Micronase (5mg) 100 Tablets

Glyburide 5mg tablets primarily work by stimulating the release of insulin from the pancreatic beta cells, specifically targeting ATP-sensitive potassium channels in these cells. By binding to these channels, glyburide promotes their closure, leading to depolarization of the cell membrane and subsequent calcium influx. This increase in intracellular calcium triggers insulin secretion, which helps lower blood glucose levels. The selective action on the pancreatic beta cells makes glyburide effective in managing type 2 diabetes, as it enhances the body's natural ability to regulate glucose by increasing insulin production in response to elevated blood sugar.

Glyburide 5mg

Sulfonylurea.

Tablet

The following are the uses of Glyburide 5mg Tablet:

• Used for controlling blood sugar levels in type 2 diabetes mellitus.
• Used to improve insulin sensitivity and reduce insulin resistance.
• Used to manage hyperglycemia and stabilize glucose metabolism.
• Used for long-term blood sugar control, preventing diabetic complications.
• Used to lower the risk of diabetes-related heart and blood vessel problems.
• Used to regulate glucose levels, aiding in overall diabetes management.
• Used for blood sugar regulation, preventing diabetic emergencies.

In the case of an overdose of Glyburide 5mg Tablets, prompt medical attention is necessary. Symptoms of an overdose may include severe hypoglycemia, characterized by dizziness, sweating, confusion, and in severe cases, loss of consciousness. It is crucial to contact a healthcare professional or emergency services immediately if an overdose is suspected. They will provide the necessary guidance and treatment to manage the overdose and prevent potential complications. Time is of the essence in such situations.

In the case of a missed dose of Glyburide 5mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to adjust your dose or provide specific instructions to ensure you maintain the proper blood sugar control.

To take Glyburide 5mg Tablet, swallow the tablet whole with a full glass of water, preferably with your first meal of the day, or as directed by your healthcare professional, ensuring you follow the prescribed dosage and schedule provided by your doctor.

Following are the conditions when Glyburide 5mg Tablet should not be used:

• Should not be taken by individuals with a known allergy to Sulfonylureas or any of its ingredients.
• Contraindicated in patients with type 1 diabetes mellitus.
• Not suitable for individuals with diabetic ketoacidosis.
• Should not be used in patients with severe liver or kidney disease.
• Contraindicated during pregnancy and breastfeeding.
• Not recommended for individuals with certain enzyme deficiencies (glucose-6-phosphate dehydrogenase deficiency).
• Avoid in patients with major surgeries or severe infections, as it may affect blood sugar control.
• Should not be used in individuals with a known sensitivity to Sulfonamides, as Glyburide is a Sulfonamide derivative.
• Not suitable for patients with porphyria, a rare metabolic disorder.

The side effects of Glyburide 5mg Tablet may include:

• Hypoglycemia (low blood sugar)
• Nausea and vomiting
• Stomach pain or discomfort
• Diarrhea or constipation
• Headache
• Dizziness or lightheadedness
• Skin rash or itching
• Weight gain

Following are the precautions and warnings for Glyburide 5mg Tablet:

• Not recommended for patients with a known allergy to Glyburide or other sulfonylurea drugs.
• Regular monitoring of blood glucose levels is essential, and adjustments may be needed during stress, infection, or injury.
• Patients with kidney or liver disease should use with caution as it may require dosage adjustments.
• Alcohol consumption should be avoided or limited as it can affect blood sugar control.
• May cause hypoglycemia, especially in elderly, malnourished, or debilitated patients, and those with adrenal or pituitary insufficiency.
• Should be used with caution in individuals with G6PD deficiency due to the risk of hemolytic anemia.
• Pregnant and breastfeeding women should consult their doctor before taking this medication as it may not be suitable.
• Patients should be aware of the symptoms of hypoglycemia and hyperglycemia and know how to manage them.

Following are the drug interactions for Glyburide 5mg Tablet:

• Alcohol may cause additive effects, leading to hypoglycemia. Avoid or limit alcohol consumption.
• When used with other antidiabetic medications, such as insulin or metformin, close monitoring of blood glucose levels is required to prevent severe hypoglycemia.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids can reduce the effectiveness of Glyburide, requiring dosage adjustments.
• Beta-blockers, clonidine, and certain calcium channel blockers may mask the symptoms of hypoglycemia, making it harder to detect.
• Rifampin, a CYP3A4 inducer, can decrease the efficacy of Glyburide by increasing its metabolism.
• Fluconazole, a CYP2C9 inhibitor, can increase Glyburide levels, leading to prolonged hypoglycemia.
• Probenecid may increase the concentration of Glyburide by inhibiting renal excretion, potentially enhancing its effects.

Following are the food interactions for Glyburide 5mg Tablet:

• Alcohol consumption should be limited as it can increase the risk of low blood sugar (hypoglycemia) and may interfere with the medication's effectiveness.
• Grapefruit and grapefruit juice should be avoided as they can increase the blood levels of Glyburide, potentially leading to a higher risk of side effects.
• Avoid excessive consumption of sugar and sugary foods as they can counteract the blood sugar-lowering effect of the medication.
• Consume a consistent and balanced diet to ensure stable blood sugar levels, including complex carbohydrates, fiber, lean proteins, and healthy fats.
• Avoid fasting or skipping meals to prevent hypoglycemic episodes, especially if you have a history of diabetes.
• Be cautious with high-fiber diets as they may affect the absorption of Glyburide; consult your healthcare provider for guidance.
• Some herbal supplements like garlic, ginseng, and bitter melon may interact with Glyburide, so inform your doctor about any herbal remedies you are taking.
• Always follow the dietary recommendations provided by your healthcare professional to ensure optimal management of your blood sugar levels while taking Glyburide.

Glyburide 5mg Tablets should be stored in a cool, dry area, ideally at room temperature between 68°F and 77°F (20°C and 25°C). Protect the tablets from excessive heat, moisture, and direct sunlight, and ensure they are kept in their original container with the lid tightly sealed. It is crucial not to store the medication in the bathroom or near the kitchen sink, as humidity can affect its quality. When disposing of unused or expired tablets, do not throw them into the trash or flush them down the toilet. Instead, consult your pharmacist or local waste disposal company for specific instructions on safe disposal methods, ensuring that the medication is kept away from children and pets at all times.

Following are the quick tips for Glyburide 5mg Tablet:

• Consult your doctor for the right dosage and duration of this medication.
• Take the tablet with or after a meal to minimize stomach-related side effects.
• Do not crush or chew the tablet; swallow it whole with a glass of water.
• Maintain a consistent schedule for taking the medication to ensure stable blood sugar levels.
• Regularly monitor your blood sugar levels as advised by your doctor.
• Inform your doctor if you have kidney or liver problems before taking this medicine.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.