MIACALCIC INJ

Calcitonin, when administered as an injection, primarily acts by directly inhibiting osteoclast-mediated bone resorption. It binds to specific calcitonin receptors on osteoclasts, leading to a decrease in their activity and bone breakdown. This mechanism is triggered by the activation of intracellular signaling pathways, which ultimately result in a reduction of calcium release from bones into the bloodstream. The binding of calcitonin to its receptors also stimulates the inhibition of osteoclast formation and promotes osteoclast apoptosis, further contributing to the suppression of bone resorption. This targeted action makes calcitonin injection an effective therapeutic agent for managing certain bone-related conditions.

Calcitonin

Calcitonin, Antiresorptive.

Injection

The following are the uses of Calcitonin Injection:

• Used for treating Paget's disease, a bone disorder, by slowing down the breakdown and rebuilding of bones.
• Used for managing bone pain and reducing the risk of fractures in patients with Paget's disease.
• Used for preventing bone loss and maintaining bone density in certain conditions like osteoporosis.
• Used for treating hypercalcemia, a condition of high calcium levels in the blood, by reducing calcium release from bones.
• Used for managing calcium levels in patients with certain types of cancer that affect bone metabolism.
• Used for providing targeted bone pain relief in various bone-related conditions.
• Used for supporting overall bone health and reducing bone-related complications in specific medical scenarios.

In the case of an overdose of Calcitonin Injection, prompt medical intervention is necessary. Signs of overdose may include severe nausea, vomiting, and diarrhea, as well as unusual weakness and fatigue. If an overdose is suspected, seek medical help immediately. Treatment involves supportive care, monitoring vital signs, and managing symptoms until the drug's effects wear off. It is crucial to act swiftly and inform healthcare professionals about the suspected overdose.

In the case of a missed dose of Calcitonin Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss several doses, contact your healthcare professional for advice on how to safely resume your medication and adjust your dosing schedule. It is crucial to maintain a consistent treatment routine for optimal results.

To administer the Calcitonin Injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, inject the prescribed dose slowly, and then withdraw the needle while applying pressure with a sterile cotton ball if needed to stop any bleeding.

Here are the conditions or situations when Calcitonin Injection should not be administered:

• Allergy Should not be used if the patient has a known allergy to Calcitonin or any of its excipients.
• Pregnancy Contraindicated in pregnant women as it may affect fetal development.
• Hypersensitivity Not recommended for patients with a history of hypersensitivity reactions to Calcitonin or similar medications.
• Bone Disorders Should be avoided in individuals with severe osteoporosis or Paget's disease of the bone.
• Renal Impairment Not suitable for patients with severe kidney problems or end-stage renal disease.
• Thyroid Disorders Should not be used in patients with untreated hyperthyroidism or uncontrolled hypothyroidism.
• Recent Radiation Therapy Contraindicated in patients who have recently undergone radiation treatment for bone-related conditions.
• Severe Heart Disease Not recommended for individuals with unstable or severe heart conditions.
• Children Calcitonin Injection is not indicated for use in pediatric patients.
• Breastfeeding It may pass into breast milk, so it is usually not recommended for breastfeeding mothers.
• Ocular Surgery Should be used with caution in patients who have recently undergone eye surgery.

The side effects of Calcitonin Injection may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain or cramps
• Allergic reactions (such as skin rash, itching, hives)
• Fatigue and dizziness
• Redness, swelling, or pain at the injection site
• Joint and muscle pain
• Headache

Following are the precautions and warnings for Calcitonin Injection:

• This medication is intended for injection and should only be administered by a healthcare professional. Do not attempt to self-inject.
• Allergic reactions are possible; inform your doctor if you have any known allergies, especially to fish, as some calcitonin products may contain fish proteins.
• Calcitonin injection may cause nausea and vomiting. Inform your doctor if these symptoms persist or worsen.
• It may lead to decreased bone mineral density and an increased risk of fractures. Long-term monitoring of bone density is recommended.
• Patients with kidney stones or a history of kidney disease should be monitored closely, as calcitonin can affect kidney function.
• Not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks. Consult your doctor for advice.
• If you experience any chest pain, irregular heartbeat, or signs of low blood pressure, seek immediate medical attention.

Following are the drug interactions for Calcitonin Injection:

• Concurrent use with bisphosphonates may lead to increased bone pain and decreased efficacy of both drugs.
• Concomitant use with lithium can result in increased calcitonin levels and reduced lithium clearance.
• Calcitonin may enhance the effect of calcium channel blockers, leading to increased hypotensive effects.
• The effectiveness of calcitonin may be reduced when used with thiazide diuretics, which can increase calcium excretion.
• Caution is advised when using calcitonin with other medications that affect bone metabolism, such as vitamin D analogs, as it may alter the desired therapeutic response.
• It may interact with antineoplastic agents, potentially affecting bone turnover and calcium homeostasis.
• Calcitonin can increase the risk of hypocalcemia when used with other drugs that lower calcium levels, such as certain anticonvulsants.

Following are the food interactions for Calcitonin Injection:

• Avoid excessive intake of calcium-rich foods like dairy products, leafy greens, and calcium-fortified foods during treatment. High calcium levels can reduce the effectiveness of Calcitonin.
• Maintain a balanced diet with moderate calcium intake, as directed by your healthcare provider.
• Avoid consuming large amounts of vitamin D supplements or foods rich in vitamin D, such as fatty fish and egg yolks, as they can increase calcium absorption.
• Limit the consumption of calcium-rich antacids, as they may interfere with the action of Calcitonin.
• Stay well-hydrated, as dehydration can affect bone health and potentially impact the effectiveness of the medication.
• Avoid excessive alcohol consumption, as it may affect bone metabolism and potentially interact with the medication's effects.
• Consult your doctor or dietician for a personalized diet plan to support your bone health during Calcitonin therapy.

Calcitonin Injection should be stored and disposed of with utmost care. Store it in a refrigerator, between 2°C and 8°C (36°F and 46°F), in its original packaging to protect it from light. Do not freeze the medication as it may affect its potency. Ensure the injection is kept away from children and pets to prevent accidental exposure. If the injection is no longer needed or has passed its expiration date, do not dispose of it by flushing or pouring it down the drain. Contact your healthcare provider or pharmacist for guidance on safe disposal methods to minimize environmental impact.

Following are the quick tips for Calcitonin Injection:

• Administer the injection as directed by your healthcare professional for effective pain relief.
• Ensure proper injection technique to prevent discomfort and maximize benefits.
• Rotate injection sites to minimize skin irritation and tissue damage.
• Dispose of used needles and syringes safely in designated sharps containers.
• Store the medication as directed on the package insert to maintain its potency.
• Inform your doctor if you have kidney or liver problems before using this medication.
• Report any side effects, especially persistent nausea or allergic reactions, to your healthcare provider promptly.