Mezrel XR (30mg) 14 Capsules

Cyclobenzaprine's primary mechanism of action is as a central nervous system depressant, specifically targeting the spinal cord and brainstem. It is a 5-HT2 receptor antagonist, meaning it blocks the action of serotonin at these receptors. By inhibiting serotonin at the 5-HT2 receptors, cyclobenzaprine reduces muscle spasticity and alleviates pain. This action helps to relax the muscles and decrease muscle tone, making it effective in managing muscle spasms and associated discomfort. The drug's muscle relaxant properties are believed to be responsible for its therapeutic effects, particularly in conditions characterized by muscle hyperactivity and pain.

Cyclobenzaprine

Muscle relaxant.

Capsule

The following are the uses of Cyclobenzaprine Capsule:

• Used for muscle relaxation to relieve pain and discomfort associated with muscle spasms.
• Used for treating acute muscle injuries and strains.
• Used for managing chronic muscle pain in conditions like fibromyalgia.
• Used for reducing muscle stiffness and improving mobility.
• Used for providing short-term relief from muscle spasms caused by certain medical conditions.
• Used for aiding in physical therapy and rehabilitation programs.
• Used for promoting better sleep in individuals with muscle-related pain.
• Used for helping alleviate headache symptoms associated with muscle tension.

In the case of an overdose of Cyclobenzaprine Capsules, it is important to recognize the potential severity of the situation. Symptoms may include extreme drowsiness, confusion, blurred vision, and even difficulty breathing. Promptly seek medical assistance and inform healthcare professionals about the suspected overdose. They will provide guidance and necessary treatment to address the overdose, ensuring the best possible outcome. It is crucial to act quickly and not delay seeking help.

In the case of a missed dose of Cyclobenzaprine Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for advice on how to safely resume your medication regimen. It is recommended to set reminders or use a pill organizer to help you remember to take your medication as prescribed.

To take Cyclobenzaprine capsules, swallow the capsule whole with a full glass of water, as directed by your healthcare professional, and do not crush, chew, or open the capsule, as it is designed to be taken orally in its original form.

Following are the conditions/situations when Cyclobenzaprine Capsule should not be taken:

• Should not be used in individuals with a known allergy to Cyclobenzaprine or related medications.
• Contraindicated in patients with narrow-angle glaucoma.
• Not suitable for individuals with a history of heart attack or heart rhythm problems.
• Should not be used if you have a recent history of heart surgery or uncontrolled high blood pressure.
• Contraindicated in patients with urinary retention or difficulty urinating.
• Avoid using this medication if you have a blockage in your stomach or intestines.
• Not recommended for individuals with liver or kidney disease.
• Do not take this medication if you have an overactive thyroid (hyperthyroidism).
• Should not be used in patients with a history of seizures or epilepsy.
• Contraindicated during pregnancy and breastfeeding.

The side effects of Cyclobenzaprine Capsule may include:

• Drowsiness
• Dry mouth
• Fatigue and general weakness
• Dizziness
• Blurred vision
• Constipation
• Difficulty urinating

Following are the precautions and warnings for Cyclobenzaprine Capsule:

• Do not use if you are allergic to Cyclobenzaprine or any ingredients in the capsule.
• This medication may cause drowsiness and dizziness, so avoid driving or operating heavy machinery until you know how it affects you.
• Alcohol and other central nervous system depressants should be used with caution as they may enhance the sedative effects of Cyclobenzaprine.
• Patients with a history of liver or kidney disease should use it with caution, as it is primarily metabolized in the liver and excreted by the kidneys.
• Elderly patients may be more sensitive to the effects of Cyclobenzaprine, so lower doses are recommended.
• It should be used with caution in patients with a history of urinary retention or glaucoma.
• If you have a heart condition or high blood pressure, consult your doctor before taking this medication.

Following are the drug interactions for Cyclobenzaprine Capsule:

• Monoamine oxidase inhibitors (MAOIs) • Concomitant use can lead to serious adverse reactions, including serotonin syndrome.
• Central nervous system depressants (e.g., alcohol, benzodiazepines) • Enhanced sedative effects and impaired cognitive function may occur.
• Serotonergic drugs (e.g., SSRIs, SNRIs, triptans) • Risk of serotonin syndrome is increased.
• Anticoagulants (e.g., warfarin) • May potentiate the anticoagulant effect, requiring close monitoring.
• Drugs metabolized by CYP450 enzymes • Cyclobenzaprine may inhibit CYP1A2, CYP2D6, and CYP3A4, altering the metabolism of certain medications.
• Anticonvulsants and antipsychotics • Blood levels of these drugs may be affected, leading to potential side effects.
• Tramadol and other opioid analgesics • Risk of respiratory depression and sedation is increased.
• Medications affecting liver enzymes • May alter Cyclobenzaprine metabolism.

Following are the food interactions for Cyclobenzaprine Capsule:

• Avoid grapefruit and grapefruit juice as they can increase the concentration of Cyclobenzaprine in the blood, leading to potential side effects.
• Alcohol consumption should be limited or avoided as it can enhance the sedative effects of Cyclobenzaprine, causing increased drowsiness and impaired coordination.
• Avoid caffeine-rich beverages like coffee, tea, or energy drinks as they can counteract the relaxing effect of Cyclobenzaprine and may lead to anxiety or restlessness.
• Consuming fatty foods may slightly delay the absorption of Cyclobenzaprine but does not significantly impact its effectiveness.
• Avoid herbal supplements like St. John's Wort as it can interfere with the metabolism of Cyclobenzaprine, potentially affecting its efficacy.
• Do not consume large meals immediately after taking the capsule, as it may slow down the absorption process.
• Always take the medication with a full glass of water to ensure proper swallowing and absorption.
• Consult your healthcare provider for personalized advice on diet and medication interactions.

Cyclobenzaprine Capsules should be stored in a secure and dry location, preferably at room temperature, ensuring protection from direct sunlight, moisture, and heat. It is crucial to keep the capsules in their original container, tightly sealed, to maintain their integrity and prevent contamination. Always verify the expiration date before use, and dispose of any unused or expired capsules responsibly. Do not flush or pour them down the drain; instead, consult a pharmacist or healthcare professional for appropriate disposal methods. Keep the medication out of children's reach to prevent accidental consumption, as it can be harmful if ingested without proper medical supervision. Proper storage and disposal practices are essential for maintaining the safety and efficacy of Cyclobenzaprine Capsules.

Following are the quick tips for Cyclobenzaprine Capsule:

• Swallow the capsule whole; do not crush, chew, or open it.
• Take it with or without food as directed by your doctor.
• Ensure you are not allergic to any ingredients before taking it.
• Avoid alcohol while using this medication to prevent increased side effects.
• Do not drive or operate machinery until you know how this medicine affects you.
• Inform your doctor if you have liver or kidney problems.
• Store the capsules at room temperature, away from moisture and light.