MIACALCIC N/SPRAY 200IU

Calcitonin, a hormone naturally produced in the human body, primarily targets osteoclasts, the cells responsible for breaking down bone tissue during bone remodeling. When administered as a nasal spray, synthetic calcitonin acts as an osteoclast inhibitor. It binds to specific calcitonin receptors on the osteoclasts, leading to a decrease in their activity and bone resorption. This mechanism helps slow down bone loss and promotes a more balanced bone remodeling process, making it useful in the treatment of certain bone-related conditions.

Calcitonin-Salmon

Nasal calcitonin.

Spray

The following are the uses of Calcitonin Spary:

• Used for treating osteoporosis in postmenopausal women, helping to reduce the risk of fractures.
• Used for managing bone pain and preventing bone loss in Paget's disease.
• Used for reducing bone resorption in patients with hypercalcemia, a condition of high calcium levels.
• Used for aiding in the prevention of bone loss in immobilized patients or those with reduced mobility.
• Used for treating bone loss in individuals with conditions like rheumatoid arthritis.
• Used for supporting bone health in patients recovering from bone fractures or surgeries.
• Used for managing bone metabolism in specific medical conditions as advised by healthcare professionals.

In the case of an overdose of Calcitonin Spray, it is important to remain calm and take appropriate actions. The first step is to discontinue the use of the spray and seek medical advice. Contact a healthcare professional or poison control center for guidance. They will provide specific instructions based on the severity of the overdose and individual health factors. It is crucial to follow their recommendations to ensure the best possible outcome.

In the case of a missed dose of Calcitonin Spray, it is important to administer the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss several doses, contact your healthcare provider for advice on how to get back on track with your treatment plan. It is recommended to keep a consistent schedule for optimal effectiveness.

To use Calcitonin Spray, gently blow your nose to clear the nostrils, then tilt your head forward slightly, insert the spray nozzle into one nostril, and administer the prescribed number of sprays while breathing in gently through the nose.

Here are the circumstances when Calcitonin Nasal Spray should not be used:

• Avoid using if you have a known allergy to Calcitonin or any of the spray's components.
• Not suitable for individuals with a history of medullary thyroid carcinoma or multiple endocrine neoplasia.
• Contraindicated in patients with hypocalcemia (low calcium levels in the blood).
• Do not use if you have untreated or uncontrolled hypothyroidism.
• Avoid using Calcitonin spray if you have had radiation therapy to your head, neck, or upper chest.
• Not recommended for individuals with recent or ongoing surgery or trauma affecting the head, neck, or spine.
• Should not be used in patients with a history of Paget's disease of bone.

The side effects of Calcitonin Spray may include:

• Nausea and vomiting
• Runny nose or nasal irritation
• Sore throat
• Headache
• Skin rash or itching
• Fatigue and increased tiredness
• Joint or muscle pain

Following are the precautions and warnings for Calcitonin Nasal Spray:

• Not recommended for individuals with a known hypersensitivity or allergy to Calcitonin or any of the spray's components.
• Should be used with caution in patients with a history of asthma or other respiratory diseases, as it may cause bronchospasm.
• Patients with kidney stones or a history of kidney problems should use it under medical supervision, as it can affect kidney function.
• Avoid spraying into the eyes or on the skin; if accidental contact occurs, rinse thoroughly with water.
• Not suitable for individuals with untreated low blood calcium levels (hypocalcemia).
• Discontinue use and seek medical attention if symptoms of an allergic reaction, such as difficulty breathing or swelling of the face, occur.
• Consult a healthcare professional before using Calcitonin Spray if you are pregnant, planning to become pregnant, or breastfeeding.

Following are the drug interactions for Calcitonin Spray:

• Thiazide diuretics, such as hydrochlorothiazide, may reduce the effectiveness of Calcitonin Spray as they can increase calcium excretion.
• Bisphosphonates, like alendronate, can have additive effects on bone metabolism, potentially increasing the risk of hypocalcemia.
• Calcitonin Spray may reduce the absorption of calcium supplements, so monitoring of calcium levels is advised.
• Anticonvulsants like phenytoin can decrease the effectiveness of Calcitonin Spray by increasing bone resorption.
• Estrogen-containing medications may reduce the effectiveness of Calcitonin Spray as they can increase bone density.
• The effects of other osteoporosis medications, such as teriparatide, may be altered when used with Calcitonin Spray, requiring close monitoring.
• Some antibiotics, such as tetracyclines, can form complexes with Calcitonin Spray, reducing its effectiveness.

Following are the food interactions for Calcitonin Spray:

• Avoid consuming dairy products like milk, cheese, or yogurt immediately after using the spray, as calcium-rich foods can interfere with the absorption of Calcitonin.
• Avoid consuming calcium supplements or calcium-fortified foods close to the time of medication administration.
• Wait at least 30 minutes after using the spray before eating or drinking anything to ensure optimal absorption.
• Grapefruit and grapefruit juice should be consumed cautiously as they may alter the effectiveness of Calcitonin, potentially leading to reduced bone density.
• Alcohol intake is generally not recommended for individuals with osteoporosis as it can negatively impact bone health, but it does not directly interact with Calcitonin.
• Avoid excessive caffeine consumption as it may interfere with the body's calcium balance and potentially reduce the effectiveness of Calcitonin.
• A balanced diet rich in essential nutrients, especially vitamin D and calcium, is crucial for supporting bone health while using Calcitonin.
• Always consult your healthcare provider for personalized dietary advice and medication instructions.

Calcitonin Spray storage and disposal guidelines should be carefully followed to ensure safety and maintain the integrity of the medication. Store the spray at room temperature, preferably between 68°F and 77°F (20°C and 25°C), in a dry place away from heat, moisture, and direct sunlight. Keep the medication in its original packaging and ensure the cap is tightly secured to prevent leakage and contamination. Regularly check the expiration date, and do not use the spray if it has expired. For disposal, do not pour the medication down the sink or flush it down the toilet. Instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for appropriate methods to safely dispose of the spray, ensuring it is kept out of the reach of children and pets.

Following are the quick tips for Calcitonin Spray:

• Ensure you receive proper training on how to use the nasal spray device.
• Administer the prescribed dose into one nostril, alternating nostrils with each use.
• Aim the spray away from the nasal septum (the center of the nose) to avoid discomfort.
• Gently blow your nose before using the spray to clear any blockages.
• Avoid sneezing immediately after administering the spray for better absorption.
• Store the spray at room temperature, away from moisture and sunlight.
• Regularly clean the spray nozzle with a damp cloth to maintain hygiene.