it may lower the seizure threshold.
• Discontinue the medication and seek medical attention if you experience severe or persistent side effects, such as tingling in the hands or feet, difficulty breathing, or severe abdominal pain.

Following are the drug interactions for Metronidazole 400mg Tablet:

• Alcohol consumption should be avoided as it can cause a disulfiram-like reaction with symptoms like nausea, vomiting, flushing, and headaches.
• Concomitant use with warfarin may increase the risk of bleeding, so regular monitoring of prothrombin time is necessary.
• It can interact with Lithium, leading to increased lithium levels and potential toxicity.
• Phenytoin levels may be elevated, increasing the risk of phenytoin toxicity.
• The effectiveness of oral contraceptives can be reduced, requiring alternative contraception methods during and shortly after treatment.
• Busulfan metabolism can be altered, potentially increasing busulfan levels and toxicity.
• May decrease the effectiveness of immunosuppressants like ciclosporin and tacrolimus.

Following are the food interactions for Metronidazole 400mg Tablet:

• Avoid alcohol consumption during and at least 24 hours after metronidazole treatment. It can cause a disulfiram-like reaction with symptoms like nausea, vomiting, flushing, headache, and rapid heart rate.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of Metronidazole, potentially leading to increased drug levels and an elevated risk of side effects.
• Dairy products like milk, yogurt, and cheese may reduce the absorption of Metronidazole. Consider taking the medication at least one hour before or two hours after consuming dairy.
• Caffeine intake should be limited as it can potentially enhance the side effects of Metronidazole, particularly nervous system stimulation.
• Avoid fermented foods like aged cheeses, cured meats, and certain types of bread, as they may contain microorganisms that could potentially interact with Metronidazole.
• Fatty or greasy foods may delay the absorption of Metronidazole, so it's best to take the medication on an empty stomach or with a light meal.
• Vitamin and mineral supplements, especially iron and calcium supplements, may interfere with Metronidazole absorption. Take them at different times to ensure optimal absorption of both substances.
• Certain herbal supplements, such as St. John's Wort, may affect Metronidazole metabolism. Consult a healthcare professional before combining herbal remedies with this medication.

Metronidazole 400mg Tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain the integrity of the medication. It is crucial not to store the tablets in the bathroom or near heat-emitting appliances, as temperature fluctuations can compromise their effectiveness. Proper disposal of unused or expired tablets is essential; avoid flushing them down the toilet or pouring them into drainage systems. Consult your pharmacist or healthcare provider for appropriate disposal guidelines to prevent environmental contamination. Always keep medications securely stored and out of the reach of children to prevent accidental ingestion.

Following are the quick tips for Metronidazole 400mg Tablet:

• Consult your doctor before starting this medication for proper dosage and duration.
• Complete the full course of medication as prescribed, even if you feel better earlier.
• Take the tablet with a full glass of water, preferably at the same time each day.
• Avoid alcohol consumption while taking this medication and for at least 48 hours after completion.
• Do not crush or chew the tablet; swallow it whole for optimal effectiveness.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.