METHERGIN TAB

Methylergometrine, also known as methylergonovine, primarily acts as an agonist of serotonin receptors, particularly the 5-HT2A receptor subtype. This mechanism of action is responsible for its uterotonic effects. By stimulating the serotonin receptors in the smooth muscle of the uterus, methylergometrine enhances uterine contractions, leading to increased tone and improved contraction efficiency. This action helps in the prevention and control of postpartum hemorrhage by promoting the contraction of the uterine muscles and facilitating the constriction of blood vessels in the uterine wall, thereby reducing blood loss after childbirth.

Ergot alkaloid derivative

Tablet

The following are the uses of Methylergometrine Tablet:

• Used for preventing and controlling bleeding after childbirth
• Used for inducing uterine contractions during the third stage of labor
• Used for treating severe postpartum hemorrhage
• Used for managing incomplete or missed abortions
• Used for controlling bleeding in gynecological surgeries
• Used for managing uterine bleeding disorders
• Used for treating migraine headaches associated with menstruation

In the case of an overdose of Methylergometrine Tablets, several symptoms may manifest. These can include severe nausea, persistent vomiting, intense headaches, and heightened blood pressure. Additionally, individuals may experience chest pain, a rapid or irregular heartbeat, and a feeling of restlessness or anxiety. Prompt medical intervention is necessary to manage these symptoms effectively and prevent potential complications.

In the case of a missed dose of Methylergometrine Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you have missed multiple doses or are unsure about how to proceed, contact your healthcare provider for guidance. They can provide specific instructions based on your medical condition and treatment plan.

To take Methylergometrine Tablets, place the tablet under the tongue (sublingually) and allow it to dissolve completely, preferably without swallowing for optimal absorption; take it as directed by your healthcare professional, typically 3-4 times a day after meals and at bedtime, following the prescribed dosage and duration provided by your doctor.

Here are the conditions and situations when Methylergometrine Tablet should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to methylergometrine or other ergot alkaloids.
• Contraindicated in patients with severe hypertension (high blood pressure) as it may further increase blood pressure.
• Not recommended for individuals with severe cardiovascular disease, including coronary artery disease or peripheral vascular disease.
• Should be avoided in patients with impaired liver function or liver disease, as it is metabolized by the liver.
• Contraindicated during pregnancy, especially in the first trimester, due to potential risks to the fetus.
• Should not be used in patients with severe renal (kidney) impairment as it may lead to accumulation of the drug.
• Not suitable for individuals with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Should be used with caution and avoided if possible in patients with severe migraine headaches or a history of migraine with aura.
• Contraindicated in patients with peripheral vascular disease, as it may worsen blood circulation issues.
• Not recommended for individuals with severe gastrointestinal disorders, such as inflammatory bowel disease or intestinal ischemia.

The side effects of Methylergometrine Tablet may include:

• Nausea and vomiting
• Abdominal pain or cramps
• Headache
• Dizziness or lightheadedness
• Slow or irregular heartbeat
• High blood pressure (hypertension)
• Shortness of breath
• Allergic reactions, such as rash, itching, or difficulty breathing.

Following are the precautions and warnings for Methylergometrine Tablet:

• Not recommended for individuals with a known allergy to methylergometrine or related ergot alkaloids.
• Should be used with caution in patients with hypertension, cardiovascular disease, or impaired liver function as it may worsen these conditions.
• Methylergometrine can cause vasoconstriction, so patients with peripheral vascular disease should be closely monitored.
• Not recommended for prolonged use; prolonged or excessive use may lead to ergotism, a serious condition with various symptoms.
• Patients should be advised to seek medical attention if they experience persistent or severe headache, nausea, vomiting, or signs of peripheral ischemia.
• It may interact with other medications, especially those affecting blood pressure or vascular tone, so a healthcare professional should be consulted before starting any new medication.
• Not recommended for use during pregnancy, especially in the first trimester, due to potential risks to the fetus.

Following are the drug interactions for Methylergometrine Tablet:

• Prolonged use of Methylergometrine with other ergot alkaloids can lead to ergotism, characterized by peripheral vasospasm and ischemia.
• It may interact with potent CYP3A4 inhibitors, such as ketoconazole, which can increase the concentration of Methylergometrine and enhance its effects.
• Use with vasoconstrictors may exacerbate vasoconstriction and increase the risk of hypertension and peripheral ischemia.
• Methylergometrine can decrease the effects of vasodilators, and concurrent use may require adjustment of vasodilator dosage.
• Antihypertensive medications may have reduced efficacy when used with Methylergometrine due to its hypertensive effects.
• The effectiveness of Methylergometrine may be decreased when used with bromocriptine, a dopamine agonist.
• It may interact with certain antibiotics, such as erythromycin, potentially leading to increased side effects.

Following are the food interactions for Methylergometrine Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can interfere with the metabolism of Methylergometrine, potentially leading to increased drug levels in the blood and an elevated risk of side effects.
• Alcohol intake is not recommended with Methylergometrine as it may enhance the risk of adverse effects, particularly those related to the central nervous system, such as dizziness and lightheadedness.
• Caffeine-rich foods and beverages, like coffee, tea, and energy drinks, should be consumed in moderation as they may counteract the effects of Methylergometrine by stimulating the blood vessels and heart.
• High-fat meals can potentially delay the absorption of Methylergometrine, affecting its onset of action. It is advisable to take the medication on an empty stomach or with a light meal.
• Salt and sodium-rich foods should be consumed in moderation as Methylergometrine can increase blood pressure, and a high-sodium diet may exacerbate this effect.
• Avoid consuming large amounts of potassium-rich foods like bananas, oranges, and spinach, as Methylergometrine can affect potassium levels, and excessive intake may lead to imbalances.
• Methylergometrine may interact with certain herbs and supplements, so it's important to inform your healthcare provider about any herbal remedies or supplements you are taking.
• Always follow the dietary advice provided by your healthcare professional, especially if you have specific dietary restrictions or medical conditions that require a tailored diet plan.

Methylergometrine Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The tablets should be kept in their original packaging, tightly sealed, to maintain their integrity and effectiveness. It is crucial not to expose the medication to extreme temperatures, so avoid storing it in hot areas like near a stove or inside a car during hot weather. Always check the expiration date, and if the tablets have passed their expiry, do not use them and dispose of them safely. Proper disposal is essential; do not throw the medication into the trash or flush it down the toilet. Consult a pharmacist or local waste management authority for guidance on safe disposal methods to protect the environment. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Methylergometrine Tablet:

• Take the tablet as directed by your doctor, usually within 5 minutes of delivery or as soon as possible after childbirth.
• Swallow the tablet whole with a glass of water, do not crush or chew.
• It is typically given as a single dose, and additional doses are not usually required.
• Methylergometrine is best taken on an empty stomach, at least 30 minutes before or 2 hours after meals.
• If you experience nausea or vomiting after taking the tablet, lie down until the symptoms pass.
• Inform your doctor if you have any allergies or medical conditions before taking this medication.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.