Metomide (5mg/5ml) 50ml Syrup

Metoclopramide is a dopamine D2 receptor antagonist in the central nervous system and an antagonist of the 5-HT3 receptor in the gastrointestinal tract. This action increases gastric motility and accelerates gastric emptying. It also has antiemetic properties by acting on the chemoreceptor trigger zone.

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Antiemetic/Prokinetic agent

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Syrup/Suspension

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Prophylaxis of chemotherapy-induced nausea and vomiting, Nausea and vomiting associated with cancer chemotherapy or radiotherapy, Diabetic gastric stasis, Gastro-oesophageal reflux disease, Diabetic gastric stasis, Prophylaxis of postoperative nausea and vomiting

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Metomide dosage for the indication of nausea and vomiting, duration as needed:

• Adults - 10-15 ml 30 minutes before meals, up to 4 times a day.
• Children (1-14 years) - 5-10 ml 30 minutes before meals, up to 3 times a day.

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Overdose can cause severe neurological symptoms. Seek medical help immediately.

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If you miss a dose, consume as soon as you remember. If it is close to the next feeding, skip the missed dose. Do not double up on doses.

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Taken orally, typically before meals and at bedtime. Follow the prescribed dosage and schedule.

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Metoclopramide should not be used if:

• Hypersensitivity
• Gastrointestinal hemorrhage
• Pheochromocytoma

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Extrapyramidal symptoms (usually acute dystonic reactions); parkinsonism; tardive dyskinesia; restlessness, drowsiness, dizziness, anxiety, confusion, tremor? hallucinations (rare); depression w/ suicidal ideation; hypotension, HTN, GI disturbances, dyspnoea, visual disturbances, urinary frequency and incontinence, headache; hypersensitivity reactions (rash, bronchospasm, angioedema); galactorrhoea or related disorders; blood disorders; transient increase in plasma-aldosterone concentration. IV: Cardiac conduction disorders, transient flushing of face and upper body (high dose).

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Patients with underlying neurological conditions, cardiac conduction disturbances, uncorrected electrolyte imbalance, bradycardia. Renal and hepatic impairment. Elderly, childn. Pregnancy and lactation.

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The drug interactions with metoclopramide include:

• CNS Depressants (e.g., alcohol) – Can enhance CNS depressant effects.
• Anticholinergic Drugs – May reduce metoclopramide effectiveness.

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The food interactions that should be considered while using metoclopramide are:

• Avoid alcohol as it may increase drowsiness and dizziness.
• Take 30 minutes before meals to enhance its effect on gastric motility.

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Metoclopramide should be stored at room temperature, away from light and moisture. Keep it in its original container and out of reach of children. Dispose of expired or unused Metoclopramide. Store this medication in a cool, dry place, away from direct sunlight and moisture, at room temperature (15-25°C). Keep it in its original container and out of reach of children and pets. Avoid storing it in bathrooms or areas prone to humidity. Properly dispose of any unused or expired medication according to local regulations or through a pharmacy take-back program to ensure safe disposal. Avoid flushing it down the toilet or pouring it into drains unless instructed to do so.

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