METRORUBORIL CREAM 30ML

Azelaic acid cream primarily exerts its therapeutic effects through multiple mechanisms of action. One of its key actions is inhibiting the activity of tyrosinase, an enzyme crucial for melanin production, thereby reducing hyperpigmentation. It also demonstrates anti-inflammatory properties by suppressing the production of pro-inflammatory cytokines and inhibiting the activation of certain immune cells, such as neutrophils and monocytes. Moreover, azelaic acid inhibits the growth of bacterial species like Propionibacterium acnes and Staphylococcus epidermidis, which are implicated in various skin conditions, by disrupting their cellular metabolism. This multifaceted mechanism of action makes azelaic acid effective in treating various dermatological issues, including acne, rosacea, and hyperpigmentation disorders.

Azelaic Acid

Azelaic Acid Cream is a dicarboxylic acid.

Cream

The following are the uses of Azelaic Acid Cream:

• Used for treating mild to moderate acne, reducing the number of blemishes and blackheads.
• Used for fading post-acne marks and dark spots, evening out skin tone.
• Used for managing rosacea symptoms like redness, bumps, and visible blood vessels.
• Used for its anti-inflammatory properties to calm irritated skin.
• Used for exfoliating the skin's surface to reveal brighter skin.
• Used for its antioxidant properties to protect the skin from free radical damage.
• Used for improving skin texture and promoting a clearer complexion.

To be used as per doctor's instructions

In the case of an overdose of Azelaic Acid Cream, it is important to remain calm and take appropriate action. First, discontinue use and thoroughly wash the affected area with mild soap and water. Avoid applying excessive amounts of water or irritating substances to the skin. Contact a healthcare professional or a poison control center for further guidance and to determine the necessary steps to address the overdose.

In the case of a missed dose of Azelaic Acid Cream, it is important to apply the medication as soon as you remember. If it is almost time for your next scheduled application, skip the missed dose and continue with your regular schedule. Do not apply extra cream to make up for the missed dose. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or provide specific instructions to ensure the treatment's effectiveness.

To apply Azelaic Acid Cream, wash and dry the affected area, then gently massage a thin layer of the cream onto the skin, ensuring complete coverage, typically twice a day or as directed by your healthcare provider.

Following are the conditions or circumstances when Azelaic Acid Cream should be avoided:

• Do not use if you have a known allergy or sensitivity to azelaic acid or any other ingredients in the cream.
• Avoid using this cream if you have severely broken or damaged skin, such as deep wounds or open sores.
• Not suitable for individuals with rosacea who are also experiencing swelling, blisters, or redness on the face.
• Discontinue use if you experience severe irritation, burning, or stinging at the application site.
• Do not use on skin affected by eczema or severe dryness.
• Avoid applying to skin affected by sunburn or severe sun damage.
• Not recommended for individuals with a history of skin conditions like psoriasis or severe acne.

The side effects of Azelaic Acid Cream may include:

• Skin irritation or redness at the application site
• Burning or stinging sensation
• Dryness or tightness of the skin
• Itching or tingling
• Peeling or flaking skin
• Swelling or inflammation
• Acne or skin breakouts (in rare cases)
• Temporary lightening or darkening of the skin

Following are the precautions and warnings for Azelaic Acid Cream:

• Avoid contact with eyes, nose, and mouth. In case of accidental contact, rinse thoroughly with water.
• Do not apply on broken or irritated skin. Seek medical attention if irritation persists.
• This medication is for external use only. Do not ingest or insert into body cavities.
• Azelaic Acid may cause skin irritation in some individuals. Perform a patch test on a small area of skin before regular use.
• Discontinue use if you experience severe redness, itching, or burning and consult a healthcare professional.
• Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as they may recommend alternative treatments.
• Avoid using other topical medications or treatments without medical advice to prevent potential interactions.

Following are the drug interactions for Azelaic Acid Cream:

• No significant drug interactions have been reported with Azelaic Acid Cream when used topically.
• However, it may interact with other topical medications, especially those containing benzoyl peroxide, which can cause skin dryness and irritation.
• Azelaic Acid can reduce the effectiveness of dapsone, a medication used to treat acne, when applied simultaneously.
• It is recommended to avoid using other topical acne treatments, such as retinoids or benzoyl peroxide, at the same time as Azelaic Acid Cream to prevent excessive skin irritation.
• The absorption of Azelaic Acid through the skin is minimal, so it is less likely to interact with oral medications.
• Nonetheless, it may be prudent to avoid using Azelaic Acid Cream with other topical agents containing the same active ingredient to prevent over-application and potential side effects.
• Always consult your healthcare provider or pharmacist for specific drug interaction concerns based on your medical history and current medications.

Following are the food interactions to be aware of when using Azelaic Acid Cream:

• Azelaic Acid Cream may cause a temporary increase in skin sensitivity, so it's advisable to avoid spicy foods that can lead to skin flushing or irritation.
• Citrus fruits and juices, like oranges or lemons, might cause a stinging sensation on the skin, so it's best to avoid them or consume them in moderation.
• Avoid excessive consumption of caffeine-rich foods and beverages as they might exacerbate skin redness and sensitivity.
• Dairy products, especially those high in lactose, could potentially influence the skin's pH and affect the effectiveness of the cream.
• While not a direct food interaction, ensure you wash your hands thoroughly after applying the cream to avoid transferring it to your eyes, nose, or mouth, which can cause irritation.
• There is no specific dietary restriction with Azelaic Acid Cream, but maintaining a balanced diet can generally support skin health.
• Always consult your healthcare provider for personalized advice, especially if you have specific dietary concerns or medical conditions.

Azelaic Acid Cream should be stored in a cool and dry place, preferably at room temperature, ensuring it is protected from direct sunlight and moisture. Keep the cream in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid extreme temperatures by not storing it in hot areas like near stoves or inside the bathroom, as this can impact the cream's effectiveness. Dispose of any expired or unused cream responsibly; do not flush it down the toilet or pour it into drainage systems. Consult your pharmacist for guidance on proper disposal methods. Always keep medications secure and out of children's reach to prevent accidental exposure.

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Following are the quick tips for Azelaic Acid Cream:

• Wash your hands before and after applying the cream to maintain hygiene.
• Clean and dry the affected area before applying the cream.
• Use a thin layer and gently rub the cream into the skin, ensuring complete coverage.
• Avoid applying the cream to broken or irritated skin, and do not use it on open wounds.
• Do not use more cream than prescribed, and do not cover the treated area with bandages.
• Avoid getting the cream in your eyes, nose, or mouth, and rinse thoroughly with water if contact occurs.
• Regular use as directed is important for achieving the best results.